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AGPAT4

  • Official Full Name

    1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)

  • Overview

    This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis.
  • Synonyms

    AGPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta); 1-acyl-sn-glycerol-3-phosphate acyltransferase delta; dJ473J16.2; LPAAT delta; 1 acyl sn glycerol 3 phosphate acyltransferase delta; 1 acylglycerol 3 phosphate O acyltransferase 4; 1 AGP acyltransferase 4; Lysophosphatidic acid acyltransferase delta; 1-AGPAT 4; 1-AGP acyltransferase 4; lysophosphatidic acid acyltransferase-delta (LPAAT-delta); 1-AGPAT4; LPAAT-delta; RP3-473J16.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AGPAT4-9476H Recombinant Human AGPAT4, GST-tagged E.coli GST 24-300a.a.
Human AGPAT4-432H Recombinant Human AGPAT4 Protein, GST-tagged Wheat Germ GST
Human AGPAT4-8975HCL Recombinant Human AGPAT4 293 Cell Lysate HEK293 N/A
Human AGPAT4-932HF Recombinant Full Length Human AGPAT4 Protein, GST-tagged In Vitro Cell Free System GST 378 amino acids
Human AGPAT4-1048H Recombinant Human AGPAT4 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-319aa
Mouse AGPAT4-1420M Recombinant Mouse AGPAT4 Protein Mammalian Cell His
Mouse AGPAT4-390M Recombinant Mouse AGPAT4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AGPAT4-390M-B Recombinant Mouse AGPAT4 Protein Pre-coupled Magnetic Beads HEK293
Rat AGPAT4-561R Recombinant Rat AGPAT4 Protein Mammalian Cell His
Rat AGPAT4-217R Recombinant Rat AGPAT4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AGPAT4-217R-B Recombinant Rat AGPAT4 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL1519BF Recombinant Full Length Bovine 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta(Agpat4) Protein, His-Tagged E.coli expression system His Full Length (1-378)
Cynomolgus Monkey AGPAT4-284C Recombinant Cynomolgus AGPAT4 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey AGPAT4-34C Recombinant Cynomolgus Monkey AGPAT4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey AGPAT4-34C-B Recombinant Cynomolgus Monkey AGPAT4 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL23765HF Recombinant Full Length Human 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta(Agpat4) Protein, His-Tagged E.coli expression system His Full Length (1-378)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL32446MF Recombinant Full Length Macaca Fascicularis 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta(Agpat4) Protein, His-Tagged E.coli expression system His Full Length (1-378)
Mus musculus (Mouse) RFL2538MF Recombinant Full Length Mouse 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta(Agpat4) Protein, His-Tagged E.coli expression system His Full Length (1-378)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL4925PF Recombinant Full Length Pongo Abelii 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta(Agpat4) Protein, His-Tagged E.coli expression system His Full Length (1-378)
Rattus norvegicus (Rat) RFL34728RF Recombinant Full Length Rat 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta(Agpat4) Protein, His-Tagged E.coli expression system His Full Length (1-378)
Zebrafish AGPAT4-12236Z Recombinant Zebrafish AGPAT4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AGPAT4 Related Articles

AGPAT4 involved in several pathways and played different roles in them. We selected most pathways AGPAT4 participated on our site, such as Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerolipid metabolismAGK;ALDH9A1;LPIN2;LPIN1;Akr1b3;PPAP2D;DAK;AGPAT1;PNLIPRP2
Glycerophospholipid metabolismDGKE;PLA2G2E;PGS1;PPAP2CB;PLA2G4AA;LPIN2;ETNK2;STIL;MBOAT2B
Metabolic pathwaysITPK1A;OGDHA;AMPD1;ATPV0E2;CES1C;GALNT18;AMT;AK4;CD38
Phospholipase D signaling pathwayPTK2B;PLA2G4D;CXCR2;PLA2G4A;RRAS2;AVPR2;PDGFD;AGPAT5;PIP5K1C

AGPAT4 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT4 itself. We selected most functions AGPAT4 had, and list some proteins which have the same functions with AGPAT4. You can find most of the proteins on our site.

Function Related Protein
1-acylglycerol-3-phosphate O-acyltransferase activityAGPAT9L;AGPAT4;AGPAT1;AGPAT3;ABHD5;AGPAT9;LYCAT;AGPAT5;LCLAT1
protein bindingZNF624;PLCG1;GPN3;GP1BA;CBLB;XRCC1;ZNF593;MRE11A;VENTX

AGPAT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT4.

REL; CRK

Sankella, S; Garg, A; et al. Hepatic Gluconeogenesis Is Enhanced by Phosphatidic Acid Which Remains Uninhibited by Insulin in Lipodystrophic Agpat2 Mice*. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4762-4777(2014).
Cortes, VA; Smalley, SV; et al. Divergent Metabolic Phenotype between Two Sisters with Congenital Generalized Lipodystrophy Due to Double AGPAT2 Homozygous Mutations. A Clinical, Genetic and In Silico Study. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (24)

Ask a question
How does AGPAT4’s role intersect with lipid storage 10/25/2022

AGPAT4’s function can affect cellular lipid storage and energy utilization.

Can AGPAT4 play a role in cellular signaling pathways 03/29/2022

Yes, AGPAT4’s activity can impact lipid-mediated signaling processes within cells.

Can AGPAT4 impact lipid bilayer composition 03/26/2022

Yes, AGPAT4’s role influences the composition and fluidity of lipid bilayers.

How is AGPAT4’s role linked to lipid metabolism 09/26/2021

AGPAT4’s involvement is tied to the regulation of lipid metabolism and homeostasis.

Is AGPAT4’s role associated with organelle integrity 12/19/2020

Yes, AGPAT4’s involvement is connected to maintaining the integrity of organelle membranes.

Is AGPAT4’s function crucial for membrane formation 09/01/2020

Yes, AGPAT4’s activity is essential for the synthesis and maintenance of cellular membranes.

What is the function of AGPAT4 08/01/2020

AGPAT4 is an enzyme involved in the biosynthesis of phospholipids and lipid metabolism.

How does AGPAT4’s role relate to lipid second messengers 12/22/2019

AGPAT4’s involvement can impact the production of lipid-derived second messenger molecules.

How is AGPAT4’s activity studied in disease contexts 11/13/2019

Research investigates how AGPAT4’s dysfunction contributes to disease mechanisms.

How is AGPAT4’s function studied in lipidomics 09/05/2019

Research investigates AGPAT4’s impact on lipid composition and profiles of cellular membranes.

Is AGPAT4’s involvement related to lipid droplet dynamics 01/02/2019

Yes, AGPAT4’s function can influence the dynamics and formation of lipid droplets.

How does AGPAT4 contribute to lipid synthesis 11/11/2018

AGPAT4 catalyzes the addition of fatty acids to glycerol-3-phosphate, forming LPA.

Can AGPAT4 be linked to lipid-related diseases 10/14/2018

Yes, mutations in AGPAT4 can lead to metabolic disorders affecting lipid metabolism.

Can AGPAT4’s function be involved in cellular growth 12/01/2017

Yes, AGPAT4’s activity can influence cellular growth and proliferation through lipid metabolism.

How does AGPAT4 contribute to phospholipid remodeling 10/10/2017

AGPAT4’s role involves generating diverse phospholipids that contribute to remodeling.

Does AGPAT4 contribute to cellular response to stress 09/21/2017

Yes, AGPAT4’s function can be influenced by cellular stress and changes in metabolic state.

Does AGPAT4 play a role in lipid-mediated signaling 04/26/2017

Yes, AGPAT4’s activity can contribute to lipid-mediated signaling pathways within cells.

Can AGPAT4’s activity be regulated by cellular signals 03/13/2017

Yes, AGPAT4’s function can be modulated by intracellular signals and metabolic cues.

Where is AGPAT4 typically located in cells 12/26/2016

AGPAT4 is primarily found in the endoplasmic reticulum (ER) membrane.

How is AGPAT4’s impact on cellular health studied 10/27/2016

Research explores how AGPAT4’s function influences cellular health and function.

Can AGPAT4’s activity be targeted for therapeutics 10/02/2016

Yes, AGPAT4 is a potential therapeutic target for modulating lipid metabolism and related diseases.

How does AGPAT4 contribute to lipid homeostasis 07/28/2016

AGPAT4’s activity helps maintain lipid balance and cellular lipid levels.

How is AGPAT4’s function connected to membrane dynamics 05/12/2016

AGPAT4’s role can influence the dynamic behavior and curvature of cellular membranes.

Does AGPAT4’s function vary in different cell types 03/11/2016

Yes, AGPAT4’s activity and role can vary based on the specific cellular context.

Customer Reviews (5)

Write a review
Reviews
10/12/2021

     The comprehensive documentation streamlined the integration of the product into our experimental workflow.

    10/07/2018

      The knowledge gained from the product justified its cost, offering substantial value for investment.

      09/26/2017

         Replicating results emphasized the reliability and relevance of the product’s effects.

        01/07/2017

           The product consistently met our expectations, lending credibility to our findings.

          09/13/2016

             Comprehensive documentation streamlined our incorporation of the product into our research workflow.

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