aldh5a1
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  • Official Full Name
  • aldehyde dehydrogenase 5 family, member A1
  • Background
  • This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms
  • ALDH5A1; aldehyde dehydrogenase 5 family, member A1; succinate-semialdehyde dehydrogenase, mitochondrial; SSADH; SSDH; succinate semialdehyde dehydrogenase; aldehyde dehydrogenase family 5 member A1; mitochondrial succinate semialdehyde dehydrogenase; NAD
Cat.#:ALDH5A1-1324HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ALDH5A1 Protein (48-535 aa), His-tagged
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Cat.#:ALDH5A1-26496THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH5A1, His-tagged
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Cat.#:ALDH5A1-27041THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH5A1, His-tagged
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Cat.#:ALDH5A1-2821HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH5A1, His-tagged
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Cat.#:ALDH5A1-450HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDH5A1 Protein, GST-tagged
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Cat.#:ALDH5A1-9562HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH5A1, His-tagged
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Cat.#:ALDH5A1-6188ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ALDH5A1
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Cat.#:ALDH5A1-60HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ALDH5A1 cell lysate
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Involved Pathway

ALDH5A1 involved in several pathways and played different roles in them. We selected most pathways ALDH5A1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Butanoate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alanine, aspartate and glutamate metabolism
GLULA; AGXT2; GLUD1A; ADSSL1; ASNS; ASPA; ADSS; GLUD1; GFPT1; AGXT
Butanoate metabolism
ABAT; OXCT2B; ACSM1; GAD1; ACSM4; ECHS1; ACAT2; ACAT1; HMGCLL1; BDH2
Metabolic pathways
PIGH; GALNT5; CMPK2; ENO2; CD38; PAPSS2; CKMT2; MIBP; PIGN; UGT1A6B

Protein Function

ALDH5A1 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity, protein homodimerization activity, succinate-semialdehyde dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH5A1 itself. We selected most functions ALDH5A1 had, and list some proteins which have the same functions with ALDH5A1. You can find most of the proteins on our site.
Function
Related Protein
Function aldehyde dehydrogenase (NAD) activity
Related Protein ALDH9A1A.1; Aldh1a7; ALDH4A1; ALDH1A1; ALDH7A1; ALDH5A1; ALDH9A1B; ALDH3A1; ALDH1A3; ALDH6A1
Function protein homodimerization activity
Related Protein CADM1; PDK2; ADD2; RAB11FIP4A; CHEK2; PRPS2; CSF1; ADRA2A; C9orf142; CEBPA
Function succinate-semialdehyde dehydrogenase (NAD+) activity
Related Protein ALDH5A1
Function succinate-semialdehyde dehydrogenase [NAD(P)+] activity
Related Protein ALDH5A1

Interacting Protein

ALDH5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH5A1.
NR3C1

ALDH5A1 Related Articles

Zuo, QS; Li, D; et al. Study on the Regulatory Mechanism of the Lipid Metabolism Pathways during Chicken Male Germ Cell Differentiation Based on RNA-Seq. PLOS ONE 10:-(2015).
Wang, L; Guo, HJ; et al. Enrichment and characterization of cancer stem-like cells from a cervical cancer cell line. MOLECULAR MEDICINE REPORTS 9:2117-2123(2014).