ADNP
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Official Full Name
activity-dependent neuroprotector homeobox
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Overview
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. -
Synonyms
ADNP; activity-dependent neuroprotector homeobox; activity dependent neuroprotector; activity-dependent neuroprotector homeobox protein; ADNP homeobox 1; ADNP1; KIAA0784; Activity dependent neuroprotective protein; OTTHUMP00000031275; OTTHUMP00000031276; OTTHUMP00000165329; OTTHUMP00000229415; activity-dependent neuroprotective protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ADNP-365H | Recombinant Human ADNP Protein, GST-tagged | Wheat Germ | GST | ||
Human | ADNP-9008HCL | Recombinant Human ADNP 293 Cell Lysate | HEK293 | N/A | ||
Human | ADNP-0118H | Recombinant Human ADNP Protein (Ala528-Thr782), N-GST-tagged | E.coli | N-GST | Ala528-Thr782 | |
Human | ADNP-1701H | Recombinant Human ADNP protein, His & GST-tagged | E.coli | His/GST | Ala528~Thr782 (Accession # Q9H2P0) | |
Rhesus Macaque | ADNP-252R | Recombinant Rhesus monkey ADNP Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | ADNP-80R-B | Recombinant Rhesus Macaque ADNP Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | ADNP-80R | Recombinant Rhesus Macaque ADNP Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
- ADNP Related Articles
- ADNP Related Research Area
ADNP involved in several pathways and played different roles in them. We selected most pathways ADNP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADNP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ADNP has several biochemical functions, for example, DNA binding, beta-tubulin binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADNP itself. We selected most functions ADNP had, and list some proteins which have the same functions with ADNP. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | MXTX1;TMPOA;NKX2.2B;RORA;PRM2;PUF60B;ZNF10;PCBP3;HOXB1 |
beta-tubulin binding | SPAST;GABARAP;TBCD;SNCA;RGS2;RACGAP1;NDEL1;SLC6A2;VAPB |
chromatin binding | EGFR;PHF13;MPO;RAG2;ERCC6;YAP1;EGR2;LDB1;PAF1 |
copper ion binding | CP;P2RX4;SERPINB1A;TYRP1;POLR1B;PRNP;DBH;APOA4;HEPH |
peptide binding | LNPEP;CRHBP;NPFFR1L2;AVPR2L;FURIN;FNTB;AVPR1A;GPR37;ERAP2 |
protein binding | HSPA14;KRTAP13-3;VARS;DKK1;HSPA4L;MED23;RFESD;PIGS;DHX16 |
ADNP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADNP here. Most of them are supplied by our site. Hope this information will be useful for your research of ADNP.
CBX5; HDAC1; CBX1; CBX3; PLCG1; GAMMAHV.ORF37; CDC27; hemC; MAP1LC3B; AIM2; MYC; cona_canen; DBP; KPNA1; DYNLL1
- Q&As
- Reviews
Q&As (13)
Ask a questionCurrently, ADNP mutations are not routinely used as a diagnostic tool for ASD. However, further research may elucidate ADNP's involvement in autism and its potential for diagnostic purposes.
Research suggests that ADNP mutations can disrupt normal brain development, leading to various neurological disorders. ADNP is involved in regulating the expression of genes that are crucial for the development and function of neurons, including genes that control synaptic plasticity, dendrite branching, and axon extension.
ADNP has been proposed as a potential therapeutic target for certain types of cancer. However, more research is needed to elucidate ADNP's role in cancer and its potential as a therapeutic target.
Currently, there are no known clinical trials specifically targeting ADNP-associated disorders. However, there are clinical trials for other disorders that may be relevant for individuals with ADNP mutations, such as ASD and intellectual disability.
There are currently no drugs that specifically target ADNP. However, some drugs that modulate ADNP activity indirectly, such as valproic acid and FK506, have been investigated for their potential therapeutic effects in various neurological disorders.
ADNP (activity-dependent neuroprotective protein) is a neuroprotective protein that plays a critical role in brain development and function. It is involved in various biological processes, such as DNA repair, transcriptional regulation, and cell proliferation.
One of the main challenges in researching ADNP is its complex role in various biological processes, including epigenetic regulation, chromatin remodeling, and transcriptional regulation. This complexity makes it difficult to determine the specific mechanisms underlying ADNP's effects on neuronal development and function.
ADNP is one of several genes that have been identified as ASD risk genes. Other ASD risk genes include SHANK3, SYNGAP1, and CHD8. These genes are involved in various aspects of brain development and function, such as synapse formation and maintenance, neuronal signaling, and chromatin regulation.
One of the main challenges in developing treatments for ADNP-associated disorders is the complexity of ADNP's role in neuronal development and function. ADNP is involved in many different biological processes, including chromatin remodeling, transcriptional regulation, and epigenetic modification. Developing targeted therapies that modulate ADNP activity without disrupting these other biological processes is challenging.
One of the main challenges in developing ADNP-based therapies is understanding the complex nature of ADNP's involvement in various biological processes, as well as its functional role in different disease states. Additionally, delivering ADNP-based therapies to specific target tissues or cells may be challenging.
ADNP has shown potential as a therapeutic target for a range of neurodegenerative diseases, including AD and Parkinson's disease. However, further research is needed before ADNP-based treatments can become a clinical reality.
Studying ADNP's involvement in brain development and function can provide insights into the complex molecular mechanisms that underlie these processes. Understanding the role of ADNP in neuronal development and synaptic plasticity could pave the way for new treatments for neurological disorders such as autism and Alzheimer's disease. Additionally, ADNP research may contribute to our understanding of the genetic and environmental factors that shape brain development and function.
ADNP mutations can be inherited in an autosomal dominant or sporadic pattern. In autosomal dominant inheritance, a single copy of the mutated ADNP gene from one parent is sufficient to cause the disorder. In sporadic cases, the mutation occurs randomly and is not inherited from either parent.
Customer Reviews (4)
Write a reviewI am grateful for the access to such exceptional resources and look forward to continued success in our research endeavors.
Its purity and stability characteristics are exceptional, making it highly suitable for our experimental needs.
the manufacturer's technical support team has been extremely helpful in providing solutions to any issues we encounter during our experiments.
Based on my research and prior experience, I can confidently state that the protein we are working with is of extremely high quality.
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