adam9
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  • Official Full Name
  • ADAM metallopeptidase domain 9
  • Background
  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
  • Synonyms
  • ADAM9; ADAM metallopeptidase domain 9; MCMP; MDC9; CORD9; Mltng; disintegrin and metalloproteinase domain-containing protein 9; cone rod dystrophy 9; myeloma cell metalloproteinase; cellular disintegrin-related protein; ADAM metallopeptidase domain 9 (meltrin gamma); metalloprotease/disintegrin/cysteine-rich protein 9;
Cat.#:ADAM9-311HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ADAM9 Protein, His-tagged
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Cat.#:ADAM9-293HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAM9 Protein, GST-tagged
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Cat.#:ADAM9-3005HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAM9, His-tagged
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Cat.#:Adam9-830MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Adam9 Protein, His-tagged
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Cat.#:ADAM9-3047CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADAM9
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Cat.#:ADAM9-1386ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ADAM9
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Cat.#:ADAM9-1750MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ADAM9 cell lysate
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Involved Pathway

ADAM9 involved in several pathways and played different roles in them. We selected most pathways ADAM9 participated on our site, such as Collagen degradation, Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Collagen degradation
CTSLL; MMP20; CTS7; LOC100686744; CTSK; COL9A3; COL17A1; TLDC2; COL19A1; MMP13
Degradation of the extracellular matrix
COL25A1; ELANE; MMP20; MMP15; BMP1; TLDC2; MMP24; BSG; MMP12; CTSG
Extracellular matrix organization
NID1; ELANE; LOX; SPARC; ADAMTS1; EFEMP2; TPSAB1; ADAM15; FBLN2; ADAMTS4

Protein Function

ADAM9 has several biochemical functions, for example, SH3 domain binding, collagen binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM9 itself. We selected most functions ADAM9 had, and list some proteins which have the same functions with ADAM9. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein RAD9; BCAR1; CBL; REPS1; VASP; SH3BP5LA; SH3BP5; SH3BGRL2; HCLS1; MYPN
Function collagen binding
Related Protein MMP9; GP5; SERPINH1B; SPARC; CD44; ASPN; VWF; CCBE1; ADAM9; SERPINH2
Function integrin binding
Related Protein ITGA6; S1PR2; FBLN1; AMICA1; FAP; VWF; ITGB6; WISP2; IGF1; ITGA3
Function laminin binding
Related Protein TINAGL1; AGRN; LYPD5; ACHE; ITGA9; PLEKHA2; ADAM9; THBS1; CTSS; NCL
Function metalloendopeptidase activity
Related Protein SPG7; ADAM8; ADAM23; C6AST4; MMP13; FAP; MME; ADAMTSL5; ADAMTS3; NRD1B
Function metallopeptidase activity
Related Protein ADAM12; AGBL4; C6AST3; MMP23B; YME1L1; ADAM21; ADAMTS5; ERMP1; LNPEP; PAPPA
Function protein binding
Related Protein ANK1; GIT1; AIPL1; RAET1D; RBX1; P4HA1; TWIST1; FAM111A; PAK2; RBL2
Function protein kinase C binding
Related Protein PKP2; SDPRA; HDAC7A; FEZ1; ADAM9; AKT1; TWF2; GLRX3; HDAC5; TDG
Function zinc ion binding
Related Protein TRIM65; RNF5; LHX1A; TRIM15; CPZ; Alb; ACE; KCMF1; CXXC1A; RYBP

Interacting Protein

ADAM9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM9 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM9.
MAD2L2; SH3GL2; PACSIN3; KIF2C

ADAM9 Related Articles

Kim, JM; Jeung, HC; et al. The Effect of Disintegrin-Metalloproteinase ADAM9 in Gastric Cancer Progression. MOLECULAR CANCER THERAPEUTICS 13:3074-3085(2014).
Webber, J; Stone, TC; et al. Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscan(TM)) Platform*. MOLECULAR & CELLULAR PROTEOMICS 13:1050-1064(2014).