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ACAA2

  • Official Full Name

    acetyl-CoA acyltransferase 2

  • Overview

    The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal.
  • Synonyms

    ACAA2; acetyl-CoA acyltransferase 2; acetyl Coenzyme A acyltransferase 2; 3-ketoacyl-CoA thiolase, mitochondrial; DSAEC; mitochondrial 3 oxoacyl Coenzyme A thiolase; T1; beta ketothiolase; beta-ketothiolase; acetyl-Coenzyme A acyltransferase 2; mitochondr;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACAA2-719H Recombinant Human ACAA2 Mammalian Cell His
Human ACAA2-9261H Recombinant Human ACAA2, GST-tagged E.coli GST C-term-300a.a.
Human ACAA2-124H Recombinant Human ACAA2 Protein, GST-Tagged Wheat Germ GST
Human ACAA2-3044H Recombinant Human ACAA2, His-tagged E.coli His 397
Human ACAA2-7576H Recombinant Human ACAA2, His-tagged E.coli His 17-397aa
Human ACAA2-9118HCL Recombinant Human ACAA2 293 Cell Lysate HEK293 N/A
Human ACAA2-6378H Recombinant Human ACAA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACAA2-0176H Recombinant Human ACAA2 Protein (Arg90-Ala397), N-His-tagged E.coli N-His Arg90-Ala397
Human ACAA2-252H-B Recombinant Human ACAA2 Protein Pre-coupled Magnetic Beads HEK293
Human ACAA2-1316H Recombinant Human ACAA2 Protein (17-397 aa), His-tagged Yeast His 17-397 aa
Human ACAA2-872HF Recombinant Full Length Human ACAA2 Protein, GST-tagged In Vitro Cell Free System GST 397 amino acids
Human ACAA2-1365HFL Recombinant Full Length Human ACAA2 Protein, C-Flag-tagged Mammalian cells Flag
Human ACAA2-252H Recombinant Human ACAA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Acaa2-8155M Recombinant Mouse Acaa2 protein, His & T7-tagged E.coli His/T7 Arg90~Ala397 (Accession # Q8BWT1)
Mouse Acaa2-1484M Recombinant Mouse Acaa2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ACAA2-434R Recombinant Rat ACAA2 Protein Mammalian Cell His
Rat ACAA2-89R Recombinant Rat ACAA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ACAA2-89R-B Recombinant Rat ACAA2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ACAA2-196R Recombinant Rhesus monkey ACAA2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ACAA2-25R Recombinant Rhesus Macaque ACAA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ACAA2-25R-B Recombinant Rhesus Macaque ACAA2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ACAA2-12287Z Recombinant Zebrafish ACAA2 Mammalian Cell His
Chicken ACAA2-1708C Recombinant Chicken ACAA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACAA2 Related Articles

ACAA2 involved in several pathways and played different roles in them. We selected most pathways ACAA2 participated on our site, such as Biosynthesis of antibiotics, Fatty Acid Biosynthesis, Fatty acid degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biosynthesis of antibioticsLDHAL6B;AK7;GPR19;DAO;ECHS1;PAICS;DLD;ACAA2;DAO1
Fatty Acid BiosynthesisFASN;MCAT;ACACB;ACSL4B;ECHDC2;ACSBG2;ECHDC3;ACSL1B;ACSBG1
Fatty acid degradationACSL4;ECI2;ALDH7A1;CPT2;ACADL;ADH1A;CYP4A14;GCDHA;HADHAB
Fatty acid elongationACAA2;ELOVL1;HADHAA;ELOVL6;ELOVL2;ELOVL7;HADH;ELOVL7A;MECR
Fatty acid metabolismCPT2;OXSM;ELOVL6;ACAA1;ACSL4;ACSL1A;Scd1;ACADL;CPT1B
Metabolic pathwaysFTCD;ACY1;MTMR4;NAGS;MIBP;INPP5L;POLG2;ADSS;UGT8
Valine, leucine and isoleucine degradationHMGCLL1;IVD;ACAA1;ALDH9A1B;DLDH;MCCC1;HADHAA;HMGCS1;HSD17B10
bile acid biosynthesis, neutral pathwayPOR;ACAA2

ACAA2 has several biochemical functions, for example, acetyl-CoA C-acyltransferase activity, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAA2 itself. We selected most functions ACAA2 had, and list some proteins which have the same functions with ACAA2. You can find most of the proteins on our site.

Function Related Protein
acetyl-CoA C-acyltransferase activityACAA2;ACAA1;ACAA1A;HADHB
poly(A) RNA bindingMETAP2;MATR3;REXO4;MRTO4;MACF1;SLC25A11;EIF1B;MRPL41;LARP1
protein bindingSLAMF6;BBS7;DENR;FAM189B;PPP2R2A;DMKN;PRSS8;TRIM63;GOLGA2

ACAA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAA2.

LAMTOR5; fliG; ARMC6

Carrier, B; Wen, S; et al. Alpha-Lipoic Acid Reduces LDL-Particle Number and PCSK9 Concentrations in High-Fat Fed Obese Zucker Rats. PLOS ONE 9:-(2014).
Baghel, AS; Tandon, R; et al. Characterization of protein acyltransferase function of recombinant purified GlnA1 from Mycobacterium tuberculosis: A moon lighting property. MICROBIOLOGICAL RESEARCH 166:662-672(2011).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What is the molecular weight of ACAA2 protein? 12/20/2022

The molecular weight of ACAA2 protein is approximately 45 kDa.

How does ACAA2 contribute to the pathogenesis of certain types of cancer? 05/31/2022

ACAA2 expression is upregulated in some types of cancer, including prostate and ovarian cancer.

How is ACAA2 protein regulated at the transcriptional level? 12/24/2020

ACAA2 protein is regulated at the transcriptional level by multiple factors, including PPARs and SREBP-1c.

Where is ACAA2 predominantly expressed in the human body? 03/24/2020

ACAA2 is predominantly expressed in the liver and adipose tissue.

What is the clinical significance of ACAA2 protein in human diseases and disorders? 04/14/2019

ACAA2 may have clinical significance in the diagnosis and treatment of metabolic disorders and certain types of cancer.

What is the primary function of acetyl-CoA acyltransferase 2 (ACAA2) protein? 12/19/2018

ACAA2 protein's primary function is to participate in fatty acid and ketone body metabolism.

What is the role of ACAA2 in the development of metabolic diseases, such as obesity and diabetes? 08/29/2018

ACAA2 has been implicated in the development of metabolic disorders, including obesity and type 2 diabetes.

What are the known inhibitors or activators of ACAA2 protein? 08/03/2018

Some known inhibitors of ACAA2 include hexachlorophene and fusicoccin-A, while known activators include medium-chain fatty acids and certain drugs.

How does ACAA2 participate in the metabolism of fatty acids and ketone bodies? 02/06/2018

ACAA2 catalyzes the transfer of acyl groups between CoA and acyl-CoA substrates.

What is the three-dimensional structure of ACAA2 protein? 03/11/2015

The three-dimensional structure of ACAA2 protein is characterized by an alpha/beta hydrolase fold.

Customer Reviews (3)

Write a review
Reviews
02/22/2021

    Highly effective in detecting and measuring the activity of protein kinases in kinase assays.

    01/21/2021

      Provides consistent and accurate quantification of the target protein in different assay formats.

      04/05/2017

        Shows excellent performance in detecting and measuring the activity of proteases in protease assays.

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