ALKBH2
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Official Full Name
alkB, alkylation repair homolog 2 (E. coli)
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Overview
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 -
Synonyms
ALKBH2; alkB, alkylation repair homolog 2 (E. coli); alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; ABH2; MGC90512; 2OG Fe(II) oxy DC1; 9530023G02; ABH 2; alkB alkylation repair homolog 2; ALKB2_HUMAN; ALKBH2 alkB; Alkylated DNA repair protein alkB homolog; Alkylated DNA repair protein alkB homolog 2; Alkylation repair homolog 2; Alpha ketoglutarate dependent dioxygenase alkB homolog 2; AU016977; EC 1.14.11.; FLJ99103; hABH2; mABH2; Oxy DC1; 2OG-Fe(II) oxy DC1; OTTHUMP00000240521; OTTHUMP00000240522;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
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- Rhesus Macaque
- Zebrafish
- E.coli
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- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ALKBH2 Related Articles
ALKBH2 involved in several pathways and played different roles in them. We selected most pathways ALKBH2 participated on our site, such as ALKBH2 mediated reversal of alkylation damage, DNA Damage Reversal, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ALKBH2 mediated reversal of alkylation damage | |
| DNA Damage Reversal | ALKBH3;ASCC3;MGMT;ALKBH2;ASCC1;ASCC2 |
| DNA Repair | ZBTB32;PPP4R2B;EYA4;RBBP8;DTL;NFRKB;KDM4B;CETN2;EME1 |
| Reversal of alkylation damage by DNA dioxygenases | ALKBH3;ASCC1;ASCC2;ASCC3;ALKBH2 |
ALKBH2 has several biochemical functions, for example, DNA-N1-methyladenine dioxygenase activity, cytosine C-5 DNA demethylase activity, ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH2 itself. We selected most functions ALKBH2 had, and list some proteins which have the same functions with ALKBH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-N1-methyladenine dioxygenase activity | FTO;PHF2;JMJD1C;KDM5BB;ALKBH3;ALKBH2;KDM5D |
| cytosine C-5 DNA demethylase activity | ALKBH2;ALKBH3 |
| ferrous iron binding | ACP5;EGLN2;ALKBH1;UROD;TF;HEPH;ALKBH2;BCO1;CDO1 |
ALKBH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH2.
ssdna_dadts; Nedd1; Sesn2; FERMT3; SLX4; Kif19
- Q&As
- Reviews
Q&As (18)
Ask a questionThe functional regulation of ALKBH2 may be affected by epigenetic changes, such as histone modification and DNA methylation.
Mutations in ALKBH2 may affect the development of embryos and lead to related diseases.
ALKBH2 is involved in biological processes such as double-stranded DNA repair and cell cycle control.
ALKBH2 plays an important role in the DNA demethylation pathway and is involved in a number of DNA repair related pathways.
ALKBH2 interacts with a series of DNA repair related proteins such as DNA methyltransferase and DNA repair activator to participate in DNA repair.
ALKBH2 gene contains 10 exons and its expression is influenced by several regulatory elements and signaling pathways.
The activity of ALKBH2 may be regulated and interfered with by some chemicals, but the specific mechanism of action needs further study.
It is mainly used to modify DNA, but it also has some ability to modify RNA.
Overexpression or knockout of ALKBH2 can lead to incomplete repair of DNA damage and affect cell proliferation and division.
ALKBH2 is mainly found in the nucleus and is involved in biological processes such as DNA repair.
ALKBH2 removes methyl groups from DNA bases and is involved in DNA repair and cell proliferation.
This protein plays an important role in a variety of tumors, such as colorectal cancer, small cell lung cancer and so on.
A number of inhibitors have been developed that target ALKBH2 and inhibit its ability to acquire DNA methylation repair.
It is involved in multiple DNA single and double strand damage repair pathways, including light damage repair pathways.
Current research data show that ALKBH2 is associated with gene transcription, but the specific mechanism of action remains to be explored.
Mutations in ALKBH2 have been linked to some DNA repair related diseases and cancers.
It plays an important role in several neurological diseases, such as neurodegenerative diseases and Parkinson's disease.
ALKBH2 is involved in biological processes such as DNA repair, cell proliferation and differentiation.
Customer Reviews (5)
Write a reviewExhibited the expected biological activities, such as enzymatic activity and receptor binding activity.
ALKBH2 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.
Good crystallization properties when analyzed by X-ray crystallography or other crystallization techniques.
The products are reliable and stable, and are widely used in scientific research, industrial production and medical fields.
The purity of ALKBH2 was good and the results obtained after analysis by SDS-PAGE or Western blot were excellent.
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