agpat4
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  • Official Full Name
  • 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
  • Background
  • This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis.
  • Synonyms
  • AGPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta); 1-acyl-sn-glycerol-3-phosphate acyltransferase delta; dJ473J16.2; LPAAT delta; 1 acyl sn glycerol 3 phosphate acyltransferase delta; 1 acylglycerol 3 phosphate O acyltransferase 4; 1 AGP acyltransferase 4; Lysophosphatidic acid acyltransferase delta; 1-AGPAT 4; 1-AGP acyltransferase 4; lysophosphatidic acid acyltransferase-delta (LPAAT-delta); 1-AGPAT4; LPAAT-delta; RP3-473J16.2
Cat.#:AGPAT4-432HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AGPAT4 Protein, GST-tagged
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Cat.#:AGPAT4-9476HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGPAT4, GST-tagged
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Cat.#:AGPAT4-1420MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AGPAT4 Protein
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Cat.#:AGPAT4-561RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AGPAT4 Protein
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Cat.#:AGPAT4-284CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus AGPAT4 Protein, His-tagged
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Cat.#:AGPAT4-12236ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AGPAT4
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Cat.#:AGPAT4-8975HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AGPAT4 293 Cell Lysate
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Involved Pathway

AGPAT4 involved in several pathways and played different roles in them. We selected most pathways AGPAT4 participated on our site, such as Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerolipid metabolism
AKR1B1L; AGPAT4; DGAT1; LCLAT1; ALDH1B1; AGPAT2; PNPLA3; GK; LPL; GLYCTK
Glycerophospholipid metabolism
PLA2G15; PPAP2B; EPT1; PPAP2C; CHKA; PGS1; GPAM; PLA2G3; PLA2G16; LYPLA1
Metabolic pathways
PGD; CERS5; GOT1; CYP2P9; GANAB; GNS; MLYCD; FUT1; DHRS9; GALNT14
Phospholipase D signaling pathway
CYTH2; IL-8; CXCR2; AGTR1A; RRAS2; PIK3CA; GAB1; F2R; KIT; AGTR1B

Protein Function

AGPAT4 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT4 itself. We selected most functions AGPAT4 had, and list some proteins which have the same functions with AGPAT4. You can find most of the proteins on our site.
Function
Related Protein
Function 1-acylglycerol-3-phosphate O-acyltransferase activity
Related Protein LYCAT; AGPAT4; AGPAT1; AGPAT2; AGPAT3; LCLAT1; LPCAT2; AGPAT9L; AGPAT5; AGPAT9
Function protein binding
Related Protein RANBP3; VPS52; PPIF; WDFY2; SCYL2; POU1F1; a; WTAP; MBD3; YWHAB

Interacting Protein

AGPAT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT4.
REL; CRK

AGPAT4 Related Articles

Sankella, S; Garg, A; et al. Hepatic Gluconeogenesis Is Enhanced by Phosphatidic Acid Which Remains Uninhibited by Insulin in Lipodystrophic Agpat2 Mice*. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4762-4777(2014).
Cortes, VA; Smalley, SV; et al. Divergent Metabolic Phenotype between Two Sisters with Congenital Generalized Lipodystrophy Due to Double AGPAT2 Homozygous Mutations. A Clinical, Genetic and In Silico Study. PLOS ONE 9:-(2014).