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ACSS2

  • Official Full Name

    acyl-CoA synthetase short-chain family member 2

  • Overview

    This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.
  • Synonyms

    ACSS2; acyl-CoA synthetase short-chain family member 2; ACAS2, acetyl Coenzyme A synthetase 2 (ADP forming); acetyl-coenzyme A synthetase, cytoplasmic; AceCS; ACS; ACSA; dJ1161H23.1; cytoplasmic; ACAS2; Acetate CoA ligase; Acetate thiokinase; Acetate--CoA ligase; Acetyl CoA synthetase; Acetyl Coenzyme A synthetase 2 (ADP forming); Acetyl coenzyme A synthetase cytoplasmic; Acetyl-CoA synthetase; Acetyl-coenzyme A synthetase; ACSA_HUMAN; Acyl activating enzyme; Acyl CoA synthetase short chain family member 2; Acyl-activating enzyme; Cytoplasmic acetyl coenzyme A synthetase; MYH7B; acetate-CoA ligase; cytoplasmic acetyl-coenzyme A synthetase; acetyl-Coenzyme A synthetase 2 (ADP forming);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACSS2-209H Recombinant Human ACSS2 Protein, GST-tagged Wheat Germ GST
Human ACSS2-210H Recombinant Human ACSS2 Protein, GST-tagged Wheat Germ GST
Human ACSS2-9068HCL Recombinant Human ACSS2 293 Cell Lysate HEK293 N/A
Human ACSS2-84HFL Recombinant Full Length Human ACSS2 Protein, C-Flag-tagged Mammalian cells Flag
Human ACSS2-4280H Recombinant Human ACSS2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACSS2-814HF Recombinant Full Length Human ACSS2 Protein, GST-tagged In Vitro Cell Free System GST 606 amino acids
Human ACSS2-67H Recombinant Human ACSS2 Protein, His-tagged E.coli N-His Ala489-Gln701
Human ACSS2-264H Recombinant Human ACSS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ACSS2-4019H Recombinant Human ACSS2 protein, His-tagged E.coli His 18-191 aa
Human ACSS2-0280H Recombinant Human ACSS2 Protein (G2-Q701), Tag Free E.coli No tag G2-Q701
Human ACSS2-0281H Recombinant Human ACSS2 Protein (G2-Q701), His tagged E.coli His G2-Q701
Human ACSS2-264H-B Recombinant Human ACSS2 Protein Pre-coupled Magnetic Beads HEK293
Mouse ACSS2-1236M Recombinant Mouse ACSS2 Protein Mammalian Cell His
Mouse ACSS2-1107M Recombinant Mouse ACSS2 Protein, His-tagged E.coli His
Mouse Acss2-68M Recombinant Mouse Acss2 Protein, His-tagged E.coli N-His Pro492-Gln701
Mouse ACSS2-279M-B Recombinant Mouse ACSS2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Acss2-1513M Recombinant Mouse Acss2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ACSS2-279M Recombinant Mouse ACSS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ACSS2-219R Recombinant Rhesus monkey ACSS2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ACSS2-47R-B Recombinant Rhesus Macaque ACSS2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ACSS2-47R Recombinant Rhesus Macaque ACSS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ACSS2-752Z Recombinant Zebrafish ACSS2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ACSS2 involved in several pathways and played different roles in them. We selected most pathways ACSS2 participated on our site, such as Glycolysis / Gluconeogenesis, Pyruvate metabolism, Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisFBP1A;ALDH2.1;PKMB;ALDH2;LDHA;DLDH;PFKMA;LDHB;ALDH9A1
Pyruvate metabolismALDH9A1B;PKM2;LDHBB;PDK2;PDK4;hchA;ME2;LDHAL6A;PKMA
Propanoate metabolismSUCLG1;LDHC;ACSS1;LDHBA;PCCB;HADHAB;HIBCH;LDHB;MUT
Metabolic pathwaysHPRT1;LPCAT4;ALDH9A1A.1;HIBCH;SYNJ2;NT5C3B;DCXR;MTM1;CYP2B19
Carbon metabolismPFKL;GPT2L;PDHA1A;PRPS2;ENO1A;FH1;DLST;PKLR;MTHFR

ACSS2 has several biochemical functions, for example, AMP binding, ATP binding, acetate-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSS2 itself. We selected most functions ACSS2 had, and list some proteins which have the same functions with ACSS2. You can find most of the proteins on our site.

Function Related Protein
AMP bindingACSS2;FBP1;PYGL;CYB5R3;PYGM;PRKAG2;PRKAG1;ACSS1;PRPS1
ATP bindingIARS;PAPSS1;SMC1B;NEK12;SCYL3;RUNX2;XYLB;EP400;ERCC6L
acetate-CoA ligase activityACSS3;ACSS2;ACSS1

ACSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSS2.

q2i360_hbv; purT; UPF1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; Smchd1; CTR9

  • Q&As
  • Reviews

Q&As (10)

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What is the role of ACSS2 protein in liver metabolism? 10/16/2021

ACSS2 protein is required for normal liver metabolism and the synthesis of ketone bodies, which are important energy sources during fasting and starvation

What is the effect of ACSS2 protein inhibition on the response to hypoxia? 05/27/2021

Inhibition of ACSS2 protein activity sensitizes cancer cells to hypoxia, a condition of low oxygen availability that promotes tumor progression and resistance to therapy.

What is the relationship between ACSS2 protein and fatty acid metabolism? 10/30/2020

ACSS2 protein plays a critical role in linking fatty acid metabolism to oxidative metabolism in the mitochondria of mammalian cells.

What is the role of ACSS2 protein in adipose tissue? 09/14/2020

ACSS2 protein plays a key role in adipose tissue metabolism by regulating the production of adipokines, hormones that are involved in the regulation of energy homeostasis.

What is the relationship between ACSS2 protein and aging? 08/07/2020

ACSS2 protein expression has been shown to decline with age, and the loss of ACSS2 protein activity may contribute to age-related metabolic dysfunction.

What is the relationship between ACSS2 protein and circadian rhythms? 05/23/2020

ACSS2 protein expression is regulated by circadian rhythms, and ACSS2 protein activity may play a role in the circadian regulation of metabolism.

What is the relationship between ACSS2 protein and the gut-brain axis? 02/27/2020

Emerging evidence suggests that ACSS2 protein may play a role in the gut-brain axis, which is the bidirectional communication between the gut microbiome and the central nervous system.

What is the relationship between ACSS2 protein and the gut microbiome? 09/18/2019

ACSS2 protein expression is regulated by the gut microbiome, and ACSS2 protein activity may play a role in the interaction between the host and the microbiome.

What is the effect of ACSS2 protein deficiency on macrophage function? 06/11/2019

Deficiency of ACSS2 protein activity in macrophages has been shown to impair phagocytosis and reduce the production of inflammatory cytokines.

What is the role of ACSS2 protein in the regulation of fatty acid oxidation? 05/04/2019

ACSS2 protein is involved in the regulation of fatty acid oxidation by providing the acetyl-CoA needed for entry into the TCA cycle.

Customer Reviews (5)

Write a review
Reviews
01/09/2022

    It showed superior stability, retaining its activity even under challenging experimental conditions. It has significantly improved the reliability of our assays.

    11/03/2021

      It's a game-changer for any lab seeking efficiency.

      09/17/2020

        This protein is a rock star! It consistently delivers outstanding results with a smile.

        06/12/2019

          The quality-price ratio of this protein is truly commendable.

          04/28/2018

            Its reliable and reproducible results have facilitated precise data acquisition, supporting the validity and integrity of our experimental findings.

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