ACR
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Official Full Name
acrosin
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Overview
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. -
Synonyms
ACR; acrosin; preproacrosin; Acrosin precursor; ACRS; Proacrosin;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Common turkey
- Goat
- Human
- Mouse
- Rabbit
- Rat
- Wild turkey
- E.coli
- E.Coli or Yeast
- HEK293
- Insect Cell
- Mammalian Cell
- Yeast
- GST
- His
- His (Fc)
- Avi
- Myc
- MBP
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ACR Related Articles
ACR involved in several pathways and played different roles in them. We selected most pathways ACR participated on our site, such as Acrosome Reaction, Fertilization, Reproduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acrosome Reaction | |
| Fertilization | CATSPERG1;OVGP1;IZUMO4;ZP2;CATSPERG2;CATSPER1;Acr;CATSPER3;IZUMO1 |
| Reproduction | Acr;IZUMO1;ADAM30;CATSPERG1;ADAM20;TMEM146;ZP2;ZP3;CATSPER2 |
ACR has several biochemical functions, for example, hydrolase activity, mannose binding, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACR itself. We selected most functions ACR had, and list some proteins which have the same functions with ACR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity | PSMB8F;PTPN20;IRGM;DHX34;ATP13A;SNRNP200;ATP8B1;C6AST1;CTSL1B |
| mannose binding | Acr;MBL2;M6PR;MBL1;CD207;CD209A;CD209B;MAN2B1;CLEC4M |
| peptidase activity | DHH;CAPN2B;LTA4H;PCSK5B;CTSSA;PROCA;MMP14B;NAPSA;Gzmg |
| protein binding | MTERF;CLASP1;CATSPERG2;PRAP1;SMARCE1;SFPI1;PRKCD;TBX5A;UBR1 |
| serine-type endopeptidase activity | F9A;PRSS7;APEH;PROCA;MCPT9;TMPRSS2;PRSS22;C1S;GZMK |
| serine-type peptidase activity | KLK1B22;TPSB2;IRBP;PLAUB;GZMM;GZMB;PRSS40;F9B;GM5077 |
ACR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACR here. Most of them are supplied by our site. Hope this information will be useful for your research of ACR.
- Q&As
- Reviews
Q&As (10)
Ask a questionThe Acr protein is a transmembrane protein that spans the bacterial cell membrane and pumps antibiotics out of the cell.
The expression of the Acr gene can be regulated by several mechanisms, including transcriptional regulation and post-transcriptional regulation.
The Acr protein pumps antibiotics out of bacterial cells, which reduces the concentration of the antibiotic inside the cell and makes it less effective.
The Acr gene confers resistance to multiple types of antibiotics, including tetracyclines and fluoroquinolones.
Yes, there are several inhibitors of the Acr protein that have been developed, including phenylalanine-arginine beta-naphthylamide (PAβN) and carbonyl cyanide m-chlorophenylhydrazone (CCCP).
The Acr gene can be transferred between bacterial cells through horizontal gene transfer mechanisms, such as conjugation, transformation, and transduction.
The periplasmic adapter protein is a key component of the efflux pump system that links the outer membrane channel protein to the Acr protein in the inner membrane.
The expression of the Acr gene can be regulated at the post-transcriptional level by small RNAs that bind to the mRNA transcript and either stabilize or degrade it.
Mutations in the coding sequence of the Acr gene can affect the function of the Acr protein and contribute to antibiotic resistance, particularly mutations that affect the extracellular loop region.
Yes, the Acr gene can be used as a diagnostic tool for antibiotic resistance by detecting the presence of the gene in bacterial samples.
Customer Reviews (5)
Write a reviewThe delivery speed is very fast, and I can start my experiment quickly.
The protein quality is very high and can meet my experimental needs.
The packaging is good, and the protein has not been damaged.
The product description is very clear, and I can easily use the protein.
The manufacturer provides excellent technical support and can solve my problems.
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