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ALDOAB

Species Cat.# Product name Source (Host) Tag Protein Length Price
Zebrafish ALDOAB-12421Z Recombinant Zebrafish ALDOAB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ALDOAB involved in several pathways and played different roles in them. We selected most pathways ALDOAB participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDOAB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisDLDH;ALDH9A1A.1;LDHAL6B;PGK2;GPI1;ALDH3B2;LDHC;HK1;PGAM2
Pentose phosphate pathwayPFKMA;PFKP;ALDOCB;PGLS;GPIA;TKTL1;ALDOA;PGM2;GPI1
Fructose and mannose metabolismSORD;AKR1B1;TIGARB;PFKMA;MPI;PFKL;GMDS;FBP1B;PMM2
Metabolic pathwaysHK2;SMPD2;ADH2-2;POLA2;NDUFB4;POLR3B;RGN;PTGESL;ADO
Carbon metabolismGPR19;GLUD1A;TPI1B;PFKP;IDH3G;ACADS;PKM2;ESD;HADHA
Biosynthesis of amino acidsPFKL;PFKM;PFKP;IDH3G;GLULA;PGK2;RPIA;ASS1;GPT2L

ALDOAB has several biochemical functions, for example, catalytic activity, fructose-bisphosphate aldolase activity, lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDOAB itself. We selected most functions ALDOAB had, and list some proteins which have the same functions with ALDOAB. You can find most of the proteins on our site.

Function Related Protein
catalytic activityPGGT1B;DIP2C;CWF19L2;AOAH;CKMT2B;ISOC2;PCYT1BB;TM9SF1;AGLA
fructose-bisphosphate aldolase activityALDOCA;ALDOA;ALDOCB;ALDOAA;ALDOAB;ALDOB;ALDOC
lyase activityCAR13;ADCY1A;ENO2;HOGA1;HMGB1;ADCY2B;CAHZ;TYW1;CAR3

ALDOAB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDOAB here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDOAB.

  • Q&As
  • Reviews

Q&As (18)

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Are there any known genetic mutations in ALDOAB? 01/23/2023

Yes, mutations in the ALDOAB gene are associated with hereditary fructose intolerance. These mutations lead to a deficiency in ALDOAB activity, resulting in the accumulation of fructose-1-phosphate and causing symptoms upon fructose consumption.

Is ALDOAB associated with any diseases? 06/11/2022

Yes, mutations in the ALDOAB gene are associated with a rare genetic disorder called hereditary fructose intolerance. This condition leads to a deficiency in ALDOAB activity, resulting in the inability to fully metabolize fructose and leading to severe symptoms upon fructose consumption.

Can ALDOAB be a potential therapeutic target? 02/08/2022

While ALDOAB deficiency is linked to hereditary fructose intolerance, there is currently no therapeutic intervention targeting this specific enzyme. However, managing the condition involves a strict fructose-free diet.

How is ALDOAB deficiency diagnosed? 02/11/2021

ALDOAB deficiency is typically diagnosed through genetic testing. This involves analyzing the ALDOAB gene for mutations or variations that can lead to reduced or absent enzyme activity. Additionally, blood tests can be performed to measure the levels of fructose-1-phosphate, which is typically elevated in individuals with hereditary fructose intolerance.

How is hereditary fructose intolerance treated? 01/24/2021

The primary treatment for hereditary fructose intolerance is the complete elimination of fructose, sucrose, and sorbitol from the diet. This includes avoiding fruits, fruit juices, honey, and foods with high levels of fructose and sucrose as ingredients. A registered dietitian can help create a suitable dietary plan.

Is there any research investigating the potential role of ALDOAB in cancer? 07/27/2020

Research on the potential role of ALDOAB in cancer is limited. However, some studies have suggested that altered fructose metabolism, for which ALDOAB is involved, may play a role in cancer progression and metabolism. Further research is needed to fully understand the significance of ALDOAB in cancer biology.

What are the symptoms of hereditary fructose intolerance? 06/23/2020

Symptoms of hereditary fructose intolerance can vary but commonly include gastrointestinal distress like abdominal pain, nausea, vomiting, and diarrhea after consuming fructose or foods and beverages containing fructose. Other symptoms may include low blood sugar levels, jaundice, liver dysfunction, and failure to thrive in infants.

Is ALDOAB being studied as a biomarker? 01/26/2020

ALDOAB is not typically studied as a biomarker, as its levels alone may not provide significant diagnostic or prognostic information. However, its deficiency can be diagnosed through genetic testing in individuals suspected of having hereditary fructose intolerance.

How is ALDOAB regulated in cells? 08/27/2019

ALDOAB expression is regulated at the gene transcription level, influenced by factors such as dietary fructose intake and hormonal regulation.

Is there a cure for ALDOAB deficiency? 08/27/2019

Currently, there is no cure for ALDOAB deficiency or hereditary fructose intolerance. However, the condition can be managed effectively through strict dietary modifications. Avoiding foods and beverages high in fructose, sucrose, and sorbitol can prevent symptoms and complications associated with the condition.

Can ALDOAB activity be modulated by drugs or other compounds? 08/16/2019

As of now, there are no known drugs or compounds specifically targeting ALDOAB activity. However, given the potential metabolic implications of altered fructose metabolism, it is an area of interest for potential therapeutic interventions in the future.

Is ALDOAB an essential enzyme for overall metabolism? 07/23/2019

While ALDOAB is not considered essential for overall metabolism, its deficiency in hereditary fructose intolerance can lead to significant health issues. In individuals without hereditary fructose intolerance, other enzymes can compensate for ALDOAB's role in fructose metabolism.

Is ALDOAB present in other tissues apart from the liver? 03/26/2019

While ALDOAB is primarily found in the liver, it may be present in lower levels in other tissues as well. Some research suggests its expression in tissues such as the kidney, intestines, and pancreatic islets, albeit at lower levels compared to the liver.

Does ALDOAB have any other functions besides fructose metabolism? 11/18/2018

ALDOAB is primarily known for its role in fructose metabolism. However, some studies suggest that it may have non-glycolytic functions, including modulating cell signaling pathways and cellular stress responses, but further research is needed to fully understand these potential roles.

Can ALDOAB deficiency be diagnosed in adulthood? 10/15/2018

ALDOAB deficiency, or hereditary fructose intolerance, is typically diagnosed in childhood when fructose-containing foods are introduced into the diet. However, in some cases, individuals may not exhibit symptoms until later in life. Genetic testing can be done to confirm the diagnosis at any age.

Are there any known complications or long-term effects of ALDOAB deficiency? 06/28/2018

The primary complication of ALDOAB deficiency is hereditary fructose intolerance. If left untreated, this condition can lead to severe liver damage, resulting in liver failure. It can also cause growth retardation, malnutrition, and in rare cases, neurological issues. However, with proper management through dietary modifications, these complications can be minimized or avoided.

Can ALDOAB deficiency be inherited? 03/13/2018

Yes, ALDOAB deficiency, also known as hereditary fructose intolerance, is an autosomal recessive disorder, meaning both parents must carry a mutated ALDOAB gene and pass it on to their child for the disorder to develop. If only one parent carries the mutation, the child will be a carrier but will not have the deficiency.

Are there any alternative treatments for hereditary fructose intolerance? 03/19/2016

The main treatment for hereditary fructose intolerance is a strict diet that avoids fructose, sucrose, and sorbitol-containing foods and beverages. There are currently no alternative treatments, but research is ongoing to explore potential therapeutic options or interventions.

Customer Reviews (4)

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Reviews
07/10/2019

    I greatly appreciate their commitment to ensuring my research is a success.

    03/11/2019

      The ALDOAB Protein is a protein of exceptional quality that surpasses my expectations and fulfills all my experimental requirements.

      09/13/2018

        The ALDOAB Protein offers a wide range of applications, making it highly versatile for various experimental settings.

        04/28/2017

          Its purity and consistency are of the highest standards, allowing for precise and reliable results in my research endeavors.

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