adarb1
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  • Official Full Name
  • adenosine deaminase, RNA-specific, B1
  • Background
  • This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.
  • Synonyms
  • ADARB1; adenosine deaminase, RNA-specific, B1; adenosine deaminase, RNA specific, B1 (homolog of rat RED1); double-stranded RNA-specific editase 1; ADAR2; ADAR2a; ADAR2a L1; ADAR2a L2; ADAR2a L3; ADAR2b; ADAR2c; ADAR2d; ADAR2g; DRABA2; DRADA2; hRED1; RED1; RED1 homolog (rat); ADARB 1; 1700057H01Rik; Adenosine deaminase, RNA specific, 2; Adenosine deaminase, RNA specific, B1 (RED1 homolog rat); Adenosine deaminase, RNA specific, B1; AW124433; AW558573; BB220382; D10Bwg0447e; Double stranded RNA specific editase 1; dsRNA adenosine deaminase; EC 3.5.-.-; Human dsRNA adenosine deaminase DRADA2; Human dsRNA adenosine deaminase DRADA2b, EC 3.5; OTTHUMP00000115341; OTTHUMP00000115342; RED 1; RNA editase; RNA editase 1; RNA editing deaminase 1; RNA editing enzyme 1; RNA editing enzyme 1, rat, homolog of; RNA specific adenosine deaminase B1; RED1 homolog; OTTHUMP00000115339; OTTHUMP00000115340; OTTHUMP00000174981; OTTHUMP00000214128; RNA-editing enzyme 1; RNA-editing deaminase 1; dsRNA ad
Cat.#:ADARB1-1147HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADARB1 Protein, MYC/DDK-tagged
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Cat.#:ADARB1-314HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADARB1 Protein, GST-tagged
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Cat.#:ADARB1-315HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADARB1 Protein, GST-tagged
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Cat.#:ADARB1-511RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADARB1 Protein
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Cat.#:ADARB1-3775CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADARB1
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Cat.#:ADARB1-5813CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADARB1
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Cat.#:ADARB1-28HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ADARB1 cell lysate
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Involved Pathway

ADARB1 involved in several pathways and played different roles in them. We selected most pathways ADARB1 participated on our site, such as C6 deamination of adenosine, Formation of editosomes by ADAR proteins, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADARB1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
C6 deamination of adenosine
ADARB1A; ADAR; ADARB1
Formation of editosomes by ADAR proteins
ADARB1; ADAR; ADARB1A
Gene Expression
DARS; THOC4; TNPO1; EIF2S3; PTRF; SNAPC4; EIF4B; ZNF12; ZNF215; RPP30
mRNA Editing
ADARB1; A1CF; APOBEC1; ADARB1A
mRNA Editing: A to I Conversion
ADARB1A; ADARB1

Protein Function

ADARB1 has several biochemical functions, for example, RNA binding, adenosine deaminase activity, double-stranded RNA adenosine deaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADARB1 itself. We selected most functions ADARB1 had, and list some proteins which have the same functions with ADARB1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein D19BWG1357E; HENMT1; RALY; UMPS; ACO1; PKZ; SRRM4; EXOSC6; RPL18A; SRSF1B
Function adenosine deaminase activity
Related Protein ADARB2; ADAD1; CECR1; ADAL; ADAD2; CECR1A; ADA; ADARB1; ADARB1A
Function double-stranded RNA adenosine deaminase activity
Related Protein PKZ; ADAR; ADARB1; ZBP1
Function double-stranded RNA binding
Related Protein DROSHA; OASL; HSP90AB1; OAS1A; EIF2C3; OAS3; SUPV3L1; OASL2; RFTN1; OAS1B
Function mRNA binding
Related Protein RBMY1A1; HSP26; ITM2B; NXF2; RPL7; EIF4A1; ADARB1; KIAA0020; LIN28A; THOC2
Function metal ion binding
Related Protein TRIM35-19; ZNF705B; MAT2A; ZNF518A; ZFP36; PRSS1; DYTN; ZFP641; RPS27.1; ZNF652
Function poly(A) RNA binding
Related Protein SNRPG; SR140; UBE2I; CDC42EP4; RBM26; RAVER2; TBRG4; CCDC59; EIF1B; ZC3H10
Function protein binding
Related Protein ZNF34; TAGLN2; EDARADD; ZHX2; INTS3; RQCD1; LPP; GEMIN6; PGAP2; KLHL35

Interacting Protein

ADARB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADARB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADARB1.
PIN1; WWP2; HNRNPA1; Rpl35; Ufl1

ADARB1 Related Articles

Allegra, D; Bilan, V; et al. Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia. LEUKEMIA 28:98-107(2014).
Mertens, D; Allegra, D; et al. ADARB1 Is Involved In a Reduced Maturation Of The miR15a/Mir-16-1 Family In Chronic Lymphocytic Leukemia. BLOOD 122:-(2013).