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ACK1

Official Full Name

Activated CDC42 kinase 1
Overview

Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Synonyms

ACK; ACK1; ACK-1; FLJ44758; FLJ45547; p21cdc42Hs; activated CDC42 kinase 1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ACK1-782H	Recombinant Human ACK1, GST tagged	Insect Cell	GST		$623 / 1 mg
Human	TNK233268H	Recombinant Human ACK1 (107-395) Protein, His-tagged	Insect Cell	His		Inquiry

ACK1 involved in several pathways and played different roles in them. We selected most pathways ACK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

ACK1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ACK1 itself. We selected most functions ACK1 had, and list some proteins which have the same functions with ACK1. You can find most of the proteins on our site.

Function	Related Protein

ACK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACK1.