agtr2
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  • Official Full Name
  • angiotensin II receptor, type 2
  • Background
  • The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation.
  • Synonyms
  • AGTR2; angiotensin II receptor, type 2; angiotensin receptor 2; type-2 angiotensin II receptor; AT2; MRX88; angiotensin II type-2 receptor; ATGR2
Cat.#:AGTR2-30HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human AGTR2, GST-tagged
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Cat.#:AGTR2-31HTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human AGTR2
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Cat.#:AGTR2-33HTag:His/SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGTR2 protein, His/SUMO-tagged
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Cat.#:AGTR2-397HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human AGTR2
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Cat.#:AGTR2-2130ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AGTR2
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Cat.#:AGTR2-8969HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AGTR2 293 Cell Lysate
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Involved Pathway

AGTR2 involved in several pathways and played different roles in them. We selected most pathways AGTR2 participated on our site, such as ACE Inhibitor Pathway, Adrenergic signaling in cardiomyocytes, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGTR2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ACE Inhibitor Pathway
CYP11B2; ACE; AGT; AGTR2; CTSG; ATP6AP2; CMA1; AGTR1
Adrenergic signaling in cardiomyocytes
PPP1CB; CREB3L1; CALM4; CACNG2; AKT3A; ADRB2; ATP1A2A; SCN5A; CACNA1C; TMEM8C
Class A/1 (Rhodopsin-like receptors)
CCBP2; RLN2; CHRM2; CNR1; RGS1; SSTR4; GPR31; CCRL2; FPR-RS4; CHRM1
G alpha (i) signalling events
OPN1SW; TAS2R16; CCR8; OPN1MW; DRD3; OPN1MW2; AMCF-II; OPN1LW2; OXGR1A.1; HCAR1-2
GPCR downstream signaling
EDN2; APLNR; GPR132B; PROKR2; RXFP2B; RHOB; PROKR1A; FPR-RS4; OPN1SW; RGS19
GPCR ligand binding
OXGR1A.3; OPN5; FZD10; EMR4; NPS; QRFP; CXCL13; GPR55A; HCRT; TRH
GPCRs, Class A Rhodopsin-like
SSTR1; AGTR2; DRD4; GPR85; GPR68; OPN3; GPR45; GPR27; CHRM4; CCR7
Neuroactive ligand-receptor interaction
CHRM2A; TAAR12H; GABRR1; TAAR8C; P2RY6; CSH1; GRIN2B; TAAR12G; NMBR; GCGR

Protein Function

AGTR2 has several biochemical functions, for example, angiotensin type II receptor activity, peptide hormone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGTR2 itself. We selected most functions AGTR2 had, and list some proteins which have the same functions with AGTR2. You can find most of the proteins on our site.
Function
Related Protein
Function angiotensin type II receptor activity
Related Protein AGTR2; RXFP4; AGTR1B; APLNRB; APLNRA; AGTR1A; AGTRAP; CXCR3.2; RXFP3.2B; AGTR1
Function peptide hormone binding
Related Protein MC3R; AGTR1A; CRHR2; GHRHR; SLC40A1; GALR1; NPR2; PRLR; INHBA; NPR1
Function protein binding
Related Protein TRAF3IP2; TGIF2LY; ACTR8; PIAS1; TMIGD2; HNRNPUL1; DAZL; CLDN18; TPM4; TRMT1
Function receptor antagonist activity
Related Protein IL18BP; DKK1; ADH7; LRPAP1; AGTR2; ESR2
Function transcription factor binding
Related Protein SMAD2; PURA; APBB1; RB1; PPP1R13BA; HDAC4; NEUROD1; SIRT2; DOT1L; Trl

Interacting Protein

AGTR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGTR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGTR2.
TIMP3; AGT; AGT