AFF2
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Official Full Name
AF4/FMR2 family, member 2
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Overview
This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation. Alternate splicing results in multiple transcript variants. -
Synonyms
AFF2; AF4/FMR2 family, member 2; FMR2, fragile X mental retardation 2; AF4/FMR2 family member 2; FRAXE; AFF2_HUMAN; FMR2; FMR2P; Fragile X E mental retardation syndrome protein; fragile X mental retardation 2; Fragile X mental retardation 2 protein; fragile X mental retardation gene associated with FRAXE; mild or borderline mental retardation; MRX2; OTTHUMP00000024204; OX19; Protein FMR-2; Protein Ox19;
- Recombinant Proteins
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AFF2-406H | Recombinant Human AFF2 Protein, GST-tagged | Wheat Germ | GST |
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| Human | AFF2-26444TH | Recombinant Human AFF2 | Wheat Germ | N/A | 111 amino acids |
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| Mouse | Aff2-3231M | Recombinant Mouse Aff2, His-tagged | E.Coli or Yeast | His | 1272 |
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| Mouse | AFF2-1399M | Recombinant Mouse AFF2 Protein | Mammalian Cell | His |
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| Mouse | AFF2-375M-B | Recombinant Mouse AFF2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | AFF2-375M | Recombinant Mouse AFF2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
AFF2 involved in several pathways and played different roles in them. We selected most pathways AFF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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AFF2 has several biochemical functions, for example, G-quadruplex RNA binding, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF2 itself. We selected most functions AFF2 had, and list some proteins which have the same functions with AFF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-quadruplex RNA binding | Aff2;FXR1;DHX36;PATL2 |
| RNA binding | RNASET2;PATL2;BXDC2;GRB7;CWC22;DDX3X;U2AF1L4;EIF4EB;RC3H2 |
AFF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF2.
- Q&As
- Reviews
Q&As (10)
Ask a questionThe expression of AFF2 protein is regulated by specific factors and signaling pathways.
Genetic variations or mutations in the gene encoding AFF2 protein may impact its expression or function, influencing neuronal processes or disease susceptibility.
AFF2 protein holds potential as a target for modulating neuronal function or treating neurological disorders, and further research is needed to explore its implications for therapeutic interventions.
Dysregulation or dysfunction of AFF2 protein can disrupt neuronal homeostasis, impair synaptic plasticity, and contribute to neurological disorders.
AFF2 protein contributes to gene expression regulation or chromatin organization, and the underlying molecular mechanisms are currently being investigated.
Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AFF2 protein.
Various experimental techniques or assays, such as immunoprecipitation, electrophysiology, or animal models, have been used to study the functional significance of AFF2 protein.
The subcellular localization of AFF2 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.
AFF2 protein may interact with specific molecules or participate in protein complexes, which have functional implications in cellular processes.
AFF2 protein plays a role in neuronal development, synaptic function, or neurological disorders, and its function can be investigated using techniques like gene knockdown or overexpression studies.
Customer Reviews (3)
Write a reviewDeciphering protein-protein interactions in neurodevelopmental disorders for therapeutic targets.
Dissecting protein-protein interactions in autophagy flux for cellular clearance.
Probing protein-protein interactions in lipid signaling for metabolic regulation.
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