AGTR2
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Official Full Name
angiotensin II receptor, type 2
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Overview
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. -
Synonyms
AGTR2; angiotensin II receptor, type 2; angiotensin receptor 2; type-2 angiotensin II receptor; AT2; MRX88; angiotensin II type-2 receptor; ATGR2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Rat
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- Flag
- His|SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
AGTR2 involved in several pathways and played different roles in them. We selected most pathways AGTR2 participated on our site, such as ACE Inhibitor Pathway, Adrenergic signaling in cardiomyocytes, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGTR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ACE Inhibitor Pathway | CMA1;CYP11B2;AGTR2;ATP6AP2;ACE;AGTR1;AGT;CTSG |
| Adrenergic signaling in cardiomyocytes | PIK3CD;ADRB2;CACNA1DA;ATP1B3B;PIK3R2;PRKACB;CAMK2D1;BCL2A;KCNE1 |
| Class A/1 (Rhodopsin-like receptors) | SSTR3;NPSR1;PROKR2;GPR4;NTS;ADORA2A;GRP;RGS1;OXGR1A.1 |
| G alpha (i) signalling events | SOUL4;PTGDR2;APLNR;SSTR4;CCR7;LPAR5A;NMUR1;RLN3A;PNOC |
| GPCR downstream signaling | GPBAR1;DRD5;PTHRP2;ADORA3;CNR1;CRH;EDN1;RGS1;RHOB |
| GPCR ligand binding | RGS1;PTHLHA;PPY;EMR2;SST1.1;FZD10;NMU;GPR68;S1PR1 |
| GPCRs, Class A Rhodopsin-like | ACKR4;CYSLTR1;GPR6;GPR63;FPR-RS4;AGTR2;LTB4R;GPR75;GPR18 |
| Neuroactive ligand-receptor interaction | TAAR15;LOC100328615;GHRHRL;GLRBB;GH2;GABRB2;TAAR8B;CHRM5B;ADORA2AA |
AGTR2 has several biochemical functions, for example, angiotensin type II receptor activity, peptide hormone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGTR2 itself. We selected most functions AGTR2 had, and list some proteins which have the same functions with AGTR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| angiotensin type II receptor activity | AGTR1;RXFP3.2B;RXFP4;APLNRB;AGTR1A;AGTRAP;APLNRA;AGTR2;AGTR1B |
| peptide hormone binding | NPR3;EDNRB;INHBA;PTH1RA;GALR2;MC4R;GHR;GALR3;ANXA5 |
| protein binding | GGA1;RPN1;JIP1;FAT4;NKX2-1;RTN1;TARSL2;SIRT4;HPN |
| receptor antagonist activity | DKK1;LRPAP1;AGTR2;ADH7;ESR2;IL18BP |
| transcription factor binding | HEY2;REST;KLF5;GPX3;TAF1;ATOH8;PPP1R13BA;APBB1;BCL10 |
AGTR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGTR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGTR2.
TIMP3; AGT; AGT
- Q&As
- Reviews
Q&As (10)
Ask a questionEpigenetic modifications, such as DNA methylation and histone acetylation, have been implicated in regulating AGTR2 expression. Hypermethylation of the AGTR2 gene promoter has been observed in certain pathological conditions, suggesting a potential mechanism for altered AGTR2 expression and associated diseases.
AGTR2 activation can exert anti-fibrotic and anti-hypertrophic effects in the heart after myocardial infarction. AGTR2 activation promotes cardiomyocyte survival, limits adverse remodeling, and improves cardiac function, indicating its therapeutic potential in post-MI cardiac remodeling.
AGTR2 can cross-talk with other receptors and signaling pathways, such as the insulin-like growth factor 1 receptor and the Wnt/β-catenin pathway, to regulate cellular processes.
Several transcription factors, including Sp1, AP-1, and NF-κB, can bind to the promoter region of AGTR2 and modulate its gene expression.
AGTR2 may have dual roles in cancer progression, acting as a tumor suppressor or a promoter depending on the specific cancer type.
Phosphorylation, ubiquitination, and glycosylation are among the post-translational modifications that can modulate AGTR2 function and signaling.
Yes, certain genetic variations in AGTR2 have been linked to various diseases, including hypertension, preeclampsia, and neurological disorders.
AGTR2 can activate multiple signaling pathways, including phosphatases, kinases, and nitric oxide synthase.
AGTR2 is expressed in various tissues, including the cardiovascular system, brain, kidney, and reproductive organs.
AGTR2 has been implicated in cardiovascular development, blood pressure regulation, and vascular remodeling.
Customer Reviews (5)
Write a reviewIt worked seamlessly in my experiments, yielding consistent and reliable results.
The protein I purchased exceeded my expectations. It was highly pure and performed exceptionally well in my protein-protein interaction studies.
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It was easy to use, and the results were reproducible, giving me confidence in my data.
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