AIFM3
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Official Full Name
apoptosis-inducing factor, mitochondrion-associated, 3
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Synonyms
AIFM3; apoptosis-inducing factor, mitochondrion-associated, 3; apoptosis-inducing factor 3; AIFL; FLJ30473; apoptosis-inducing factor like; FLJ45137;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AIFM3-9505H | Recombinant Human AIFM3, His-tagged | E.coli | His | 355-598a.a. | |
Human | AIFM3-475H | Recombinant Human AIG1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | AIFM3-8952HCL | Recombinant Human AIFM3 293 Cell Lysate | HEK293 | N/A | ||
Human | AIFM3-2699H | Recombinant Human AIFM3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | AIFM3-957HF | Recombinant Full Length Human AIFM3 Protein, GST-tagged | In Vitro Cell Free System | GST | 598 amino acids | |
Mouse | AIFM3-1453M | Recombinant Mouse AIFM3 Protein | Mammalian Cell | His | ||
Mouse | AIFM3-413M | Recombinant Mouse AIFM3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Aifm3-1575M | Recombinant Mouse Aifm3 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | AIFM3-413M-B | Recombinant Mouse AIFM3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | AIFM3-6904Z | Recombinant Zebrafish AIFM3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- AIFM3 Related Articles
AIFM3 involved in several pathways and played different roles in them. We selected most pathways AIFM3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AIFM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AIFM3 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, flavin adenine dinucleotide binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AIFM3 itself. We selected most functions AIFM3 had, and list some proteins which have the same functions with AIFM3. You can find most of the proteins on our site.
Function | Related Protein |
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2 iron, 2 sulfur cluster binding | FXN;FECH;AOX1;XDH;FDX1B;ISCUB;GLRX2;ISCU;ISCA1 |
flavin adenine dinucleotide binding | DUS3L;AIFM3;ACAD11;GSR;GCDH;GCDHB;DUS4L;TXNRD3;ACOX2 |
metal ion binding | EGR2;KLF12A;CSRP1B;ZFP131;CYP2C39;ZNF740B;PPP4C;CSNK2B;UNC13B |
oxidoreductase activity | AKR1B7;ALOX12E;SDR16C6;FRRS1;FOXRED1;RDH8B;CYP3A41A;OXR1;QDPRB2 |
AIFM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIFM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AIFM3.
PRNP
- Q&As
- Reviews
Q&As (14)
Ask a questionYes, AIFM3 has been shown to be upregulated in various cancers, including breast cancer and lung cancer, and its dysregulation has been implicated in cancer progression and metastasis.
Dysregulation of AIFM3 has been implicated in various diseases, including cancer, Alzheimer's disease, and Parkinson's disease.
It is possible that AIFM3 could be used as a biomarker for disease diagnosis or prognosis in the future. However, more research is needed to validate its potential as a biomarker. For example, a recent study has found that AIFM3 expression is decreased in the blood of patients with chronic obstructive pulmonary disease, suggesting that it could be a potential biomarker for this disease.
AIFM3 is a member of the AIF (Apoptosis-Inducing Factor) family of proteins, which also includes AIF and AIFM1. AIFM3 shares some structural and functional similarities with other AIF family proteins, but they have distinct roles in regulating mitochondrial function and cell death processes.
AIFM3 expression is regulated by various transcription factors and epigenetic modifications. For example, the transcription factor NRF2 promotes AIFM3 expression by binding to its promoter region. Histone acetylation and DNA methylation also play a role in the regulation of AIFM3 expression.
There is currently no evidence supporting the use of AIFM3 as a biomarker for cancer diagnosis or prognosis. However, its dysregulation in cancer suggests that it may be a target for cancer therapy.
Yes, there are ongoing studies investigating the role of AIFM3 in various diseases. For example, a recent study has found that AIFM3 expression is decreased in the brains of patients with Alzheimer's disease, suggesting that AIFM3 may play a role in the pathogenesis of this disease. Other studies are investigating the potential of AIFM3 as a therapeutic target for mitochondrial diseases and neurological disorders.
Yes, mutations in the AIFM3 gene have been associated with various mitochondrial diseases, such as mitochondrial encephalomyopathy and mitochondrial DNA depletion syndrome. These diseases are characterized by defects in mitochondrial function and energy metabolism.
AIFM3 expression is regulated at the transcriptional level by various transcription factors, including HIF-1α and NF-κB.
Yes, AIFM3 has been shown to be downregulated during aging, and its dysregulation has been implicated in aging-related degeneration and cellular senescence.
Yes, targeting AIFM3 can be a potential therapeutic strategy for mitochondrial diseases or neurological disorders. For example, increasing AIFM3 expression or activity could improve mitochondrial function and energy metabolism in patients with mitochondrial diseases. In contrast, inhibiting AIFM3 activity could be beneficial in neurological disorders where excessive AIFM3 activity is detrimental, such as in epilepsy.
Various techniques can be used to study AIFM3, including genetic and epigenetic analyses, protein expression and purification, cell culture and functional assays, and mouse models. For example, to study the role of AIFM3 in mitochondrial function, researchers can use techniques such as mitochondrial membrane potential analysis, respiration assays, and ATP production assays.
Yes, mutations in the AIFM3 gene have been associated with various diseases, including autism spectrum disorders and X-linked intellectual disability.
Yes, AIFM3 is a potential target for drug development in various diseases, including cancer and neurodegenerative diseases. However, extensive research is needed to determine the therapeutic potential and safety of targeting AIFM3.
Customer Reviews (4)
Write a reviewIts remarkable purity, consistency, and stability make it the perfect candidate to drive my research forward and produce precise and dependable results.
the manufacturer of the AIFM3 protein offers exceptional technical support, reinforcing the overall excellence of their product.
Their expert assistance effectively addresses any challenges or inquiries that may arise during my experiments, ensuring a seamless workflow and the successful resolution of any issues.
The AIFM3 protein presents itself as an outstanding choice that surpasses my expectations in terms of quality and suitability for my experimental requirements.
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