ACSM2A
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Official Full Name
acyl-CoA synthetase medium-chain family member 2A
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Synonyms
ACSM2A;acyl-CoA synthetase medium-chain family member 2A;32017;ENSG00000183747;ACSM2;A-923A4.1;16p12.3;FLJ34659, MGC150530;acyl-coenzyme A synthetase ACSM2A, mitochondrial;acyl-coenzyme A synthetase ACSM2A, mitochondrial;butyrate--CoA ligase 2A;butyryl-coenzyme A synthetase 2A;Homolog of rat kidney-specific (KS);middle-chain acyl-CoA synthetase 2A;EC 6.2.1.2;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ACSM2A-205H | Recombinant Human ACSM2A Protein, GST-tagged | Wheat Germ | GST |
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| Human | ACSM2A-808HF | Recombinant Full Length Human ACSM2A Protein, GST-tagged | In Vitro Cell Free System | GST | 577 amino acids |
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| Rat | Acsm2a-3135R | Recombinant Rat Acsm2a, His-tagged | E.Coli or Yeast | His | 572 |
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- Involved Pathway
- Protein Function
- Interacting Protein
ACSM2A involved in several pathways and played different roles in them. We selected most pathways ACSM2A participated on our site, such as Butanoate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSM2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Butanoate metabolism | ABAT;HMGCLL1;ACSM3;ACSM5;HADHAB;ACAT1;ACSM1;EHHADH;AACS |
| Metabolic pathways | NDUFA3;HPDA;SDHD;AKR1B10;AKR1C3;NT5C1BA;NDUFAB1A;MINPP1;PCCA |
ACSM2A has several biochemical functions, for example, ATP binding, butyrate-CoA ligase activity, catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSM2A itself. We selected most functions ACSM2A had, and list some proteins which have the same functions with ACSM2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PAPSS2A;KIF3B;DDX25;NAIP1;CDKL2;DHX16;ETNK2;SRR;EIF2AK3 |
| butyrate-CoA ligase activity | ACSM1;Acsm2a;ACSM2B;ACSM5;AACS;ACSM2;ACSM3;ACSM4;PPP1CA |
| catalytic activity | ALPI.2;GLULB;SGSH;PPM1NB;ACLYA;EML5;SPTLC2A;FHIT;LGI3 |
| metal ion binding | ZNF12;ZNF789;ZMYND17;ZFP551;TRIM35-31;ARHGAP29;PRDM6;MAP2K5;NUPL2 |
| molecular_function | TLE4;ACBD5;CCDC46;GM16515;TSPAN35;FAM184A;FAM180A;RGCC;GM13304 |
ACSM2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSM2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSM2A.
- Q&As
- Reviews
Q&As (10)
Ask a questionRecent studies have suggested that ACSM2A plays a critical role in cancer metabolism by regulating the uptake and utilization of fatty acids by cancer cells.
ACSM2A has been shown to be highly expressed in skeletal muscle and may play a role in regulating muscle function and metabolism. Studies have suggested that ACSM2A may be involved in the regulation of glucose uptake and glycogen synthesis in muscle cells.
ACSM2A is known to interact with several cellular proteins and signaling pathways, including the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors and the AMP-activated protein kinase (AMPK) pathway. Further investigation is needed to fully understand the functional significance of these interactions.
ACSM2A-mediated insulin resistance is thought to be due to the accumulation of lipid intermediates, such as diacylglycerols and ceramides, which interfere with insulin signaling.
ACSM2A expression has been shown to be upregulated in various types of cancer, including breast cancer and pancreatic cancer, and may serve as a potential therapeutic target for cancer treatment.
Recent studies have suggested that ACSM2A expression is regulated by the tumor microenvironment, including hypoxia and inflammatory cytokines, in cancer cells.
Inhibition of ACSM2A activity has been shown to suppress the growth and survival of colorectal cancer cells, suggesting that ACSM2A may serve as a potential therapeutic target for colorectal cancer treatment.
The precise mechanism by which ACSM2A regulates tumor growth and survival in cancer cells is not fully understood. However, recent studies suggest that ACSM2A may modulate fatty acid metabolism and mitochondrial function to support cancer cell growth and survival.
ACSM2A has been implicated in the development of liver steatosis by promoting the uptake and accumulation of fatty acids in hepatocytes.
ACSM2A deficiency has been shown to impair mitochondrial β-oxidation and energy metabolism, leading to metabolic dysfunction.
Customer Reviews (5)
Write a reviewSo grateful for its performance!
It seamlessly integrates into our experimental systems, enabling precise control and manipulation. It has greatly expanded the scope of our investigations.
The functionality of this protein is outstanding.
Affordable pricing without compromising on quality. Highly satisfied with the product.
We are exceedingly satisfied with the quality of this protein.
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