AGTR1A
-
Official Full Name
angiotensin II receptor, type 1a
-
Synonyms
AGTR1A; angiotensin II receptor, type 1a; type-1A angiotensin II receptor; Angiotensin II type 1a receptor; AT1; AT1A; AT1AR; Type 1 angiotensin II receptor; OTTMUSP00000000614; angiotensin receptor 1; angiotensin receptor 1a; angiotensin II type-1A receptor; AG2S; AT2R1; Agtr1; AT2R1A; Agtr-1a; AI551199; Angtr-1a; 1810074K20Rik;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Mouse
- Mus musculus (Mouse)
- Rat
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|GST
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Mouse | AGTR1A-1430M | Recombinant Mouse AGTR1A Protein | Mammalian Cell | His | ||
Mouse | AGTR1A-397M | Recombinant Mouse AGTR1A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | AGTR1A-397M-B | Recombinant Mouse AGTR1A Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | AGTR1A-566R | Recombinant Rat AGTR1A Protein | Mammalian Cell | His | ||
Rat | Agtr1a-1768R | Recombinant Rat Agtr1a protein, His & GST-tagged | E.coli | His/GST | Asp263~Glu359 (Accession # P25095) | |
Rat | AGTR1A-222R | Recombinant Rat AGTR1A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | AGTR1A-222R-B | Recombinant Rat AGTR1A Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mus musculus (Mouse) | RFL-2154MF | Recombinant Full Length Mouse Type-1A Angiotensin Ii Receptor(Agtr1A) Protein, His-Tagged | E.coli expression system | His | Full Length (1-359AA) |
- Involved Pathway
- Protein Function
- Interacting Protein
- AGTR1A Related Signal Pathway
AGTR1A involved in several pathways and played different roles in them. We selected most pathways AGTR1A participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGTR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Calcium signaling pathway | GRM1;CACNA1DA;CYSLTR1;ADRB3A;HTR2B;ATP2A2B;SLC8A1A;TACR3L;PRKCB |
cGMP-PKG signaling pathway | MAPK3;IRS2;PPP3R2;PLCB1;MEF2C;CALML5;MAP2K1;PRKG2;KCNMB3 |
Phospholipase D signaling pathway | CYTH4;LPAR2;GRM4;PLCG1;PDGFB;PLD2;LPAR6;FCER1G;GAB2 |
Neuroactive ligand-receptor interaction | TBXA2R;TAAR12G;TAAR14B;CNR2;F2RL3;CALCR;F2R;PRP2;PTGER4C |
Adrenergic signaling in cardiomyocytes | ADCY2B;SCN5A;AKT1;PPP2R5EA;PPP1CB;CACNG6;CAMK2D1;CACNB1;MAPK14 |
Vascular smooth muscle contraction | KCNMB3;CYP4A12A;ACTG2;PRKG1A;PRKCHA;CACNA1C;PLA2G1B;PLA2G4A;MYLK4 |
Renin-angiotensin system | KLK1;MRGPRD;MAS1;KLK1B1;CPA3;ACE;KLK1B22;ATP6AP2;KLK1B5 |
Renin secretion | ACE;CALM4;PDE3B;ORAI1;CLCA2;Ren1;PRKACG;CALML3;REN |
Aldosterone synthesis and secretion | ADCY8;CAMK2A;AGTR1B;NR4A1;ATF1;LIPE;NPR1;CREB3;ITPR3 |
Pathways in cancer | WNT1;FOXO1;MSH3;BMP4;IL6;FGF3;STAT3;PRKACG;LAMB2 |
AGTR1A has several biochemical functions, for example, D1 dopamine receptor binding, G-protein alpha-subunit binding, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AGTR1A itself. We selected most functions AGTR1A had, and list some proteins which have the same functions with AGTR1A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
D1 dopamine receptor binding | DLG4;AGTR1A;CAV2;GNAS;ARRB2;DRD3;PTPN11;ATP1A3 |
G-protein alpha-subunit binding | RGS4;RIC8A;DRD1;DRD1A;HTR2B;AGTR1A;RIC8B;HTR2A;F2RL1 |
G-protein coupled receptor activity | RXFP2A;TAAR10A;OLFR488;SETD6;TACR1A;O3far1;GPR65;GPR26;HTR1E |
angiotensin type I receptor activity | AGTR1B;AGTR1;AGTR1A |
angiotensin type II receptor activity | RXFP3.2B;AGTR1B;APLNRA;AGTR1A;AGTR2;CXCR3.2;APLNRB;RXFP4;AGTRAP |
bradykinin receptor binding | AGTR1;ACE;AGTR1A |
peptide hormone binding | GCGR;RXFP2;GIPR;PTH1R;INHBA;ECE1;PTH1RA;SLC40A1;NPR2 |
protein binding | UBE2H;RAD51;AGBL4;HSD17B8;MPP2;HNF4A;LTC4S;NEK6;NOTCH2 |
protein heterodimerization activity | PRPH;KCNB2;SYT5;HIST1H2B7;SNX6;GTF2A1;SOX17;MCL1A;SMAD1 |
protein kinase binding | TICAM1;TSKS;GOLGA2;FGR;ARHGEF7;IL12RB2;GPRC5B;MAVS;TRAF4 |
protein self-association | CTSC;TTN;SLC9A3R1;ZFP639;TMEM190;PABPN1;VAMP2;ACVR2A;CCDC88C |
signal transducer activity | GPR183A;OLFR502;SHC3;TRIM55;GNAO1B;TAS2R126;FPR-RS6;PLCXD2;GNG5 |
AGTR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGTR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of AGTR1A.
Agtrap; Ankrd1
- Q&As
- Reviews
Q&As (10)
Ask a questionAGTR1A activation leads to vasoconstriction by stimulating smooth muscle cell contraction, thereby affecting vascular tone and blood pressure.
Techniques such as co-immunoprecipitation (Co-IP) or proximity-based assays like the fluorescence resonance energy transfer (FRET) can be utilized to investigate protein-protein interactions involving AGTR1A.
Angiotensin II is the primary ligand for AGTR1A, but there are also selective agonists and antagonists that can modulate its activity for research and therapeutic purposes.
Genetic polymorphisms in AGTR1A have been associated with variable responses to ARBs and other antihypertensive medications, affecting treatment outcomes.
Lab researchers can use techniques like phospho-specific antibodies, ELISA assays, or luciferase reporter assays to assess the activation and downstream signaling of AGTR1A pathways.
AGTR1A signaling has been implicated in insulin resistance, glucose metabolism, and the development of metabolic disorders such as obesity and diabetes.
AGTR1A activates various signaling pathways, including phospholipase C (PLC), protein kinase C (PKC), mitogen-activated protein kinases (MAPKs), and intracellular calcium release.
AGTR1A has extracellular domains and specific amino acid residues within the transmembrane region that facilitate angiotensin II binding and receptor activation.
AGTR1A is activated when angiotensin II binds to the receptor, leading to conformational changes that initiate intracellular signaling cascades.
High-throughput screening (HTS) methods, such as cell-based assays or binding assays using radiolabeled ligands, can be employed to identify and evaluate potential compounds targeting AGTR1A.
Customer Reviews (5)
Write a reviewThe customer service was fantastic—helpful, friendly, and made the ordering process a breeze!
Quick delivery and secure packaging ensured my recombinant proteins arrived in perfect condition.
Super impressed with the reliable recombinant proteins I received at such a reasonable cost
The stability of this protein is unparalleled. It remains intact and active even under challenging conditions, ensuring reliable and reproducible results.
Couldn't be happier with the high-quality recombinant proteins I got at such an amazing price.
Ask a Question for All AGTR1A Products
Required fields are marked with *
My Review for All AGTR1A Products
Required fields are marked with *