add1
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  • Official Full Name
  • adducin 1 (alpha)
  • Background
  • Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
  • Synonyms
  • ADD1; adducin 1 (alpha); alpha-adducin; erythrocyte adducin alpha subunit; ADDA; MGC3339; MGC44427
Cat.#:ADD1-491HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADD1 Protein, His-tagged
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Cat.#:Add1-492MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Add1 Protein, His-tagged
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Cat.#:ADD1-3338HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ADD1, His-tagged
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Cat.#:ADD1-336HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADD1 Protein, GST-tagged
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Cat.#:ADD1-1350MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADD1 Protein
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Cat.#:ADD1-522RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADD1 Protein
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Cat.#:ADD1-242RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ADD1 Protein, His-tagged
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Cat.#:ADD1-3563CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADD1
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Cat.#:ADD1-4917ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ADD1
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Cat.#:ADD1-9017HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ADD1 293 Cell Lysate
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Involved Pathway

ADD1 involved in several pathways and played different roles in them. We selected most pathways ADD1 participated on our site, such as Apoptosis, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
AKT1; DFFB; IL3; IL1RAP; STK24A; CASP8L1; BCL2; GAS2; IKBKB; PRKAR2AA
Apoptotic cleavage of cellular proteins
DSP; CASP6L2; GAS2; DSG3; DSG1; PLECA; BCAP31; ADD1; STK24; STK26
Apoptotic execution phase
H1F0; DSG3; DNM1L; VIML; STK24A; HIST1H1A; CASP6L2; DSG1; GAS2; HMGB2
Caspase-mediated cleavage of cytoskeletal proteins
DBNLA; PLECA; VIML; SPNA2; PLEC; DBNLB; CASP6L1; CASP6L2; DBNL; GAS2
IRE1alpha activates chaperones
KDELR3; CTDSP2; WIPI1; ASNA1; DDX11; SERP1; YIF1A; DNAJB9; HDGF; FKBP14
Metabolism of proteins
TBCC; CKAP4; MPDU1; GRPEL2; CMA1; NSMCE2; STT3A; ST3GAL3A; CTAGE5; FBXW2
Miscellaneous transport and binding events
EPB49; ANKHA; ADD3; DMTN; MMGT1; ADD1; NIPA1; ADD3B; AZGP1; ADD2
Programmed Cell Death
DBNLA; STK24B; DAPK1; BMX; BAXB; HMGB2A; STK24; SATB1; DIABLO; STK24A

Protein Function

ADD1 has several biochemical functions, for example, actin binding, actin filament binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADD1 itself. We selected most functions ADD1 had, and list some proteins which have the same functions with ADD1. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein WIPF2B; CAPGB; PAWR; IPP; KCNMA1; NCALD; MYO10; MYOT; MSN; MYO1G
Function actin filament binding
Related Protein TULP1; USH1C; AASS; FLNC; DBNL; FSCN1A; ADD1; HIST1H2AH; MYO3A; SHROOM4
Function calmodulin binding
Related Protein CAMKK2; CALD1B; MAPKAPK5; PPP3CA; CAMSAP1L1; KCNH5; CAMK2B1; MYO9B; MARCKSL1B; PLCB1
Function poly(A) RNA binding
Related Protein ATXN2; EIF4A2; BTF3; DDX46; PURG; ZAK; MYH9; MRPL21; BZW1; PURB
Function protein binding
Related Protein MYF5; PPP1R13L; EDEM1; KLHL3; NEUROG3; EIF4EBP2; KDM5A; HDGFRP2; ARL3; CCDC64
Function protein heterodimerization activity
Related Protein YWHAH; POLA2; BCL2A1; MYF5; ATF3; H2-AB1; SIM2; RRAGA; POLA1; CREB3L3
Function protein homodimerization activity
Related Protein BAXA; HMOX1; TFAP2B; AXIN1; VOX; PDGFRA; CADM1; CPNE1; CREB3L3; ADH5
Function spectrin binding
Related Protein GNB1; GBP1; MYO7A; MYO10; ANK1; USH1G; SPTAN1; EPB41; EPB49; CAMSAP1L1
Function structural molecule activity
Related Protein SPRR2A; ANK1; KRTAP11-1; KRT25; MAPK8IP2; KRT7; NEFMA; KRT12; NGS; VCL
Function transcription factor binding
Related Protein AHR; HES6; MAFB; ARID5A; NIF3L1; UBN1; PIK3R1; REST; AGTR2; CEBPB

Interacting Protein

ADD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADD1.
RFX1; saicar; PKM; TK1; CSNK2B; ppdK; icmF1; mfd; q8czf9_yerpe; chbG; MAP1LC3B; GEMIN7; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; DST; ssdna_dtdg; TPM3