ACACA
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Official Full Name
acetyl-CoA carboxylase alpha
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Overview
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. -
Synonyms
ACACA; acetyl-CoA carboxylase alpha; ACAC, ACC, acetyl Coenzyme A carboxylase alpha; acetyl-CoA carboxylase 1; ACC1; acetyl CoA carboxylase 1; ACC-alpha; acetyl-Coenzyme A carboxylase alpha; ACC; ACAC; ACCA; ACACAD;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- Flag|His
- GST
- His
- His (Fc)
- Avi
- His|MBP
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ACACA Related Research Area
ACACA involved in several pathways and played different roles in them. We selected most pathways ACACA participated on our site, such as Fatty acid biosynthesis, Pyruvate metabolism, Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACACA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid biosynthesis | ACSL4B;ACSL3B;ACSL3A;ACAA2;ACSL4A;ACACB;ACSL5;ECHDC2;OXSM |
| Pyruvate metabolism | ALDH9A1A.1;ALDH3A2A;MDH1;ALDH9A1;LDHBA;ALDH2;ALDH7A1;PKLR;ackA |
| Propanoate metabolism | SUCLA2;SUCLG1;PCCB;ACSS2;LDHAL6A;LDHC;MLYCD;BCKDHB;BCKDHA |
| Metabolic pathways | GGPS1;HPGDS;ALOX12B;PIGX;PIGB;NDUFB3;KCNG4;GLS2;ACADSB |
| Fatty acid metabolism | HSD17B12;HADHB;CPT2;HADHAA;ELOVL5;ACADVL;ACOX3;HSD17B12B;ACADS |
| AMPK signaling pathway | G6PC3;PIK3CG;RPTOR;PIK3CA;RAB11B;PFKL;PIK3R1;Scd1;ADIPOQ |
| Insulin signaling pathway | PPARGC1A;CALM1B;SOCS2;PIK3R5;PPP1CAB;FLOT1A;FLOT1;RHOQ;EIF4EA |
ACACA has several biochemical functions, for example, ATP binding, acetyl-CoA carboxylase activity, biotin carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACACA itself. We selected most functions ACACA had, and list some proteins which have the same functions with ACACA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DDX23;OAS1B;RBKS;TOR2A;RPS6KA6;KIF16B;NAGK;AKT2;MAP2K2B |
| acetyl-CoA carboxylase activity | ACACA;ACACB |
| biotin carboxylase activity | PCXB;PCCA;MCCC1;PC;ACACB;ACACA;PCXA |
| metal ion binding | ITGB7;SMYD1A;HAGHL;ZFYVE26;ACLYA;PPTC7;PRKD1;RAB11FIP4A;AMPD3 |
| protein binding | SWAP70;ROR1;APOBEC2A;LMF2;PPID;TMEM231;NRSN1;ZNF488;COPS3 |
ACACA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACACA here. Most of them are supplied by our site. Hope this information will be useful for your research of ACACA.
SIRT1; AKR1B10; ILK; BRCA1; Mylk; CIAO1; MYC; MCC; CHGB; ATXN1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; midostaurin; EEF2K
- Q&As
- Reviews
Q&As (10)
Ask a questionAcetyl-CoA carboxylase alpha protein performs its function through the transfer of a carboxyl group from bicarbonate to acetyl-CoA.
Acetyl-CoA carboxylase alpha protein plays important roles in energy metabolism, fatty acid synthesis, and insulin signaling.
The expression of acetyl-CoA carboxylase alpha protein is regulated by transcriptional and post-transcriptional mechanisms.
Acetyl-CoA carboxylase alpha protein is closely involved in the regulation of lipid metabolism.
Acetyl-CoA carboxylase alpha protein interacts with various cellular components, including cytoskeletal proteins and membrane lipids.
Acetyl-CoA carboxylase alpha protein is implicated in various human diseases, such as obesity, diabetes, and cancer.
The primary function of acetyl-CoA carboxylase alpha protein is to catalyze the conversion of acetyl-CoA to malonyl-CoA.
Modulating the activity of acetyl-CoA carboxylase alpha protein is a potential therapeutic strategy for metabolic disorders and cancer.
Acetyl-CoA carboxylase alpha protein is a multi-subunit enzyme with a biotin carboxylase domain and a carboxyltransferase domain.
The regulation of acetyl-CoA carboxylase alpha protein involves multiple cellular pathways, including AMPK and mTOR signaling.
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