actg2
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  • Official Full Name
  • actin, gamma 2, smooth muscle, enteric
  • Background
  • Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the;cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are;found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist;in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes;actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript;variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of;this gene is formed by removal of two N-terminal peptides.
  • Synonyms
  • ACTG2; actin, gamma 2, smooth muscle, enteric; ACTA3, ACTL3; actin, gamma-enteric smooth muscle; ACTSG; alpha-actin 3; alpha-actin-3; gamma-2-actin; actin-like protein; smooth muscle gamma actin; smooth muscle gamma-actin; ACT; ACTE; ACTA3; ACTL3
Cat.#:ACTG2-217HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACTG2 Protein, GST-tagged
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Cat.#:ACTG2-218HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACTG2 Protein, GST-tagged
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Cat.#:ACTG2-219HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACTG2 Protein, GST-tagged
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Cat.#:ACTG2-3096HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ACTG2, His-tagged
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Cat.#:ACTG2-6836HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTG2 protein, His & T7-tagged
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Cat.#:ACTG2-1243MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ACTG2 Protein
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Cat.#:Actg2-3095MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Actg2, His-tagged
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Cat.#:ACTG2-481RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACTG2 Protein
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Cat.#:ACTG2-6727CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACTG2
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Cat.#:ACTG2-9063HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ACTG2 293 Cell Lysate
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Involved Pathway

ACTG2 involved in several pathways and played different roles in them. We selected most pathways ACTG2 participated on our site, such as Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Vascular smooth muscle contraction
PRKG1; CYP4A12A; PLA2G12B; CALM1A; ACTA2; ACTG2; MAPK3; AGTR1B; PLA2G1B; CACNA1SA

Protein Function

ACTG2 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTG2 itself. We selected most functions ACTG2 had, and list some proteins which have the same functions with ACTG2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RIPK3; PRKCDA; CAMK2B; JAK2A; DDX50; FBXO18; ABCG2C; TWF2; HARS2; NLRC4
Function ATP-dependent RNA helicase activity
Related Protein DDX43; DHX33; DHX36; DDX53; DHX57; TMEM38A; DDX46; DHX30; DDX25; DDX21
Function helicase activity
Related Protein TDRD9; HELLS; CHD8; PIF1; MCM6L; HELZ2; DDX19; CHD7; GTF2F2A; ZRANB3
Function hydrolase activity
Related Protein ENOPH1; USP9; PTPRDB; ABHD2B; TMPRSS4A; ACY3.1; CAPN2B; CNOT6L; DUSP19B; MBTPS2
Function nucleic acid binding
Related Protein ZNFL2A; U2SURP; GIN1; ZNF503; ZKSCAN6; ZFP628; GRSF1; PTBP2B; ZNF143B; TDRD9
Function nucleotide binding
Related Protein RBM14B; HNRNPD; MYO7AA; POLD1; RBMS2; A1CF; EIF4A1B; Akap17b; PCXB; PABPC5

Interacting Protein

ACTG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTG2.
MLH1; UL36; 15-deoxy-delta(12,14; NS1; US11; ARRB2; VP24; RL1; GRB2; NS1

ACTG2 Related Articles

Wangler, MF; Gonzaga-Jauregui, C; et al. Heterozygous De Novo and Inherited Mutations in the Smooth Muscle Actin (ACTG2) Gene Underlie Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome. PLOS GENETICS 10:-(2014).
Lehtonen, HJ; Sipponen, T; et al. Segregation of a Missense Variant in Enteric Smooth Muscle Actin gamma-2 With Autosomal Dominant Familial Visceral Myopathy. GASTROENTEROLOGY 143:1482-+(2012).