Acot10
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Official Full Name
acyl-CoA thioesterase 10
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Mouse | ACOT10-1196M | Recombinant Mouse ACOT10 Protein | Mammalian Cell | His | ||
Mouse | ACOT10-257M-B | Recombinant Mouse ACOT10 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ACOT10-257M | Recombinant Mouse ACOT10 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
Acot10 involved in several pathways and played different roles in them. We selected most pathways Acot10 participated on our site, such as Fatty Acyl-CoA Biosynthesis, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Acot10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Fatty Acyl-CoA Biosynthesis | ACOT9;ACOT9.2;THEM5;ACOT10;ACOT8;SLC25A1A;ACOT11;ACOT11B;ACOT12 |
Fatty acid, triacylglycerol, and ketone body metabolism | ECI1;ACOT11B;MMAA;AGPAT2;GRHL1;THEM5;CYP7A1;ACAD11;ACOT13 |
Metabolism | DCT;CYP26A1;SAT1B;BRSK2;ARL2;CRYM;PIK3R6;LYVE1;AS3MT |
Metabolism of lipids and lipoproteins | SGMS2;APOA4B.1;AKR1B15;MTF1;FABP1B.1;LMF1;MED8;BCHE;MED18 |
Triglyceride Biosynthesis | ACOT6;ACOT11;ACSF2;ACOT9.1;ACOT11B;ACOT11A;ACOT13;DGAT1B;ACSF3 |
acyl-CoA hydrolysis | ACOT10;ACOT9 |
Acot10 has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity, 2-oxoglutaryl-CoA thioesterase activity, 3-isopropylbut-3-enoyl-CoA thioesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Acot10 itself. We selected most functions Acot10 had, and list some proteins which have the same functions with Acot10. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity | |
2-oxoglutaryl-CoA thioesterase activity | |
3-isopropylbut-3-enoyl-CoA thioesterase activity | |
CoA hydrolase activity | |
acyl-CoA hydrolase activity | ACOT2;ACOT5;ACOT8;ACSBG2;ACOT10;ACOT1;ACOT11 |
carboxylic ester hydrolase activity | ABHD2A;ABHD2B;ABHD2;PNPLA7;ACOT9;CES1C;Cel;NCEH1B;ACOT10 |
glutaryl-CoA hydrolase activity | |
hydrolase activity | Acr;ATP1A1A.1;FURINB;MEIOB;CPSF5;CTDSPL2B;ACTG2;DUB1;ADAM1B |
Acot10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Acot10 here. Most of them are supplied by our site. Hope this information will be useful for your research of Acot10.
- Q&As
- Reviews
Q&As (14)
Ask a questionYes, several natural compounds have been identified that can modulate ACOT10 activity, including resveratrol, curcumin, and quercetin. These compounds have been shown to improve metabolic health and may have therapeutic potential for metabolic disorders.
ACOT10 has been shown to impact mitochondrial function by regulating the production of reactive oxygen species (ROS) and the utilization of fatty acids for energy production. In particular, studies have suggested that ACOT10 may regulate the balance between fatty acid oxidation and the production of ROS, which is important for mitochondrial health and function.
Yes, ACOT10 is a potential therapeutic target for metabolic disorders such as diabetes and obesity. By modulating the activity or expression of ACOT10, it may be possible to regulate lipid metabolism and improve metabolic health.
As of yet, there are no drugs that specifically target ACOT10. However, the protein is a promising target for drug discovery, and researchers are actively searching for compounds that can modulate its activity.
ACOT10 is regulated at the transcriptional and post-transcriptional levels. The expression of the ACOT10 gene is regulated by transcription factors, such as PPARs and LXR, that respond to changes in nutrient availability and metabolic status. Additionally, the activity of ACOT10 can be modified by post-translational modifications, such as phosphorylation and acetylation.
ACOT10 is an acyl-CoA thioesterase that plays a role in the metabolism of fatty acids. It catalyzes the hydrolysis of acyl-CoA esters, which are important intermediates in lipid metabolism. By regulating the breakdown of these compounds, ACOT10 can impact the storage and oxidation of fatty acids within cells.
However, it is important to note that any drug development process involves rigorous testing to ensure safety and efficacy before it can be prescribed to patients.
While ACOT10 may play a role in lipid metabolism, there is currently no evidence to suggest that it can be used for weight loss. However, it may have potential applications in the development of drugs to treat obesity.
There is some evidence to suggest that ACOT10 may be a useful biomarker for certain metabolic disorders. For example, studies have shown that levels of ACOT10 are decreased in patients with type 2 diabetes. However, more research is needed to determine the utility of ACOT10 as a biomarker for other metabolic disorders.
While ACOT10 may play a role in energy metabolism and lipid utilization, its potential for use in sports nutrition or performance enhancement is not well-established. Further research is needed to understand how ACOT10 could impact athletic performance and whether it could be used as a nutritional or therapeutic intervention for athletes.
ACOT10 is found in many different organisms, including mammals, birds, and fish. However, the specific functions of the protein may vary between species.
While more research is needed, ACOT10 may have potential as a diagnostic tool for metabolic disorders. Studies have shown that decreased levels of ACOT10 are associated with type 2 diabetes, and further research may identify other correlations between ACOT10 and metabolic health.
ACOT10 is involved in the regulation of insulin sensitivity and glucose metabolism. By targeting this protein, researchers may be able to develop drugs that improve insulin sensitivity and glucose homeostasis in patients with diabetes.
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