ACSF3
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Official Full Name
acyl-CoA synthetase family member 3
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Synonyms
ACSF3; acyl-CoA synthetase family member 3; acyl-CoA synthetase family member 3, mitochondrial; Acyl CoA synthetase family member 3; Acyl CoA synthetase family member 3 mitochondrial; FLJ39242; Hypothetical protein LOC197322;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ACSF3-194H | Recombinant Human ACSF3 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ACSF3-1001HCL | Recombinant Human ACSF3 cell lysate | N/A |
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| Human | ACSF3-788HF | Recombinant Full Length Human ACSF3 Protein, GST-tagged | In Vitro Cell Free System | GST | 576 amino acids |
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| Mouse | ACSF3-1224M | Recombinant Mouse ACSF3 Protein | Mammalian Cell | His |
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| Mouse | ACSF3-271M | Recombinant Mouse ACSF3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ACSF3-271M-B | Recombinant Mouse ACSF3 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
ACSF3 involved in several pathways and played different roles in them. We selected most pathways ACSF3 participated on our site, such as Fatty Acyl-CoA Biosynthesis, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty Acyl-CoA Biosynthesis | ACOT11;ACOT9.1;ACOT12;ACOT9;ACSF2;ACOT7;ACOT11B;ACOT9.2;ELOVL1A |
| Fatty acid, triacylglycerol, and ketone body metabolism | MED7;CYP4A11;ACOT11B;MED20;MED15;MED21;TMEM195;ACOT9.2;MED16 |
| Metabolism | LYPLA1;SLC25A15B;ARSK;SLC25A1;HAS3;NHLRC1;SLC2A3;NUBP2;ISCU |
| Metabolism of lipids and lipoproteins | MED29;DPEP1;APOA4B.1;CYP27A1;SLC25A20;MED18;PPM1LA;FAAH2A;BCHE |
| Synthesis of very long-chain fatty acyl-CoAs | ELOVL1A;ACSF3 |
| Triglyceride Biosynthesis | ELOVL1A;ACOT9.2;ACSF3;SLC25A1;DGAT1B;ACOT11A;ACOT12;ACOT10;THEM5 |
| Valine, leucine and isoleucine degradation | ALDH9A1B;AUH;ACADS;HIBCH;ALDH2;OXCT1B;HIBADH;ACADSB;ACAA1A |
ACSF3 has several biochemical functions, for example, ATP binding, acid-thiol ligase activity, malonyl-CoA synthetase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSF3 itself. We selected most functions ACSF3 had, and list some proteins which have the same functions with ACSF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CTPS2;FASTK;CHD1L;DDX39;ATP6V1B2;ABCC2;SPO11;DDX56;CMPK |
| acid-thiol ligase activity | AASDH;ACSF3 |
| malonyl-CoA synthetase activity |
ACSF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSF3.
HAUS2; SIRT4
- Q&As
- Reviews
Q&As (10)
Ask a questionSeveral studies have found a correlation between ACSF3 gene expression and obesity, with higher ACSF3 expression levels observed in obese individuals.
ACSF3 catalyzes the activation of fatty acids for use in phospholipid synthesis, a crucial component of membrane structure and function.
ACSF3 is involved in the production of acetyl-CoA, which is a substrate for the enzyme choline acetyltransferase (ChAT) that catalyzes the formation of acetylcholine from choline and acetyl-CoA. Therefore, ACSF3 indirectly contributes to the production of acetylcholine, which is an important neurotransmitter in the nervous system.
ACSF3 catalyzes the activation of long-chain fatty acids by transferring the fatty acid to CoA, forming acyl-CoA, which can be used in various metabolic processes.
ACSF3 interacts with several proteins, including fatty acid transport proteins, diacylglycerol acyltransferases, and peroxisome proliferator-activated receptors.
Dysregulation of ACSF3 gene expression has been linked to several metabolic disorders, including obesity, insulin resistance, and type 2 diabetes.
ACSF3 has been shown to activate branched-chain fatty acids, such as phytanic acid and pristanic acid, which are derived from dietary sources or produced by gut microbiota. ACSF3 activates these fatty acids by converting them into their respective CoA esters, which can then be further metabolized in the peroxisomes.
ACSF3 gene expression is regulated by various factors, including hormones, transcription factors, and epigenetic modifications.
The expression of ACSF3 can be regulated at both the transcriptional and post-transcriptional levels. Transcriptional regulation can be mediated by factors such as peroxisome proliferator-activated receptor (PPAR) and sterol regulatory element-binding protein (SREBP), which can activate or repress the transcription of the ACSF3 gene. Post-transcriptional regulation can occur through mechanisms such as alternative splicing, microRNA-mediated degradation, and protein degradation via the ubiquitin-proteasome system.
ACSF3 is primarily localized in the mitochondria of cells, specifically in the mitochondrial outer membrane, where it functions in the beta-oxidation of fatty acids.
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