acot8
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  • Official Full Name
  • acyl-CoA thioesterase 8
  • Background
  • The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells.
  • Synonyms
  • ACOT8; acyl-CoA thioesterase 8; peroxisomal acyl CoA thioesterase , peroxisomal acyl CoA thioesterase 1 , PTE1; acyl-coenzyme A thioesterase 8; choloyl CoA hydrolase; hACTE III; hTE; PTE 2; ACTEIII; ACOT8_HUMAN; acyl CoA thioesterase 8; Choloyl coenzyme A thioesterase; Choloyl-coenzyme A thioesterase; hACTE-III; hACTEIII; HIV Nef associated acyl CoA thioesterase; HIV-Nef-associated acyl-CoA thioesterase; HNAACTE; Long chain fatty acyl CoA hydrolase; Palmitoyl CoA hydrolase; Peroxisomal acyl CoA thioesterase 1; Peroxisomal acyl coenzyme A thioester hydrolase 1; Peroxisomal acyl-coenzyme A thioester hydrolase 1; Peroxisomal long chain acyl CoA thioesterase 1; Peroxisomal long-chain acyl-CoA thioesterase 1; PTE 1; PTE-1; PTE-2; PTE1; PTE2; Thioesterase II; thioesterase III; OTTHUMP00000031675; OTTHUMP00000214962; choloyl-CoA hydrolase; palmitoyl-CoA hydrolase; long-chain fatty-acyl-CoA hydrolase; peroxisomal acyl-CoA thioesterase 1; HIV
Cat.#:ACOT8-906HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACOT8 Protein, His-tagged
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Cat.#:ACOT8-170HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ACOT8 Protein, GST-Tagged
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Cat.#:ACOT8-3141HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ACOT8, His-tagged
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Cat.#:ACOT8-7604HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACOT8, His-tagged
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Cat.#:ACOT8-1206MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ACOT8 Protein
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Cat.#:Acot8-3140MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Acot8, His-tagged
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Cat.#:ACOT8-213RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ACOT8 Protein, His-tagged
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Cat.#:ACOT8-1581ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ACOT8
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Cat.#:ACOT8-9086HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ACOT8 293 Cell Lysate
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Involved Pathway

ACOT8 involved in several pathways and played different roles in them. We selected most pathways ACOT8 participated on our site, such as Beta-oxidation of pristanoyl-CoA, Beta-oxidation of very long chain fatty acids, Bile acid and bile salt metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOT8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Beta-oxidation of pristanoyl-CoA
ACOT8; SCP2B; CRAT
Beta-oxidation of very long chain fatty acids
CRAT; ACOT8
Bile acid and bile salt metabolism
NCOA2; AKR1C2; AKR1C6; SLC27A2A; CYP27A1; CYP46A1; SLC27A2; Alb; CYP8B2; AKR1C4
Fatty Acyl-CoA Biosynthesis
ELOVL1A; SLC25A1A; ACOT6; ACOT7; ACOT12; ACOT9.1; ACSF3; ACSF2; ACOT11A; ACOT8
Fatty acid, triacylglycerol, and ketone body metabolism
MED29; MED22; Agmo; DGAT1B; PLIN2; ACOT10; MED19; THEM5; MED21; CPT2
Metabolic pathways
ATP6V1G3; POLR2J2; PKM; GALCA; PLD4; AANAT1; PPAP2CB; DAO.3; HYAL2; PKM2
Metabolism
APOEA; AQP1A.2; CYP2B6; GYG1A; SACM1LA; ADAL; MARCKSB; CYP4F12; ACSM1; NUDT16
Metabolism of lipids and lipoproteins
APOEA; CERS3B; Alb; ACOT6; PITPNB; SACM1LB; SACM1L; LBR; ACOT9.2; APOA4B.2

Protein Function

ACOT8 has several biochemical functions, for example, acyl-CoA hydrolase activity, carboxylic ester hydrolase activity, choloyl-CoA hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOT8 itself. We selected most functions ACOT8 had, and list some proteins which have the same functions with ACOT8. You can find most of the proteins on our site.
Function
Related Protein
Function acyl-CoA hydrolase activity
Related Protein ACOT1; ACOT2; ACSBG2; ACOT5; ACOT8; ACOT10; ACOT11
Function carboxylic ester hydrolase activity
Related Protein NCEH1B; ABHD2; ACOT6; LIPCA; CES1; BAAT; Ces2e; Cel; ACOT1; LYPLAL1
Function choloyl-CoA hydrolase activity
Related Protein ACOT8
Function medium-chain acyl-CoA hydrolase activity
Related Protein ACOT8; BAAT
Function palmitoyl-CoA hydrolase activity
Related Protein BAAT; ACOT2; GNPAT; PPT1; ACOT7; ACOT5; ACOT1; THEM4; ACOT8; THEM5
Function protein binding
Related Protein APOBEC3H; PCDH18B; CCDC112; IL6ST; ADAM33; LRRC4C; TP63; LPAR2; CD3E; MBD1
Function receptor binding
Related Protein WNT4A; PPP2R4; SLC9A3R1; ECI2; GIPC1; CLCF1; PLG; HIST2H3C2; RARRES2; ADM

Interacting Protein

ACOT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOT8.
nef; PEX5; REL; 15-deoxy-delta(12,14; midostaurin; MYC; US3; Nedd1; P