akr1c2
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  • Official Full Name
  • Aldo-keto reductase family 1 member C2
  • Background
  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
  • Synonyms
  • AKR1C2; AKR1C1; Aldo-keto reductase family 1 member C2
Cat.#:AKR1C2-18HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AKR1C2, MYC/DDK-tagged
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Cat.#:AKR1C2-412HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKR1C2 Protein, GST-tagged
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Cat.#:AKR1C2-456HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C2, His tagged
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Cat.#:AKR1C2-858HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C2 Protein, His-tagged
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Cat.#:AKR1C2-599RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKR1C2 Protein
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Cat.#:AKR1C2-8930HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AKR1C2 293 Cell Lysate
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Involved Pathway

AKR1C2 involved in several pathways and played different roles in them. We selected most pathways AKR1C2 participated on our site, such as Benzo(a)pyrene metabolism, Bile acid and bile salt metabolism, Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Benzo(a)pyrene metabolism
FAM84B; CYP3A4; AKR1A1; CYP1A1; AKR1C4; AKR1C2; CYP1B1
Bile acid and bile salt metabolism
CYP8B2; SLC27A5; ACOT8; AKR1C6; SLC27A2; SCP2B; SLC27A2A; SLCO1B1; AKR1C4; Alb
Chemical carcinogenesis
ADH1A; CYP2C70; CYP2C55; MGST3; GSTP1; UGT1A4; CYP3A41A; SULT1A1; Nat3; GSTA5
Metabolism
VAPB; NUDT3; ACOT11A; APOEA; HSD17B11; TCN1; GLYATL1; CPNE3; AQP1A.1; PDK2B
Metabolism of lipids and lipoproteins
CDIPT; ANKRD1; TPTE; SUMF2; MED9; TIAM2; PPM1LA; LBR; CYP2U1; CYP27B1
Metabolism of xenobiotics by cytochrome P450
AKR1C2; GSTK1; CYP2F1; ADH2-2; PRKRA; ADH2-1; AKR1C4; CYP2S1
Steroid hormone biosynthesis
HSD17B12A; HSD17B7; CYP1A; CYP3A41A; CYP21A1; AKR1D1; HSD3B1; CYP2C39; CYP7A1A; CYP3A7-CYP3AP1
Synthesis of bile acids and bile salts
BRSK2; SLC27A2A; AKR1C2; SCP2B

Protein Function

AKR1C2 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, bile acid binding, carboxylic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C2 itself. We selected most functions AKR1C2 had, and list some proteins which have the same functions with AKR1C2. You can find most of the proteins on our site.
Function
Related Protein
Function alditol:NADP+ 1-oxidoreductase activity
Related Protein AKR1B8; ADH4; AKR1C3; AKR1B7; Akr1b3; AKR1A1; AKR1C2; AKR1C21; AKR7A5; AKR7A2
Function bile acid binding
Related Protein PLA2G1B; NR1H4; FABP1; AKR1C2; FABP6; AKR1C21; PYGL; FABP10A; STARD5
Function carboxylic acid binding
Related Protein PCK1; GRHPR; GOT1; HMGCL; AKR1C21; HIF1AN; AKR1C2
Function ketosteroid monooxygenase activity
Related Protein AKR1C2; AKR1C21; AKR1C3
Function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Related Protein DCXR; AKR1C2; NDUFS7; CBR1; AKR1C21; AKR1C3; DHRS4; AKR1C6; AKR1C4
Function phenanthrene 9,10-monooxygenase activity
Related Protein MICAL2; AKR1C3; MICAL2B; AKR1C2; AKR1C21
Function trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Related Protein AKR1C2; DHDH; AKR1C3; AKR1C21

Interacting Protein

AKR1C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C2.
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