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ACTL7A

  • Official Full Name

    actin-like 7A

  • Overview

    The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.
  • Synonyms

    ACTL7A; actin-like 7A; actin-like protein 7A; actin-like 7-alpha; actin-like-7-alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACTL7A-9336H Recombinant Human ACTL7A, His-tagged E.coli His 1-280a.a.
Human ACTL7A-224H Recombinant Human ACTL7A Protein, GST-tagged Wheat Germ GST
Human ACTL7A-9059HCL Recombinant Human ACTL7A 293 Cell Lysate HEK293 N/A
Human ACTL7A-1169H Recombinant Human ACTL7A Protein (1-435 aa), His-SUMO-tagged E.coli His/SUMO 1-435 aa
Human ACTL7A-26590TH Recombinant Human ACTL7A N/A
Human ACTL7A-847HF Recombinant Full Length Human ACTL7A Protein, GST-tagged In Vitro Cell Free System GST 435 amino acids
Mouse ACTL7A-1246M Recombinant Mouse ACTL7A Protein Mammalian Cell His
Mouse ACTL7A-287M Recombinant Mouse ACTL7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ACTL7A-287M-B Recombinant Mouse ACTL7A Protein Pre-coupled Magnetic Beads HEK293
Rat ACTL7A-483R Recombinant Rat ACTL7A Protein Mammalian Cell His
Rat ACTL7A-139R Recombinant Rat ACTL7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ACTL7A-139R-B Recombinant Rat ACTL7A Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey ACTL7A-270C Recombinant Cynomolgus ACTL7A Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ACTL7A-20C Recombinant Cynomolgus Monkey ACTL7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ACTL7A-20C-B Recombinant Cynomolgus Monkey ACTL7A Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ACTL7A involved in several pathways and played different roles in them. We selected most pathways ACTL7A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTL7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ACTL7A has several biochemical functions, for example, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTL7A itself. We selected most functions ACTL7A had, and list some proteins which have the same functions with ACTL7A. You can find most of the proteins on our site.

Function Related Protein
protein bindingZNF394;RPLP1;LRRC8C;CENPT;CCDC41;SSU72;GSK3A;KIF20A;STK16
structural constituent of cytoskeletonKRT17;KRT6B;KRT71;TUBA2;ACTR2;GFAP;ACTG1;TUBA3C;TPM1

ACTL7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTL7A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTL7A.

TES; ENAH

  • Q&As
  • Reviews

Q&As (20)

Ask a question
How might the altered localization of ZPBP in Actl7a KO mice affect sperm-zona pellucida binding ability? 11/03/2022

The altered localization of ZPBP in Actl7a KO mice suggests a potential impact on sperm-zona pellucida binding ability.

How does Actl7a deficiency contribute to male infertility? 07/29/2022

Actl7a deficiency affects the localization of ZPBP, potentially impacting sperm-zona pellucida binding. It also leads to abnormalities in PLCZ1 localization and expression, resulting in reduced calcium oscillations in oocytes.

Where is ACTL7A found in the human body? 10/17/2021

ACTL7A is found in various tissues, including the brain, heart, liver, and skeletal muscle.

Can ACTL7A expression be regulated? 07/09/2021

Yes, ACTL7A expression can be regulated by various factors, including signaling pathways and transcription factors.

Does ACTL7A have any known paralogs or similar genes? 10/09/2020

Yes, ACTL7B is a paralog of ACTL7A, sharing sequence similarities and similar functions in chromatin remodeling.

What is the molecular function of ACTL7A? 08/26/2020

ACTL7A is involved in nucleosome assembly, histone binding, and ATP-dependent chromatin remodeling.

What do findings suggest about Actl7a and male infertility? 12/18/2019

It revearls the importance of ACTL7A in the complex processes involved in fertilization.

What condition is associated with Actl7a deficiency? 06/12/2019

Actl7a deficiency is linked to male infertility.

What is the consequence of the abnormal localization and expression of PLCZ1? 06/30/2018

The abnormal localization and expression of PLCZ1 resulted in reduced calcium oscillations in oocytes.

What are the known interactions of ACTL7A? 06/19/2018

ACTL7A interacts with other proteins involved in chromatin remodeling, such as SMARCA4 and SMARCA2.

Is there any research on the role of ACTL7A in neurodevelopmental disorders? 05/30/2018

Yes, studies have shown that ACTL7A mutations can contribute to neurodevelopmental disorders, and further research is being conducted in this area.

Is ACTL7A associated with cancer? 04/27/2018

There is currently no significant evidence linking ACTL7A to cancer development or progression.

 What was found regarding the localization of ZPBP in Actl7a homozygous KO male mice? 04/06/2018

The localization of ZPBP was found to be altered in the sperm of Actl7a homozygous KO male mice.

Can ACTL7A be a potential therapeutic target? 03/25/2018

While ACTL7A itself is not currently considered a therapeutic target, understanding its role in chromatin remodeling could have implications for future therapeutic interventions.

Are there any genetic disorders associated with ACTL7A mutations? 02/10/2018

Yes, mutations in ACTL7A have been linked to developmental disorders, including intellectual disability and autism spectrum disorder.

What is the relationship between ACTL7A and ZPBP? 09/21/2017

ACTL7A and ZPBP can form a complex that is potentially involved in acrosomal formation.

What will happen if ACTL7A undergoes a mutation? 05/27/2017

Mutations in the Actl7a gene have been reported to lead to male infertility

What is ACTL7A? 06/10/2016

ACTL7A plays a role in chromatin remodeling and gene transcription regulation.

What abnormalities were observed in the localization and expression of the PLCZ1 protein? 02/20/2016

Further studies revealed that the localization and expression of the PLCZ1 protein were abnormal in misshapen sperm.

Is ACTL7A involved in any specific biological processes? 01/02/2016

Yes, ACTL7A is involved in processes such as transcriptional regulation, DNA repair, and neuronal development.

Customer Reviews (5)

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Reviews
02/05/2020

    The company's customer support team is highly knowledgeable and responsive, readily available to address any technical or product-related queries.

    03/13/2019

      In our experiments, the protein product consistently exhibits robust and dose-dependent effects, leading to significant changes in the desired cellular responses.

      01/22/2019

        Each batch of the protein product shows minimal batch-to-batch variation, providing consistent results and reducing experimental variability.

        04/29/2018

          The protein product is manufactured using high-quality raw materials sourced from reputable suppliers, ensuring its purity and reliability.

          02/16/2017

            The protein product is carefully packaged using appropriate storage conditions, such as freeze-drying or cold chain shipping, to maintain its stability and integrity.

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