acot8
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  • Official Full Name
  • acyl-CoA thioesterase 8
  • Background
  • The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells.
  • Synonyms
  • ACOT8; acyl-CoA thioesterase 8; peroxisomal acyl CoA thioesterase , peroxisomal acyl CoA thioesterase 1 , PTE1; acyl-coenzyme A thioesterase 8; choloyl CoA hydrolase; hACTE III; hTE; PTE 2; ACTEIII; ACOT8_HUMAN; acyl CoA thioesterase 8; Choloyl coenzyme A thioesterase; Choloyl-coenzyme A thioesterase; hACTE-III; hACTEIII; HIV Nef associated acyl CoA thioesterase; HIV-Nef-associated acyl-CoA thioesterase; HNAACTE; Long chain fatty acyl CoA hydrolase; Palmitoyl CoA hydrolase; Peroxisomal acyl CoA thioesterase 1; Peroxisomal acyl coenzyme A thioester hydrolase 1; Peroxisomal acyl-coenzyme A thioester hydrolase 1; Peroxisomal long chain acyl CoA thioesterase 1; Peroxisomal long-chain acyl-CoA thioesterase 1; PTE 1; PTE-1; PTE-2; PTE1; PTE2; Thioesterase II; thioesterase III; OTTHUMP00000031675; OTTHUMP00000214962; choloyl-CoA hydrolase; palmitoyl-CoA hydrolase; long-chain fatty-acyl-CoA hydrolase; peroxisomal acyl-CoA thioesterase 1; HIV
Cat.#:ACOT8-906HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACOT8 Protein, His-tagged
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Cat.#:ACOT8-170HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ACOT8 Protein, GST-Tagged
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Cat.#:ACOT8-3141HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ACOT8, His-tagged
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Cat.#:ACOT8-7604HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACOT8, His-tagged
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Cat.#:ACOT8-1206MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ACOT8 Protein
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Cat.#:Acot8-3140MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Acot8, His-tagged
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Cat.#:ACOT8-213RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ACOT8 Protein, His-tagged
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Cat.#:ACOT8-1581ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ACOT8
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Cat.#:ACOT8-9086HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ACOT8 293 Cell Lysate
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Involved Pathway

ACOT8 involved in several pathways and played different roles in them. We selected most pathways ACOT8 participated on our site, such as Beta-oxidation of pristanoyl-CoA, Beta-oxidation of very long chain fatty acids, Bile acid and bile salt metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Beta-oxidation of pristanoyl-CoA
CRAT; ACOT8; SCP2B
Beta-oxidation of very long chain fatty acids
ACOT8; CRAT
Bile acid and bile salt metabolism
AKR1C4; BRSK2; AKR1C21; SLCO1B1; SLC27A5; CYP7A1; ACOT8; SCP2B; SLC27A2; AKR1C2
Fatty Acyl-CoA Biosynthesis
ACOT2; ELOVL1A; ACOT8; THEM5; ACOT9; ACOT7; ACOT9.1; ACOT12; ACOT11A; ACOT9.2
Fatty acid, triacylglycerol, and ketone body metabolism
MED19; DGAT1B; CDK8; MED8; MED29; ACOT12; CYP7A1; MED22; MED25; AGPAT6
Metabolic pathways
BDH2; LDHAL6B; MAT2B; UCK2A; NDUFA4L2; ACSM5; ACY1; GALNTL5; ITGB1BP3; DHRS3
Metabolism
APOA4B.2; OAZ3; APOA4B.1; ACOT13; TIMMDC1; PAOX; SLC27A5; SLC25A27; CPNE1; FMODA
Metabolism of lipids and lipoproteins
CEPT1A; ARSD; GLTPA; CDS1; PLD6; FABP11A; CPNE6; ARSF; NEU3; SUMF2

Protein Function

ACOT8 has several biochemical functions, for example, acyl-CoA hydrolase activity, carboxylic ester hydrolase activity, choloyl-CoA hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOT8 itself. We selected most functions ACOT8 had, and list some proteins which have the same functions with ACOT8. You can find most of the proteins on our site.
Function
Related Protein
Function acyl-CoA hydrolase activity
Related Protein ACOT11; ACOT1; ACOT5; ACOT10; ACOT2; ACOT8; ACSBG2
Function carboxylic ester hydrolase activity
Related Protein FAM135B; ACOT8; ACOT1; ACOT9; AADACL2; ACOT2; ACOT12; NOTUM1A; BAAT; PNPLA7
Function choloyl-CoA hydrolase activity
Related Protein ACOT8
Function medium-chain acyl-CoA hydrolase activity
Related Protein ACOT8; BAAT
Function palmitoyl-CoA hydrolase activity
Related Protein THEM5; ACOT5; ACOT2; THEM4; BAAT; ACOT8; GNPAT; PPT1; ACOT1; ACOT7
Function protein binding
Related Protein MAP1B; ZC3H12A; BRAP; MRFAP1L1; APOB; PCSK2; TRADD; KRT83; ASCL1; TBC1D24
Function receptor binding
Related Protein ANXA1; F2; FGF20A; SERPINE1; LTA; TNFSF18; APOL2; CCDC129; RARRES2; CD160

Interacting Protein

ACOT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOT8.
nef; PEX5; REL; 15-deoxy-delta(12,14; midostaurin; MYC; US3; Nedd1; P