AEN
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Official Full Name
apoptosis enhancing nuclease
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Synonyms
AEN; apoptosis enhancing nuclease; interferon stimulated exonuclease gene 20kDa like 1 , ISG20L1; apoptosis-enhancing nuclease; FLJ12484; FLJ12562; AEN_HUMAN; Interferon stimulated exonuclease gene 20kDa like 1; Interferon stimulated exonuclease gene 20kDa like 1, isoform CRA_a; Interferon-stimulated 20 kDa exonuclease-like 1; ISG20L1; pp12744; interferon stimulated exonuclease gene 20kDa-like 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
AEN involved in several pathways and played different roles in them. We selected most pathways AEN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AEN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
AEN has several biochemical functions, for example, exonuclease activity, nucleic acid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AEN itself. We selected most functions AEN had, and list some proteins which have the same functions with AEN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| exonuclease activity | EXO1;ISG20;EXO5;ISG20L2;TDP1;XRN1;LOC81691;RAD9;EXOSC9 |
| nucleic acid binding | ZNF644A;SRSF2A;ZFP39;ZCCHC4;ZBTB46;ZBED6;BICC2;ZFP57;ZKSCAN17 |
| protein binding | RASSF9;ARIH2;RIC8A;RNF34;ADAR;NOTCH4;STXBP2;GINS4;HLA-DRB4 |
AEN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AEN here. Most of them are supplied by our site. Hope this information will be useful for your research of AEN.
AAMP; ZBTB43; RBMY1A1; TRIM27; EMD
- Q&As
- Reviews
Q&As (10)
Ask a questionThe subcellular localization of AEN protein is determined by specific mechanisms and targeting sequences, which facilitate its transport and localization to specific cellular compartments.
Dysregulation or dysfunction of AEN protein can disrupt cellular functions, such as impaired DNA repair or altered apoptotic responses, and contribute to the development of diseases like cancer or neurodegenerative disorders.
Genetic variations or mutations in the AEN gene may impact the expression or function of AEN protein, potentially influencing cellular processes or disease susceptibility.
AEN protein may interact with other proteins, such as DNA repair factors or apoptotic regulators, forming protein complexes that influence cellular processes such as DNA repair or cell death.
AEN protein is implicated in specific cellular processes such as DNA repair and apoptosis, where it may play a role in maintaining genomic stability or regulating cell survival.
Experimental techniques such as molecular biology, cell biology, and biochemical assays can be employed to investigate the functional significance of AEN protein, including DNA repair assays or apoptosis assays.
Post-translational modifications or regulatory factors that modulate the activity or stability of AEN protein are not currently identified. Further research is necessary to explore these regulatory mechanisms.
The specific structural features or domains critical for the function or interaction of AEN protein are currently unknown, and further studies are needed to determine their role in cellular processes and molecular interactions.
The enzymatic activity or molecular function of AEN protein is currently unknown, and further experimental assays are needed to investigate its activity and molecular roles.
The tissue-specific expression patterns of AEN protein vary across different organs and cell types. Factors regulating its expression levels include transcriptional control and signaling pathways.
Customer Reviews (3)
Write a reviewExploring protein-protein interactions involved in neurotransmitter signaling.
Characterizing protein-protein interactions involved in chromosomal organization.
Determining protein-protein interaction interfaces using F枚rster resonance energy transfer.
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