ACTG2
-
Official Full Name
actin, gamma 2, smooth muscle, enteric
-
Overview
Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the;cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are;found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist;in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes;actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript;variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of;this gene is formed by removal of two N-terminal peptides. -
Synonyms
ACTG2; actin, gamma 2, smooth muscle, enteric; ACTA3, ACTL3; actin, gamma-enteric smooth muscle; ACTSG; alpha-actin 3; alpha-actin-3; gamma-2-actin; actin-like protein; smooth muscle gamma actin; smooth muscle gamma-actin; ACT; ACTE; ACTA3; ACTL3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ACTG2 Related Articles
ACTG2 involved in several pathways and played different roles in them. We selected most pathways ACTG2 participated on our site, such as Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vascular smooth muscle contraction | MAPK3;PLCB3;NPR2;PLCB2;PRKACBA;PRKCA;PRKCQ;PRKCBA;GNAS |
ACTG2 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTG2 itself. We selected most functions ACTG2 had, and list some proteins which have the same functions with ACTG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | HSPA7;SRPK1;PPIP5K2;TTLL6;DHX58;MYO6B;TWF2;MYO1F;PINK1 |
| ATP-dependent RNA helicase activity | DHX34;DDX42;BAT1;DDX47;DDX46;EIF4A2;DHX16;EIF4A3;DHX35 |
| helicase activity | MCM9;ATRX;SMARCAL1;DDX58;DDX11;HELZ;ACTG2;DHX37;PIF1 |
| hydrolase activity | DUSP23B;PPAPDC2;DESI1;METAP2;USP2A;HINT1;WRNIP1;C1rb;PCSK5B |
| nucleic acid binding | ZFP541;ZBTB46;ZFP536;ZFP523;ZNF281B;DDX19;RNASE2;TBK1;DPPA5A |
| nucleotide binding | ACSL1;RBM42;EIF4B;TNK2B;ENOX1;DXO;ARL3L2;NT5C1B;ABCG5 |
ACTG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTG2.
MLH1; UL36; 15-deoxy-delta(12,14; NS1; US11; ARRB2; VP24; RL1; GRB2; NS1
- Q&As
- Reviews
Q&As (18)
Ask a questionACTG2 has been found to have a critical role in HCC tumor metastasis.
Yes, ACTG2 expression can be regulated by various signaling pathways and transcription factors specific to smooth muscle cells.
ACTG2 inhibits cell growth in vitro.
While ACTG2 is primarily expressed in smooth muscle tissues, low levels of expression have also been detected in other tissues, suggesting potential additional functions.
The ACTG2 gene encodes the protein actin gamma-2, which is involved in muscle contraction and smooth muscle function.
Yes, mutations in the ACTG2 gene have been linked to a group of rare disorders called visceral myopathy, which affect the function of smooth muscles in the gastrointestinal tract.
ACTG2 can interact with various proteins involved in cytoskeletal organization and muscle contraction, such as myosin and other actin-binding proteins
ACTG2 is an essential component of the actin cytoskeleton in smooth muscle cells, providing structural support and facilitating the contraction of these muscles.
Yes, ACTG2 is regarded as a novel target for the treatment of HCC.
The discovery of ACTG2's role provides valuable insights for further understanding and potentially treating HCC.
ACTG2 is expressed in a fraction of small intestine neuroendocrine tumors (SI-NETs).
miR-145 positively regulates the expression of ACTG2.
Given its role in smooth muscle function, ACTG2 may hold therapeutic potential for conditions involving smooth muscle dysfunction, such as gastrointestinal motility disorders.
ACTG2 is primarily expressed in smooth muscle tissues, including the smooth muscle cells of the gastrointestinal tract, blood vessels, and uterus.
Symptoms of ACTG2-related visceral myopathy can include gastrointestinal dysmotility, constipation, difficulty swallowing, and other digestive issues.
The ACTG2 protein belongs to the actin family and has a globular structure composed of multiple subunits that form filaments.
Yes, targeting ACTG2 holds promise as a potential therapeutic approach for treating HCC.
The findings suggest potential therapeutic strategies for small intestine neuroendocrine tumors (SI-NETs) based on ACTG2 and its regulation by miR-145.
Customer Reviews (5)
Write a reviewOur experiments consistently demonstrate that the protein product effectively promotes cell proliferation and growth.
The purity of the protein is evident from the absence of any contaminants, ensuring reliable and accurate results.
We have used the protein product across multiple experiments, and its performance has remained consistent throughout.
The shipping process was expedited, ensuring timely delivery of the product to our laboratory.
The company's customer support team has been extremely helpful, promptly addressing any technical or scientific inquiries.
Ask a Question for All ACTG2 Products
Required fields are marked with *
My Review for All ACTG2 Products
Required fields are marked with *
