adat1
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  • Official Full Name
  • adenosine deaminase, tRNA-specific 1
  • Background
  • This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described.
  • Synonyms
  • ADAT1; adenosine deaminase, tRNA-specific 1; tRNA-specific adenosine deaminase 1; adenosine deaminase acting on tRNA; tRNA-specific adenosine-37 deaminase; HADAT1
Cat.#:ADAT1-1143HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAT1 Protein, GST/His-tagged
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Cat.#:ADAT1-28HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAT1, T7-tagged
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Cat.#:ADAT1-3157HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Homo sapiens ADAT1
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Cat.#:ADAT1-317HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAT1 Protein, GST-tagged
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Cat.#:ADAT1-1333MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADAT1 Protein
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Cat.#:ADAT1-278CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ADAT1 Protein, His-tagged
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Cat.#:ADAT1-237RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ADAT1 Protein, His-tagged
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Cat.#:ADAT1-2008CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADAT1
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Cat.#:ADAT1-5268ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ADAT1
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Cat.#:ADAT1-9024HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ADAT1 293 Cell Lysate
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Involved Pathway

ADAT1 involved in several pathways and played different roles in them. We selected most pathways ADAT1 participated on our site, such as Gene Expression, tRNA modification in the nucleus and cytosol, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
COX14; PDCD7; HNRNPH1; TNPO1; AARS; ZNF143B; ZNF582; TRIM33; EFCAB11; EEF2
tRNA modification in the nucleus and cytosol
TPRKB; CCDC76; ADAT1; METTL1; LBH; LAGE3; TRMT1; NSUN2; TYW3; PUS7
tRNA processing
RPP40; MANEA; TSEN2; CCDC76; ELAC2; TRMT44; TSEN54; XPOT; C14orf166; TYW5

Protein Function

ADAT1 has several biochemical functions, for example, RNA binding, metal ion binding, tRNA-specific adenosine deaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAT1 itself. We selected most functions ADAT1 had, and list some proteins which have the same functions with ADAT1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein ZFML; HNRPK; EIF4EA; RNMTL1B; EXOSC9; HNRNPA0; WT1; UPF1; SYNCRIP; TUT1
Function metal ion binding
Related Protein PPM1NB; FAHD2A; PRDM6; CACNA2D3; TESK1; PPP6C; HDAC5; PHOSPHO1; SMAD5; PDE4C
Function tRNA-specific adenosine deaminase activity
Related Protein ADAT1

ADAT1 Related Articles

Luo, M; Schramn, VL; et al. Transition state structure of E. coli tRNA-specific adenosine deaminase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130:2649-2655(2008).
Kim, J; Malashkevich, V; et al. Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. BIOCHEMISTRY 45:6407-6416(2006).