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AGAP5

  • Official Full Name

    ArfGAP with GTPase domain, ankyrin repeat and PH domain 5

  • Synonyms

    CTGLF2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; AGAP-5; centaurin-gamma-like family member 2; centaurin, gamma-like family, member 2;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AGAP5-3616H Recombinant Human AGAP5, His-tagged E.Coli or Yeast His 686
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AGAP5 involved in several pathways and played different roles in them. We selected most pathways AGAP5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AGAP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AGAP5 has several biochemical functions, for example, GTPase activator activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGAP5 itself. We selected most functions AGAP5 had, and list some proteins which have the same functions with AGAP5. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityGIT1;TBC1D13;FAM13A;TBC1D19;RGS5B;GDI2;PREX2;RAP1GAP;TBC1D10A
metal ion bindingPAN3;ZNF350;ZKSCAN3;GFI1AB;E4F1;MAT2A;CDH24;ADAM25;MORC1

AGAP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGAP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGAP5.

HSPB1

  • Q&As
  • Reviews

Q&As (20)

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What other functions besides SMA-related modifications might AGAP5 have? 08/26/2023

Apart from potential roles in SMA modification, AGAP5's involvement in membrane trafficking and cellular organization suggests broader functions in intracellular transport.

How is AGAP5 activity controlled? 01/18/2023

AGAP5 activity is regulated by factors like post-translational modifications, protein-protein interactions, and potential cellular localization changes.

What is the role of AGAP5 in the context of SMA? 12/18/2022

While the exact role of AGAP5 in SMA is not mentioned, its mutation suggests it could be part of the genetic landscape that influences the disease's severity.

Are there any known interactions between AGAP5 and other proteins? 10/25/2022

AGAP5's ankyrin repeat domains indicate potential interactions with other proteins, possibly influencing its activity and cellular functions.

Are there any other functions of AGAP5? 10/23/2022

Yes, AGAP5's ankyrin repeat and PH domain also suggest possible roles in protein-protein interactions and lipid binding, respectively.

Where is AGAP5 found in cells? 10/07/2022

AGAP5 is primarily located at the trans-Golgi network and endosomes within cells.

What is the significance of the mutations in AGAP5? 09/06/2022

The mutations in AGAP5 are noteworthy as they might contribute to altering the severity of SMA in the affected individuals, highlighting AGAP5's potential role as a genetic modifier.

Has AGAP5 been implicated in other diseases or conditions? 07/25/2022

AGAP5's role in cellular processes makes it a candidate for involvement in other diseases, although specific connections beyond SMA might require further research.

How were the mutations in AGAP5 identified?** 05/16/2022

The mutations in AGAP5 were likely identified through genetic sequencing and analysis of the patients' genomes, alongside mutations in TLL2 and VPS13A.

Can AGAP5 be a therapeutic target? 12/18/2021

Given its involvement in cellular processes, AGAP5 could potentially be targeted for therapeutic interventions aimed at modulating membrane trafficking and related disorders.

Are there any diseases associated with AGAP5 dysfunction? 09/27/2021

Although research is ongoing, AGAP5's dysregulation could potentially impact cellular trafficking processes and contribute to diseases like cancer and neurological disorders.

Are there any animal models used to study AGAP5 function? 03/17/2021

Animal models, such as genetically modified mice or cell-based models, could be used to study AGAP5's function and its effects on cellular processes.

Could AGAP5 have different effects in different tissues or cell types? 02/21/2021

Yes, the expression and function of AGAP5 might vary across tissues and cell types, contributing to different outcomes in different contexts.

What is the structure of AGAP5? 12/18/2020

AGAP5 comprises an ARF-GAP domain responsible for GTPase regulation, ankyrin repeat domains for protein interactions, and a PH domain possibly involved in lipid binding.

How might AGAP5 interact with other genetic modifiers in SMA? 06/18/2018

It's possible that AGAP5 interacts with other genetic modifiers to collectively impact the severity of SMA, demonstrating the complex genetic nature of the disease.

How does AGAP5 regulate membrane trafficking? 03/15/2018

AGAP5 influences vesicle budding, cargo sorting, and membrane fusion by modulating the activity of ARF6, a GTPase involved in endocytic pathways.

What is AGAP5 protein? 09/19/2017

AGAP5, also known as Arf-GAP with GTPase domain, Ankyrin repeat, and PH domain 5, is a protein involved in cellular processes like membrane trafficking and cytoskeleton regulation.

How does AGAP5 relate to the SMA discordant family case? 06/30/2017

In the SMA discordant family case, mutations were identified in the AGAP5 gene among other genes. These mutations could play a role in modifying the severity of SMA.

What does AGAP5 do? 09/04/2016

AGAP5 functions as a GTPase-activating protein (GAP) that regulates the activity of small GTPases, including ADP-ribosylation factor 6 (ARF6). It controls vesicle trafficking and membrane dynamics.

Why is AGAP5 important? 06/30/2016

AGAP5's role in membrane trafficking and cellular organization makes it crucial for maintaining proper intracellular transport and compartmentalization.

Customer Reviews (5)

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Reviews
02/06/2022

     Consistently achieving specific outcomes validated the product’s essential role in our studies.

    11/22/2021

      Agap5 consistently downregulated the expression of inflammatory markers.

      04/23/2021

        Our experiments with Agap5 showed no signs of protein aggregation.

        10/31/2017

           The product’s unique traits propelled our research to new levels of innovation.

          12/10/2016

            Using Protein Agap5, we obtained uniform results in various experimental conditions.

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