actg1
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  • Official Full Name
  • actin, gamma 1
  • Background
  • Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • ACTG1; actin, gamma 1; ACTG, deafness, autosomal dominant 20; deafness, autosomal dominant 26 , DFNA20, DFNA26; actin, cytoplasmic 2; cytoplasmic 2; N-terminally processed; ACT; ACTB; ACTG; ACTG_HUMAN; Actin; Actin, gamma 1 propeptide; Cytoskeletal gamma actin; Deafness, autosomal dominant 20; Deafness, autosomal dominant 26; DFNA20; DFNA26; Gamma-actin; cytoskeletal gamma-actin
Cat.#:ACTG1-162HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTG1 protein, T7-tagged
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Cat.#:ACTG1-216HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACTG1 Protein, GST-tagged
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Cat.#:ACTg1-3087HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTg1, His-tagged, GST-tagged
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Cat.#:ACTG1-60HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Actin, Gamma 1, T7-tagged
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Cat.#:ACTG1-6898HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTG1 protein, His-tagged
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Cat.#:ACTG1-1242MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ACTG1 Protein
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Cat.#:Actg1-3094MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Actg1, His-tagged
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Cat.#:ACTG1-480RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACTG1 Protein
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Cat.#:ACTG1-1750CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACTG1
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Cat.#:ACTG1-9064HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ACTG1 293 Cell Lysate
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Involved Pathway

ACTG1 involved in several pathways and played different roles in them. We selected most pathways ACTG1 participated on our site, such as Rap signaling pathway, Phagosome, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
MAGI2; PLCB1; PIK3CA; FGF2; VEGFC; VASP; PIK3R3; ANGPT1; ACTG1; THBS1
Phagosome
MHC2DEB; BF1; ATP6V1B1; MSR1; STX7; THBS4; MARCO; FCGR2B; COLEC12; NCF2
Hippo signaling pathway
BMP6; WNT11; PPP2CB; SMAD2; BMP4; DVL3; FGF1; AXIN1; BIRC2; FZD9
Focal adhesion
ACTN4; RHOAA; FLT4; ELK1; PIK3R1; COL11A2; RAP1AA; LAMA1; AKT2; PIK3CG
Adherens junction
PTBP3; LMO7; PTPRJA; SMAD4; VCLA; PTPRF; SRC; FYNA; SNAI2; INSRA
Tight junction
EPB41L3; PPP2R2BB; MYHC4; CLDN7; AKT1; NRAS; CASKB; HRAS; MYH9; TJP2
Platelet activation
PRKACG; FERMT3; ARHGEF12; RAP1B; ROCK2; MAPK11; GNAI2; P2RY12; RHOA; PIK3CD
Leukocyte transendothelial migration
PIK3R1; PLCG1; MYLPF; NIPAL1; ACTN3; MYL12B; THY1; MLLT4; RASSF5; PIK3R3
Regulation of actin cytoskeleton
CYFIP1; FGF12; RRAS2; HRASB; PIP5K2; INS; RAF1B; WASB; ITGAE; MAPK3
Thyroid hormone signaling pathway
PRKACA; PRKACB; SLC2A1; MED30; MED1; NCOA1; PLCB4; BAD; AKT1; SRC
Oxytocin signaling pathway
TRPM2; MAPK7; CAMK2D; CACNG6; MYLK2; PIK3R2; CAMK2B; GUCY1B3; PRKAG2; PLCB1
Bacterial invasion of epithelial cells
FN1; ITGB1; WASL; SEPT9; SEPT12; ELMO1; PTK2; PIK3R2; PIK3CA; SEPT6
Vibrio cholerae infection
ATP6V1B1; ATP6V1C2; ATP6V1E1; ATP6V1B2; PRKCA; KDELR2; ATP6V0D1; PRKACG; PDIA4; TJP1
Pathogenic Escherichia coli infection
TUBB2B; WAS; KRT18; CLDN1; NCK2; TUBA3E; TUBB7P; RHOA; FYN; CD14
Shigellosis
RHOG; ROCK2; CTTN; IKBKB; UBE2D2; ABL1; IKBKG; ATG5; WAS; U2AF1
Salmonella infection
ACTG1; RHOGC; NLRC4; MAPK12A; RHOGD; WASB; RAC1A; RAB7; IFNGR2; IL6
Influenza A
GSK3B; HSPA1B; HSPA6; IL1A; IFNB1; DNAJB1; IVNS1ABP; Ifna15; NXT1; NLRX1
Proteoglycans in cancer
PTK2; HSPB2; FAS; SDC4; THBS1; COL21A1; TLR4; HOXD10; HPSE; PDPK1
Hypertrophic cardiomyopathy (HCM)
ITGA1; RYR2; TGFB1; ITGAV; ITGA5; CACNA2D4; ACTC1; ITGA9; PRKAB1; PRKAG2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
CACNG1; CACNB1; CACNA2D2; ITGA8; GJA1; CACNG6; JUP; SLC8A1; CACNB4; CTNNA1
Dilated cardiomyopathy
MYL2; PRKACB; ITGA5; IGF1; MYH7; ITGA1; Adcy4; TGFB3; ITGB8; ITGB1
Viral myocarditis
EIF4G3; CXADR; CCND1; HLA-DRB5; ABL2; HLA-G; FYN; CYCS; RAC2; RAC1

Protein Function

ACTG1 has several biochemical functions, for example, ATP binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTG1 itself. We selected most functions ACTG1 had, and list some proteins which have the same functions with ACTG1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DGKB; DDX5; ACSM2; GK2; CHD7; ACTC1B; PAPD4; HK3; PAK2B; ABCG1
Function identical protein binding
Related Protein RASSF1; CEP72; CSK; SLC2A1; AIRE; RILPL2; DRG1; SHARPIN; EPHA4; HCN4
Function protein binding
Related Protein PIK3CG; PGLS; TRIM27; BCL2L16; IL23R; HNRNPAB; UBE3A; SSBP1; KRTAP9-4; VAMP8
Function structural constituent of cytoskeleton
Related Protein KRT15; ACTG1; TUBA1A; INA; TPM1; ACTL7B; TUBA2; TUBA3E; KRT16; TUBA7L
Function ubiquitin protein ligase binding
Related Protein PRKAR1A; SCAMP3; CUL1A; RFFL; SNCAIP; FBXW7; IKBKE; HSPA9; BAG6; AXIN2

Interacting Protein

ACTG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTG1.
ACTB; DSTN; CFL1

ACTG1 Related Articles

Verloes, A; Di Donato, N; et al. Baraitser-Winter cerebrofrontofacial syndrome: delineation of the spectrum in 42 cases. EUROPEAN JOURNAL OF HUMAN GENETICS 23:292-301(2015).
Marques, F; Heredia, R; et al. Partial Trisomy 17q and Partial Monosomy 20q in a Boy with Craniosynostosis. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:412-416(2015).