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ACADM

  • Official Full Name

    acyl-CoA dehydrogenase, C-4 to C-12 straight chain

  • Overview

    This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ACADM; acyl-CoA dehydrogenase, C-4 to C-12 straight chain; acyl Coenzyme A dehydrogenase, C 4 to C 12 straight chain; medium-chain specific acyl-CoA dehydrogenase, mitochondrial; ACAD1; MCAD; MCADH; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chai;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACADM-26047TH Recombinant Human ACADM, His-tagged E.coli His 396 amino acids
Human ACADM-9268H Recombinant Human ACADM, His-tagged E.coli His 70-421a.a.
Human ACADM-133H Recombinant Human ACADM Protein, GST-Tagged Wheat Germ GST
Human ACADM-134H Recombinant Human ACADM Protein, GST-Tagged Wheat Germ GST
Human ACADM-9114HCL Recombinant Human ACADM 293 Cell Lysate HEK293 N/A
Human ACADM-0657H Recombinant Human ACADM Protein (Lys26-Asn421), N-His-tagged E.coli N-His Lys26-Asn421
Human ACADM-23H Recombinant Human ACADM Protein, His-tagged E.coli N-His Trp191-Asn421
Human ACADM-1433H Recombinant Human ACADM Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACADM-896HF Recombinant Full Length Human ACADM Protein, GST-tagged In Vitro Cell Free System GST 421 amino acids
Mouse Acadm-8157M Recombinant Mouse Acadm protein, His & T7-tagged E.coli His/T7 Met131~Asn421 (Accession # P45952)
Mouse ACADM-1163M Recombinant Mouse ACADM Protein Mammalian Cell His
Mouse Acadm-5595M Recombinant Mouse Acadm Protein (Lys26-Asn421), C-His tagged E.coli C-His Lys26-Asn421
Mouse ACADM-238M Recombinant Mouse ACADM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Acadm-503M Recombinant Mouse Acadm Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ACADM-238M-B Recombinant Mouse ACADM Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ACADM-12251Z Recombinant Zebrafish ACADM Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACADM Related Articles

ACADM involved in several pathways and played different roles in them. We selected most pathways ACADM participated on our site, such as Fatty acid degradation, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACADM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid degradationPECI;ECI2;HADH;ALDH2;GCDHA;GCDH;ACSL3;ACSL1A;ACSBG1
Valine, leucine and isoleucine degradationMCCC1;ALDH9A1B;AUH;BCAT2;MUT;OXCT2;AOX2P;HMGCS1;ACAT1
beta-Alanine metabolismSRM;ALDH3B1;ALDH2;ALDH9A1A.1;SMOX;ALDH7A1;AOC3;ALDH1A3;AOC2
Propanoate metabolismMUT;ACACB;BCKDHB;MLYCD;SUCLG1;ackA;ALDH6A1;SUCLA2;HADHAA
Metabolic pathwaysIDH1;LIPT1;CYP51A1;SPTLC2A;NANS;COQ7;PPAP2B;ACSL4B;PNPLA2
Carbon metabolismPRPS1L1;PGAM1B;MDH2;SDS;ACAT2;TPI1B;GLUD1B;OGDHA;ENO2
Fatty acid metabolismHSD17B12;ACSL5;ACACA;PECR;FADS2;Scd1;HADHB;EHHADH;MCAT
PPAR signaling pathwayRXRBA;PDPK1B;CYP4A12A;FABP7;FABP1;CYP4A10;MMP1;SCP2A;FABP2

ACADM has several biochemical functions, for example, acyl-CoA dehydrogenase activity, electron carrier activity, fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACADM itself. We selected most functions ACADM had, and list some proteins which have the same functions with ACADM. You can find most of the proteins on our site.

Function Related Protein
acyl-CoA dehydrogenase activityACADS;ACOXL;ACADM;ACAD8;ACADVL;ACOX2;ACAD9;ACADSB;ACOX3
electron carrier activityIVD;GLRX2;ACAD9;AKR1C4;ACOXL;ACADVL;ACADL;AKR7A3;ME2
fatty-acyl-CoA bindingGCDHA;ACADS;ACADSB;ACOX2;ACAD11;ACADVL;ACAD8;PECI;ACOX1
flavin adenine dinucleotide bindingFMO1;AOX1;FMO3;FOXRED2;SQLEA;MAOA;AOX4;CYB5R3;AOX3
identical protein bindingACY3;DYNLT1C;CIDEB;RAD51;TRIM21;ADIPOR1;ADIPOQ;NOXO1;GPR50
medium-chain-acyl-CoA dehydrogenase activityACAD11;ACADM;RSAD1
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptorGCDHA;ACADVL;GCDH;GCDHB;ACADL;ACOX1;ACAD9;ACOXL;ACAD11

ACADM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACADM here. Most of them are supplied by our site. Hope this information will be useful for your research of ACADM.

USP50; USP20; trmn6_yerpe; guaA; HDAC1; CLPP; GABARAPL1

Baik, M; Nguyen, TH; et al. Effects of Castration on Expression of Lipid Metabolism Genes in the Liver of Korean Cattle. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 28:127-134(2015).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How does the activity of this protein contribute to cellular metabolism? 11/21/2021

The activity of acyl-CoA dehydrogenase medium chain contributes to the breakdown of medium-chain fatty acids to produce energy in cells.

Are there any known inhibitors or activators of this protein? 12/24/2020

There are currently no known inhibitors or activators of acyl-CoA dehydrogenase medium chain protein.

What research is currently being conducted to further understand the function of acyl-CoA dehydrogenase medium chain protein? 02/05/2020

Research is ongoing to further understand the function and regulation of acyl-CoA dehydrogenase medium chain protein, as well as its role in metabolic disorders.

What diseases or disorders are associated with mutations in this protein? 10/27/2018

Mutations in this protein are associated with a variety of metabolic disorders, including medium-chain acyl-CoA dehydrogenase deficiency.

How is the expression of acyl-CoA dehydrogenase medium chain regulated? 09/08/2017

The expression of acyl-CoA dehydrogenase medium chain is regulated by a variety of factors, including gene expression and protein degradation pathways.

Where is acyl-CoA dehydrogenase medium chain protein located within the cell? 06/21/2017

Acyl-CoA dehydrogenase medium chain protein is located in the mitochondrial matrix.

What is the substrate specificity of this protein? 02/21/2016

Acyl-CoA dehydrogenase medium chain protein has specificity for medium-chain fatty acyl-CoA substrates.

What is the structure of this protein and how does it relate to its function? 09/27/2015

Acyl-CoA dehydrogenase medium chain protein has a flavin adenine dinucleotide (FAD)-binding domain that is essential for its function.

What is the function of acyl-CoA dehydrogenase medium chain protein? 08/25/2015

Acyl-CoA dehydrogenase medium chain protein catalyzes the first step in the 尾-oxidation of medium-chain fatty acids.

What are the physiological roles of acyl-CoA dehydrogenase medium chain? 06/25/2015

Acyl-CoA dehydrogenase medium chain plays a key role in energy metabolism and fatty acid oxidation in cells.

Customer Reviews (2)

Write a review
Reviews
04/29/2022

    Demonstrates excellent stability and consistency in long-term storage.

    05/25/2018

      Highly effective in detecting post-translational modifications of the target protein.

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