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ADPGK

  • Official Full Name

    ADP-dependent glucokinase

  • Overview

    ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 (PubMed 14975750)).
  • Synonyms

    ADPGK; ADP-dependent glucokinase; ADP GK; DKFZp434B195; rbBP-35; ATP-dependent glucokinase; ADP-GK; 2610017G09Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Pyrococcus furiosus
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Pyrococcus Furiosus
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADPGK-33H Recombinant Human ADPGK protein, GST-tagged Wheat Germ GST
Human ADPGK-985H Recombinant Human ADPGK protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ADPGK-34H Recombinant Human ADPGK protein, GST-tagged E.coli GST
Human ADPGK-9004HCL Recombinant Human ADPGK 293 Cell Lysate HEK293 N/A
Human ADPGK-719HF Recombinant Full Length Human ADPGK Protein, GST-tagged In Vitro Cell Free System GST 497 amino acids
Human ADPGK-3770H Recombinant Human ADPGK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse ADPGK-1374M Recombinant Mouse ADPGK Protein Mammalian Cell His
Mouse ADPGK-358M Recombinant Mouse ADPGK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Adpgk-1543M Recombinant Mouse Adpgk Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ADPGK-358M-B Recombinant Mouse ADPGK Protein Pre-coupled Magnetic Beads HEK293
Bovine ADPGK-3204B Recombinant Bovine ADPGK, His-tagged E.Coli or Yeast His 497
Pyrococcus furiosus ADPGK-45 Active Native ADP-specific glucokinase Pyrococcus Furiosus N/A
Zebrafish ADPGK-4923Z Recombinant Zebrafish ADPGK Mammalian Cell His
Chicken ADPGK-5548C Recombinant Chicken ADPGK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADPGK Related Articles

ADPGK involved in several pathways and played different roles in them. We selected most pathways ADPGK participated on our site, such as Glycolysis / Gluconeogenesis, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADPGK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisACSS1;ADH2-1;PCK2;AKR1A1B;ALDOAB;MINPP1A;ALDH9A1A.1;PGAM1B;TPI1A
Metabolic pathwaysURAD;MTHFD2L;INPP5K;SCLY;ALDH2.1;ST8SIA1;ASMT;CYP7A1;ITPK1
Carbon metabolismACSS1;PKMB;GLDC;GLUD1A;ADPGK;FBP1A;PKMA;PKM;GPT2

ADPGK has several biochemical functions, for example, ADP-specific glucokinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADPGK itself. We selected most functions ADPGK had, and list some proteins which have the same functions with ADPGK. You can find most of the proteins on our site.

Function Related Protein
ADP-specific glucokinase activity
metal ion bindingZNF480;SCRT1;PDLIM5B;ZNF426;ZFP710;HIC2;ADCY7;FTR54;NRAP

ADPGK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADPGK here. Most of them are supplied by our site. Hope this information will be useful for your research of ADPGK.

TCAP; GDF9; TADA3; rsmH; UBQLN4

Kumar, PS; Umar, YNK; et al. Comparative Structural and Functional Analysis of Staphylococcus aureus Glucokinase with other Bacterial Glucokinases. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES 76:430-436(2014).
Castro-Fernandez, V; Bravo-Moraga, F; et al. Bifunctional ADP-dependent phosphofructokinase/ glucokinase activity in the order Methanococcales biochemical characterization of the mesophilic enzyme from Methanococcus maripaludis. FEBS JOURNAL 281:2017-2029(2014).
  • Q&As
  • Reviews

Q&As (13)

Ask a question
Can mutations in the ADPGK gene cause disease? 01/30/2023

Currently, there is limited evidence to suggest that mutations in the ADPGK gene itself directly cause disease. However, some studies have identified single nucleotide polymorphisms (SNPs) in ADPGK that may be associated with increased risk of certain disease states, such as Alzheimer's disease and type 2 diabetes.

What are the challenges in studying Adpgk? 07/06/2022

One of the main challenges in studying Adpgk is the lack of knowledge about its cellular functions and regulatory mechanisms. Additionally, because Adpgk is a relatively understudied gene, there is limited information available about its interactions with other proteins and cellular processes. More research is needed to fully understand the role of Adpgk in health and disease.

How is Adpgk studied in the laboratory? 06/24/2021

Researchers can study Adpgk in the laboratory using a variety of techniques, such as enzyme assays, western blotting, and immunohistochemistry. They may also use genetic and molecular biology tools to manipulate Adpgk expression or function in cells or animal models.

Is there any ongoing research on Adpgk? 12/13/2019

Yes, there is ongoing research on Adpgk in a variety of fields, including metabolism, immunology, and drug development. Scientists are working to better understand the function of Adpgk in these contexts and explore its potential as a therapeutic target.

Can Adpgk be used as a potential drug target for metabolic disorders? 10/11/2019

There is growing interest in Adpgk as a potential drug target for metabolic disorders. Some studies have suggested that modulation of Adpgk activity could help regulate glucose metabolism, improve insulin sensitivity, and reduce the risk of metabolic diseases such as obesity and diabetes. However, further research is needed to fully explore the therapeutic potential of Adpgk in this context.

Where is Adpgk expressed in the body? 04/16/2019

Adpgk is expressed in a variety of tissues throughout the body, with highest expression levels observed in the liver, muscle, and brain. It is also present in adipose tissue, kidney, heart, and pancreas, although to a lesser extent. The widespread expression of Adpgk suggests that it plays a role in multiple physiological processes and that dysregulation of its expression or activity could contribute to the development of various diseases.

How is Adpgk regulated? 01/25/2019

Adpgk expression and activity are regulated by a variety of factors, including hormonal signals, nutrient availability, and oxidative stress. Insulin and glucagon are two key hormones that regulate Adpgk expression in response to changes in blood glucose levels. Nutrient availability also plays a role in Adpgk regulation, with high glucose levels leading to increased Adpgk expression. Furthermore, Adpgk activity can be modulated by post-translational modifications such as phosphorylation, acetylation, and ubiquitination. Finally, oxidative stress has been shown to downregulate Adpgk expression, possibly through the activation of stress-responsive pathways such as NF-κB.

Is Adpgk a potential target for drug development? 03/01/2018

Yes, Adpgk has been identified as a potential target for drug development in the treatment of metabolic disorders such as diabetes. Researchers are exploring the use of Adpgk activators or inhibitors to modulate glucose metabolism and improve glycemic control in patients with these conditions. However, further research is needed to determine the safety and efficacy of these approaches.

How is Adpgk studied in the laboratory? 02/09/2018

Adpgk can be studied in the laboratory using a variety of techniques, including molecular biology, biochemistry, and cell biology approaches. These may involve cloning and expressing Adpgk in bacterial or eukaryotic cells, purifying the protein to determine its structure and enzymatic activity, or using gene knockdown or overexpression techniques to investigate its function in cells or animal models. In addition, high-throughput screening methods such as chemical compound libraries can be used to identify small molecules that modulate Adpgk activity or expression.

What are the functions of Adpgk? 06/28/2017

Adpgk is involved in several cellular processes, including glucose metabolism, glycolysis, and glycogen synthesis. Its primary function is to catalyze the conversion of ADP-glucose (ADPG) to glucose-1-phosphate (G1P), which is an important step in glycogen synthesis. It also plays a role in regulating glucose metabolism and insulin signaling by modulating the levels of ADPG and G1P. In addition, Adpgk has been implicated in other processes such as DNA repair, lipid metabolism, and autophagy.

Are there any medical conditions associated with Adpgk mutations? 04/19/2017

Yes, mutations in the Adpgk gene have been linked to several medical conditions, including glycogen storage disease type 0 and type 13. These conditions are characterized by a deficiency in Adpgk activity, which impairs the body's ability to synthesize glycogen and regulate blood glucose levels. Symptoms of these conditions may include hypoglycemia, muscle weakness, and fatigue.

Can Adpgk be used as a biomarker for disease? 06/30/2016

There is some evidence to suggest that Adpgk levels may be altered in certain disease states, such as diabetes and liver disease. However, more research is needed to determine whether Adpgk could be used as a reliable biomarker for these conditions.

Are there any drugs that target Adpgk? 03/16/2016

Currently, there are no drugs that specifically target Adpgk. However, some compounds have been identified that can modulate Adpgk activity or expression indirectly. For example, some studies have found that certain bioactive compounds, such as berberine and quercetin, can induce Adpgk expression in cells and potentially have therapeutic benefits.

Customer Reviews (4)

Write a review
Reviews
06/10/2022

    I highly recommend this protein and the manufacturer's services to anyone in need of high-quality research materials and excellent technical support.

    12/06/2021

      I am very pleased with the excellent technical support provided by the manufacturer, which has been instrumental in solving some of my experimental problems.

      09/12/2017

        The ADPGK protein that I have obtained for my experiments is of exceptional quality and meets my experimental needs perfectly.

        11/21/2016

          Their prompt response and knowledge have been invaluable and have contributed significantly to the success of my research.

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