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Acvrl1

  • Official Full Name

    activin A receptor type II-like 1

  • Overview

    This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
  • Synonyms

    ACVRL1; activin A receptor type II-like 1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1; serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • Fc
  • His
  • hFc
  • Flag
  • GST
  • HIS
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACVRL1-644H Active Recombinant Human ACVRL1 protein, His-tagged HEK293 His Met 1-Gln 118
Human ACVRL1-534H Active Recombinant Human ACVRL1, Fc-tagged, Biotinylated Human Cell Fc
Human ACVRL1-9359H Recombinant Human ACVRL1, GST-tagged E.coli GST 142-503a.a.
Human ACVRL1-360H Recombinant Human ACVRL1 Protein, His-tagged Insect Cell His
Human ACVRL1-483H Recombinant Human Activin A Receptor Type II-Like 1 Mammalian cells N/A
Human ACVRL1-768H Active Recombinant Human ACVRL1 protein, hFc-tagged HEK293 hFc Met1-Gln118
Human ACVRL1-260H Recombinant Human ACVRL1 Protein, GST-tagged Wheat Germ GST
Human ACVRL1-238H Recombinant Human Activin A Receptor Type II-like 1, GST-tagged, Active Sf9 Insect Cell GST
Human ACVRL1-2629HCL Recombinant Human ACVRL1 cell lysate Human Cell N/A
Human ACVRL1-26214TH Recombinant Human ACVRL1, His-tagged HIS
Human ACVRL1-26593TH Recombinant Human ACVRL1 N/A
Human ACVRL1-1117H Recombinant Human ACVRL1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACVRL1-72H Recombinant Human ACVRL1 Protein, His-tagged E.coli N-His Ser238-Arg479
Human ACVRL1-P010H Recombinant Human ACVRL1, Fc-tagged therapeutic protein Fc
Human ACVRL1-1154H Recombinant Human ACVRL1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ACVRL1-0653H Recombinant Human ACVRL1 Protein (Met1-Ser392), C-His-tagged E.coli C-His Met1-Ser392
Human ACVRL1-1507HFL Recombinant Full Length Human ACVRL1 Protein, C-Flag-tagged Mammalian cells Flag
Human ACVRL1-090H Recombinant Human ACVRL1 Protein, His-tagged HEK293 His 503
Human ACVRL1-276H Recombinant Human ACVRL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ACVRL1-276H-B Recombinant Human ACVRL1 Protein Pre-coupled Magnetic Beads HEK293
Human ACVRL1-5332H Recombinant Human ACVRL1 Protein (Met1-Gln118), C-Fc tagged Mammalian cells C-Fc Met1-Gln118
Mouse Acvrl1-498M Recombinant Mouse Activin A Receptor, Type II-like 1, Fc-tagged Mammalian cells Fc
Mouse Acvrl1-2333M Active Recombinant Mouse Acvrl1 protein(Met1-Pro119), His&hFc-tagged HEK293 C-His&hFc Met1-Pro119
Mouse ACVRL1-3093MCL Recombinant Mouse ACVRL1 cell lysate Human Cell N/A
Mouse Acvrl1-530M Recombinant Mouse Acvrl1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Acvrl1-2M Recombinant Mouse Acvrl1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Acvrl1-2M-B Recombinant Mouse Acvrl1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Acvrl1-5599M Recombinant Mouse Acvrl1 Protein (Asp23-Pro119), C-His tagged Mammalian cells C-His Asp23-Pro119
Rat Acvrl1-245R Active Recombinant Rat Acvrl1 protein, His&hFc-tagged HEK293 His&hFc Met1-Ala118
Rat ACVRL1-496R Recombinant Rat ACVRL1 Protein Mammalian Cell His
Rat ACVRL1-3001RCL Recombinant Rat ACVRL1 cell lysate Human Cell N/A
Rat ACVRL1-152R-B Recombinant Rat ACVRL1 Protein Pre-coupled Magnetic Beads HEK293
Rat ACVRL1-152R Recombinant Rat ACVRL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canine ACVRL1-318C Active Recombinant Canine ACVRL1 protein, hFc-tagged HEK293 hFc Met1-Gln119
Canine ACVRL1-994CCL Recombinant Canine ACVRL1 cell lysate Human Cell N/A
Cynomolgus ACVRL1-1186C Active Recombinant Cynomolgus ACVRL1 protein(Met1-Gln118), His-tagged HEK293 C-His Met1-Gln118
Cynomolgus Monkey ACVRL1-8813C Recombinant Cynomolgus ACVRL1, Fc tagged Human Cell His
Cynomolgus Monkey ACVRL1-1191CCL Recombinant Cynomolgus ACVRL1 cell lysate Human Cell N/A
Homo sapiens (Human) RFL-27120HF Recombinant Full Length Human Serine/Threonine-Protein Kinase Receptor R3(Acvrl1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-503)
Rattus norvegicus (Rat) RFL-22172RF Recombinant Full Length Rat Serine/Threonine-Protein Kinase Receptor R3(Acvrl1) Protein, His-Tagged E.coli expression system His Full Length (21-504)
Zebrafish ACVRL1-9455Z Recombinant Zebrafish ACVRL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Acvrl1 Related Research Area

Acvrl1 involved in several pathways and played different roles in them. We selected most pathways Acvrl1 participated on our site, such as ALK1 pathway, ALK1 signaling events, Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Acvrl1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ALK1 pathwayACVRL1;FKBP1A
ALK1 signaling eventsCSNK2B;FKBP1A;GDF2;ACVRL1
Id Signaling PathwayMYF6;KDR;IFI16;PAX2;ACVRL1;TCF12;TCF3B;MYOD1;ELK3
TGF-beta Receptor Signaling PathwaySTK11IP;NFYBB;MEF2AA;DAB2;ENG;STRAP;SNIP1;VDRB;HOXD9A

Acvrl1 has several biochemical functions, for example, ATP binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Acvrl1 itself. We selected most functions Acvrl1 had, and list some proteins which have the same functions with Acvrl1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingAASDH;MET;CAMK2D1;PIP5K1A;HSP104;RIPK2;CSF1R;CCT4;UBE2T
SMAD bindingEID2;BMPR1A;SKOR1B;SKOR1A;TOB1;ACVRL1;FOXH1;PRDM16;ACVR1
activin bindingSMURF1;TGFBR3;ACVRL1;ENG;FKBP1A;FSTL3;FST;ACVR1;ACVR2B
activin receptor activity, type IACVR1C;ACVR1B;ACVRL1
contributes_to activin receptor activity, type IACVRL1;ACVR1
metal ion bindingCYP2X8;ZBTB2;RCVRNA;SMYD2;ITGA4;ZMYND12;AOX3;RC3H1;NAIP6
protein bindingVRK2;FAM110C;CENPO;CYBRD1;LDOC1;MAGEA4;PARD6B;RTF1;COQ7
protein kinase bindingRICTOR;TRAF3;CAMK2N2;FBXO7;CD4;PPP1R12C;LATS1;LIMS1;DCX
protein serine/threonine kinase activityC9orf96;TNNI3K;LIMK1;TSSK6;NEK12;CDK15;DMPK;STK33;MAP3K14
receptor signaling protein serine/threonine kinase activityBMPR1AA;ACVR1;ACVRL1;OXSR1A;BMPR1AB;ACVR2AA;ACVR1C;TGFBR1B;SLKA
transforming growth factor beta bindingLTBP1;HYAL2;CD109;LTBP4;TGFBR2;ITGAV;TGFBR1;TGFBR3;ENG
contributes_to transforming growth factor beta receptor activity, type I
transforming growth factor beta-activated receptor activityACVRL1;BMPR2A;TGFBR3;TGFBR2;ENG;LTBP1;BMPR2B;TGFBR1
transmembrane receptor protein serine/threonine kinase activityBMPR1AA;BMPR1BB;TGFBR1B;ACVR2AA;BMPR1B;ACVRL1;BMPR2A;TGFBR2;BMPR1BA

Acvrl1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Acvrl1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Acvrl1.

ITGA5

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