ACADM
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Official Full Name
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
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Overview
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ACADM; acyl-CoA dehydrogenase, C-4 to C-12 straight chain; acyl Coenzyme A dehydrogenase, C 4 to C 12 straight chain; medium-chain specific acyl-CoA dehydrogenase, mitochondrial; ACAD1; MCAD; MCADH; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chai;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ACADM Related Articles
ACADM involved in several pathways and played different roles in them. We selected most pathways ACADM participated on our site, such as Fatty acid degradation, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACADM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty acid degradation | PECI;ECI2;HADH;ALDH2;GCDHA;GCDH;ACSL3;ACSL1A;ACSBG1 |
Valine, leucine and isoleucine degradation | MCCC1;ALDH9A1B;AUH;BCAT2;MUT;OXCT2;AOX2P;HMGCS1;ACAT1 |
beta-Alanine metabolism | SRM;ALDH3B1;ALDH2;ALDH9A1A.1;SMOX;ALDH7A1;AOC3;ALDH1A3;AOC2 |
Propanoate metabolism | MUT;ACACB;BCKDHB;MLYCD;SUCLG1;ackA;ALDH6A1;SUCLA2;HADHAA |
Metabolic pathways | IDH1;LIPT1;CYP51A1;SPTLC2A;NANS;COQ7;PPAP2B;ACSL4B;PNPLA2 |
Carbon metabolism | PRPS1L1;PGAM1B;MDH2;SDS;ACAT2;TPI1B;GLUD1B;OGDHA;ENO2 |
Fatty acid metabolism | HSD17B12;ACSL5;ACACA;PECR;FADS2;Scd1;HADHB;EHHADH;MCAT |
PPAR signaling pathway | RXRBA;PDPK1B;CYP4A12A;FABP7;FABP1;CYP4A10;MMP1;SCP2A;FABP2 |
ACADM has several biochemical functions, for example, acyl-CoA dehydrogenase activity, electron carrier activity, fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACADM itself. We selected most functions ACADM had, and list some proteins which have the same functions with ACADM. You can find most of the proteins on our site.
Function | Related Protein |
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acyl-CoA dehydrogenase activity | ACADS;ACOXL;ACADM;ACAD8;ACADVL;ACOX2;ACAD9;ACADSB;ACOX3 |
electron carrier activity | IVD;GLRX2;ACAD9;AKR1C4;ACOXL;ACADVL;ACADL;AKR7A3;ME2 |
fatty-acyl-CoA binding | GCDHA;ACADS;ACADSB;ACOX2;ACAD11;ACADVL;ACAD8;PECI;ACOX1 |
flavin adenine dinucleotide binding | FMO1;AOX1;FMO3;FOXRED2;SQLEA;MAOA;AOX4;CYB5R3;AOX3 |
identical protein binding | ACY3;DYNLT1C;CIDEB;RAD51;TRIM21;ADIPOR1;ADIPOQ;NOXO1;GPR50 |
medium-chain-acyl-CoA dehydrogenase activity | ACAD11;ACADM;RSAD1 |
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | GCDHA;ACADVL;GCDH;GCDHB;ACADL;ACOX1;ACAD9;ACOXL;ACAD11 |
ACADM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACADM here. Most of them are supplied by our site. Hope this information will be useful for your research of ACADM.
USP50; USP20; trmn6_yerpe; guaA; HDAC1; CLPP; GABARAPL1
- Q&As
- Reviews
Q&As (10)
Ask a questionThe activity of acyl-CoA dehydrogenase medium chain contributes to the breakdown of medium-chain fatty acids to produce energy in cells.
There are currently no known inhibitors or activators of acyl-CoA dehydrogenase medium chain protein.
Research is ongoing to further understand the function and regulation of acyl-CoA dehydrogenase medium chain protein, as well as its role in metabolic disorders.
Mutations in this protein are associated with a variety of metabolic disorders, including medium-chain acyl-CoA dehydrogenase deficiency.
The expression of acyl-CoA dehydrogenase medium chain is regulated by a variety of factors, including gene expression and protein degradation pathways.
Acyl-CoA dehydrogenase medium chain protein is located in the mitochondrial matrix.
Acyl-CoA dehydrogenase medium chain protein has specificity for medium-chain fatty acyl-CoA substrates.
Acyl-CoA dehydrogenase medium chain protein has a flavin adenine dinucleotide (FAD)-binding domain that is essential for its function.
Acyl-CoA dehydrogenase medium chain protein catalyzes the first step in the 尾-oxidation of medium-chain fatty acids.
Acyl-CoA dehydrogenase medium chain plays a key role in energy metabolism and fatty acid oxidation in cells.
Customer Reviews (2)
Write a reviewDemonstrates excellent stability and consistency in long-term storage.
Highly effective in detecting post-translational modifications of the target protein.
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