ACTL7A
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Official Full Name
actin-like 7A
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Overview
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. -
Synonyms
ACTL7A; actin-like 7A; actin-like protein 7A; actin-like 7-alpha; actin-like-7-alpha;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ACTL7A involved in several pathways and played different roles in them. We selected most pathways ACTL7A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTL7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ACTL7A has several biochemical functions, for example, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTL7A itself. We selected most functions ACTL7A had, and list some proteins which have the same functions with ACTL7A. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | ZNF394;RPLP1;LRRC8C;CENPT;CCDC41;SSU72;GSK3A;KIF20A;STK16 |
structural constituent of cytoskeleton | KRT17;KRT6B;KRT71;TUBA2;ACTR2;GFAP;ACTG1;TUBA3C;TPM1 |
ACTL7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTL7A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTL7A.
TES; ENAH
- Q&As
- Reviews
Q&As (20)
Ask a questionThe altered localization of ZPBP in Actl7a KO mice suggests a potential impact on sperm-zona pellucida binding ability.
Actl7a deficiency affects the localization of ZPBP, potentially impacting sperm-zona pellucida binding. It also leads to abnormalities in PLCZ1 localization and expression, resulting in reduced calcium oscillations in oocytes.
ACTL7A is found in various tissues, including the brain, heart, liver, and skeletal muscle.
Yes, ACTL7A expression can be regulated by various factors, including signaling pathways and transcription factors.
Yes, ACTL7B is a paralog of ACTL7A, sharing sequence similarities and similar functions in chromatin remodeling.
ACTL7A is involved in nucleosome assembly, histone binding, and ATP-dependent chromatin remodeling.
It revearls the importance of ACTL7A in the complex processes involved in fertilization.
Actl7a deficiency is linked to male infertility.
The abnormal localization and expression of PLCZ1 resulted in reduced calcium oscillations in oocytes.
ACTL7A interacts with other proteins involved in chromatin remodeling, such as SMARCA4 and SMARCA2.
Yes, studies have shown that ACTL7A mutations can contribute to neurodevelopmental disorders, and further research is being conducted in this area.
There is currently no significant evidence linking ACTL7A to cancer development or progression.
The localization of ZPBP was found to be altered in the sperm of Actl7a homozygous KO male mice.
While ACTL7A itself is not currently considered a therapeutic target, understanding its role in chromatin remodeling could have implications for future therapeutic interventions.
Yes, mutations in ACTL7A have been linked to developmental disorders, including intellectual disability and autism spectrum disorder.
ACTL7A and ZPBP can form a complex that is potentially involved in acrosomal formation.
Mutations in the Actl7a gene have been reported to lead to male infertility
ACTL7A plays a role in chromatin remodeling and gene transcription regulation.
Further studies revealed that the localization and expression of the PLCZ1 protein were abnormal in misshapen sperm.
Yes, ACTL7A is involved in processes such as transcriptional regulation, DNA repair, and neuronal development.
Customer Reviews (5)
Write a reviewThe company's customer support team is highly knowledgeable and responsive, readily available to address any technical or product-related queries.
In our experiments, the protein product consistently exhibits robust and dose-dependent effects, leading to significant changes in the desired cellular responses.
Each batch of the protein product shows minimal batch-to-batch variation, providing consistent results and reducing experimental variability.
The protein product is manufactured using high-quality raw materials sourced from reputable suppliers, ensuring its purity and reliability.
The protein product is carefully packaged using appropriate storage conditions, such as freeze-drying or cold chain shipping, to maintain its stability and integrity.
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