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ADRB3

  • Official Full Name

    adrenergic receptor, beta 3

  • Overview

    The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate;catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located;mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis.
  • Synonyms

    ADRB3; adrenergic receptor, beta 3; beta-3 adrenergic receptor; ADR B3; ADRB 3; ADRB3_HUMAN; ADRB3R; Adrenergic beta 3 receptor; B3AR; Beta 3 adrenoceptor; Beta 3 adrenoreceptor; Beta 3AR; Beta-3 adrenoceptor; Beta-3 adrenoreceptor; Beta3AR; FLJ99960; Beta-3 AR; beta 3-AR; OTTMUSP00000036279; beta3-adrenergic receptor; Adrb-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cavia porcellus (Guinea pig)
  • Cynomolgus Monkey
  • Felis catus (Cat) (Felis silvestris catus)
  • Goat
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADRB3-382H Recombinant Human ADRB3 Protein, GST-tagged Wheat Germ GST
Human ADRB3-147H Recombinant Human ADRB3 Mammalian Cell His
Human ADRB3-8998HCL Recombinant Human ADRB3 293 Cell Lysate HEK293 N/A
Human ADRB3-2436H Recombinant Human ADRB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ADRB3-979HF Recombinant Full Length Human ADRB3 Protein, GST-tagged In Vitro Cell Free System GST 408 amino acids
Human ADRB3-2436H-B Recombinant Human ADRB3 Protein Pre-coupled Magnetic Beads HEK293
Mouse ADRB3-1387M Recombinant Mouse ADRB3 Protein Mammalian Cell His
Mouse ADRB3-367M Recombinant Mouse ADRB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ADRB3-367M-B Recombinant Mouse ADRB3 Protein Pre-coupled Magnetic Beads HEK293
Rat ADRB3-545R Recombinant Rat ADRB3 Protein Mammalian Cell His
Rat ADRB3-201R-B Recombinant Rat ADRB3 Protein Pre-coupled Magnetic Beads HEK293
Rat ADRB3-201R Recombinant Rat ADRB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL-11729BF Recombinant Full Length Bovine Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-405)
Canis lupus familiaris (Dog) (Canis familiaris) RFL-29782CF Recombinant Full Length Dog Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-405)
Cavia porcellus (Guinea pig) RFL31657CF Recombinant Full Length Guinea Pig Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-351)
Cynomolgus Monkey ADRB3-281C Recombinant Cynomolgus ADRB3 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ADRB3-31C-B Recombinant Cynomolgus Monkey ADRB3 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey ADRB3-31C Recombinant Cynomolgus Monkey ADRB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Felis catus (Cat) (Felis silvestris catus) RFL5647FF Recombinant Full Length Cat Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-398)
Goat RFL30388CF Recombinant Full Length Goat Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-405)
Homo sapiens (Human) RFL-27793HF Recombinant Full Length Human Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-408)
Macaca mulatta (Rhesus macaque) RFL29983MF Recombinant Full Length Macaca Mulatta Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-418)
Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) RFL-31376MF Recombinant Full Length Meriones Unguiculatus Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-167)
Mus musculus (Mouse) RFL-21743MF Recombinant Full Length Mouse Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-400)
Ovis aries (Sheep) RFL36872OF Recombinant Full Length Sheep Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-405)
Rattus norvegicus (Rat) RFL-36779RF Recombinant Full Length Rat Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-400)
Rhesus Macaque ADRB3-261R Recombinant Rhesus monkey ADRB3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ADRB3-89R-B Recombinant Rhesus Macaque ADRB3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ADRB3-89R Recombinant Rhesus Macaque ADRB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sus scrofa (Pig) RFL2560SF Recombinant Full Length Pig Beta-3 Adrenergic Receptor(Adrb3) Protein, His-Tagged E.coli expression system His Full Length (1-407)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADRB3 Related Research Area

ADRB3 involved in several pathways and played different roles in them. We selected most pathways ADRB3 participated on our site, such as Adrenoceptors, Amine ligand-binding receptors, Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdrenoceptorsADRA1D;ADRA2C;ADRa1A;ADRA1B;ADRB1;ADRB3;ADRB2;ADRA2B;ADRA2A
Amine ligand-binding receptorsHRH3;CHRM1;ADRB3;CHRM3;CHRM4;CHRM5;ADRB2;ADRA2C;CHRM2
Calcium Regulation in the Cardiac CellADRB3;CHRM4;PKIB;GJA5;CX55.5;GJA4;RGS16;CHRM3;CHRM5
Calcium signaling pathwayPRKACAA;P2RX2;PHKG2;TACR1;CAMK2G;TBXA2R;TNNC1B;TACR2;BDKRB2
Class A/1 (Rhodopsin-like receptors)SSTR3;UTS2D;MLN;CCL35.2;OPN4A;PENKA;GPR4;ADRA2B;FFAR3
EndocytosisRAB5B;VPS45;CHMP1B;CHMP7;PLD1;RAB11AL;SNX6;SPG20;ARPC5LA
G alpha (s) signalling eventsPOMCB;ADCYAP1R1;ADM2;RLN3;GPBAR1;RAMP1;ADM2A;PTH2;CRHR1
GPCR downstream signalingSOUL3;PLEKHG2;FFAR3;ANXA1A;RGS1;PROKR1;SCT;TAC1;CHRM2

ADRB3 has several biochemical functions, for example, beta-3 adrenergic receptor binding, beta-adrenergic receptor activity, beta3-adrenergic receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRB3 itself. We selected most functions ADRB3 had, and list some proteins which have the same functions with ADRB3. You can find most of the proteins on our site.

Function Related Protein
beta-3 adrenergic receptor bindingARRDC3;ADRB3
beta-adrenergic receptor activityADRB3;ADRB1
beta3-adrenergic receptor activityADRB3A;ADRB3;ADRB3B
epinephrine bindingADRB3A;ADRA2A;ADRB2B;ADRB3;ADRB2A;ADRB1;ADRA2C;ADRB3B;ADRA2B
contributes_to norepinephrine binding
protein bindingTCAP;TAGLN;MED28;Chrng;DNAIC2;ERGIC1;IVL;PEX12;ZNF460
protein homodimerization activityGDNFA;MGLL;PGCP;PRMT2;CD247;MAP3K11;COMMD1;RABEP1;ALS2

ADRB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRB3.

Cav3; Nos3; Nos1

  • Q&As
  • Reviews

Q&As (15)

Ask a question
What are some potential risks or drawbacks of ADRB3-targeted therapies? 03/14/2022

Some potential risks or drawbacks of ADRB3-targeted therapies include an increased risk of adverse cardiovascular events, such as heart attack or stroke. Additionally, the long-term effects and safety of these therapies are not well established, and more research is needed to fully understand their potential risks and benefits.

Are there any FDA-approved ADRB3-targeted therapies available for medical use? 11/29/2021

No, there are currently no FDA-approved ADRB3-targeted therapies for medical use in the United States. However, several investigational drugs are in development and under clinical trials for conditions such as obesity and diabetes.

Can ADRB3 proteins play a role in cancer? 11/04/2021

There is limited research suggesting that ADRB3 proteins may play a role in certain types of cancer, including breast cancer and melanoma. However, the mechanisms of their action and the potential clinical implications are still unclear and require further investigation.

Are there any natural substances that can target ADRB3 proteins? 07/16/2021

Yes, several natural substances have been shown to activate or modulate ADRB3 proteins, including caffeine, bitter orange, and capsaicin (found in chili peppers). However, the efficacy and safety of using these substances for ADRB3-targeted therapies are not well established.

What are some potential benefits of ADRB3-targeted therapies? 03/14/2021

Some potential benefits of ADRB3-targeted therapies include weight loss, improved insulin sensitivity, and reduced risk of cardiovascular disease. These therapies may also have fewer side effects than some other weight loss medications, such as gastrointestinal issues or psychiatric effects.

Can ADRB3 proteins be targeted for the treatment of diabetes? 03/12/2021

ADRB3 proteins are involved in regulating glucose metabolism and insulin sensitivity, and their activation has been shown to increase glucose uptake and improve insulin sensitivity in muscle and adipose tissue. Therefore, ADRB3-targeted therapies are being explored as potential treatments for type 2 diabetes. However, more research is needed to determine the safety and efficacy of these interventions, as previous agonists have been associated with adverse effects, such as increased heart rate and blood pressure.

Is there a connection between ADRB3 proteins and exercise? 02/01/2021

Yes, ADRB3 proteins are believed to play a role in the metabolic and physiological responses to exercise, particularly in relation to energy metabolism and fat oxidation. Exercise has also been shown to increase the expression of ADRB3 proteins in adipose tissue, which may contribute to its beneficial effects on metabolic health.

Can ADRB3 proteins be used to enhance athletic performance? 09/06/2020

ADRB3 activation has been shown to increase athletic performance by improving endurance, energy metabolism, and muscle function. However, the use of ADRB3-targeted therapies for doping purposes is banned by the World Anti-Doping Agency, as these agents can also have adverse effects on cardiovascular function and may pose a risk to athletes' health.

Are there genetic mutations that affect ADRB3 proteins? 09/23/2019

Yes, genetic mutations in the ADRB3 gene have been identified and linked to various conditions, including obesity, metabolic syndrome, and hypertension. These mutations can affect the function and expression of ADRB3 proteins, leading to changes in lipid and glucose metabolism, energy expenditure, and cardiovascular function.

Can ADRB3 proteins be targeted for medical treatments? 01/14/2019

Yes, researchers are exploring the use of ADRB3-targeted therapies for treating obesity, diabetes, and other metabolic disorders. However, there is still much to learn about the role of ADRB3 proteins in these conditions and the potential risks and benefits of targeting them with medications.

What are some ongoing research areas related to ADRB3 proteins? 08/22/2018

Ongoing research areas related to ADRB3 proteins include the mechanisms of their action in adipose tissue and other organs, the role of ADRB3 genetic variations in metabolic disorders, and the development and testing of new ADRB3-targeted therapies for obesity, diabetes, and other conditions.

How do ADRB3 proteins interact with other signaling pathways in the body? 05/28/2018

ADRB3 proteins can interact with a variety of signaling pathways, including the adrenergic, insulin, and inflammatory pathways. For example, ADRB3 activation can stimulate lipolysis and increase fatty acid oxidation in adipose tissue, which can help prevent obesity and improve insulin sensitivity. Additionally, ADRB3 activation can modulate inflammation and immune function, which may have implications for the treatment of autoimmune and inflammatory diseases.

Can ADRB3 proteins be targeted for weight loss? 08/05/2017

There has been considerable interest in developing ADRB3-targeted therapies for weight loss, as activation of these receptors has been shown to increase energy expenditure, promote fat oxidation, and improve insulin sensitivity. However, clinical trials with ADRB3 agonists have yielded mixed results and have been associated with adverse effects, such as increased heart rate and blood pressure. Therefore, more research is needed to determine the safety and efficacy of ADRB3-targeted weight loss interventions.

How do ADRB3-targeted therapies differ from other weight loss treatments? 07/06/2017

ADRB3-targeted therapies aim to increase energy expenditure and promote fat oxidation, rather than simply reducing appetite or inhibiting nutrient absorption. They may also improve insulin sensitivity and metabolic function, which can have broader health benefits beyond weight loss. However, the safety and efficacy of these therapies remain uncertain, and more research is needed to determine their long-term effects on health outcomes.

What challenges remain in developing ADRB3-targeted therapies? 02/13/2016

One of the main challenges in developing ADRB3-targeted therapies is achieving selectivity and specificity, as ADRB3 proteins are structurally similar to other adrenergic receptors and can activate multiple signaling pathways. Another challenge is determining the optimal dose and treatment duration to achieve therapeutic effects without causing adverse effects. Additionally, more research is needed to elucidate the long-term safety and efficacy of these therapies in diverse patient populations.

Customer Reviews (4)

Write a review
Reviews
04/05/2022

    The protein is pure, stable, and consistently performs at a high standard, ensuring that my results will be reliable and reproducible.

    01/14/2018

      The ADRB3 protein provided by the manufacturer is of exceptional quality and is precisely what I require to conduct my experiments accurately.

      04/30/2017

        Their expertise and responsiveness have made the entire process smoother and more efficient, allowing me to focus entirely on my experiments.

        04/22/2017

          the technical support team provided by the manufacturer is outstanding and has been incredibly helpful in resolving any issues or concerns that may arise during my research.

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