Alox12
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Official Full Name
arachidonate 12-lipoxygenase
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Overview
Arachidonate 12-lipoxygenase, 12S-type is an enzyme that in humans is encoded by the ALOX12 gene. -
Synonyms
ALOX12; arachidonate 12-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; 12S-type; 12 Lox; 12(S) lipoxygenase; 12S LOX; 12S-lipoxygenase; 12S-LOX; Alox 12; Alox12L; Alox15; Arachidonate 12 lipoxygenase 12S type; Arachidonate 12 lipoxygenase; Arachidonate 12 lipoxygenase leukocyte type; Arachidonate 12 lipoxygenase, 12S type; Arachidonate 12 lipoxygenase, leukocyte type; EC1.13.11.31; LOG 12; LOG12; LOX12_HUMAN; Platelet type 12 lipoxygenase; Platelet type lipoxygenase 12; Platelet-type lipoxygenase 12; P-12LO; Alox12p; 9930022G08Rik;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect cell
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
Alox12 involved in several pathways and played different roles in them. We selected most pathways Alox12 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Alox12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arachidonic acid metabolism | CYP2V1;CBR3;DPEP2;CYP4A12A;PTGES3A;CYP2J2;CYP2P9;AWAT1;PLA2G2F |
Metabolic pathways | AKR1C4;IMPDH2;DGAT1;GART;NT5C3A;ALDH5A1;PISD;ATP6V0E2;GAL3ST1A |
Serotonergic synapse | PRKACB;GNG8;CYP2C70;MAOA;HTR5A;PLCB3;GNG5;SLC18A2;GNGT1 |
Inflammatory mediator regulation of TRP channels | MAP2K6;PIK3CD;F2RL1;CALML3;PRKCA;HTR2C;MAPK12;P2RY2;CYP2J6 |
Alox12 has several biochemical functions, for example, arachidonate 12-lipoxygenase activity, hepoxilin A3 synthase activity, hepoxilin-epoxide hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Alox12 itself. We selected most functions Alox12 had, and list some proteins which have the same functions with Alox12. You can find most of the proteins on our site.
Function | Related Protein |
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arachidonate 12-lipoxygenase activity | ALOX12;ALOX15;ALOX12E;ALOX12B |
hepoxilin A3 synthase activity | ALOX15;ALOX12 |
hepoxilin-epoxide hydrolase activity | ALOX15;ALOX12 |
iron ion binding | CYP2AD2;HBB-BH1;CYP8B3;CYP4A11;HBE;BBOX1;EGLN1B;NFU1;CYP2AA12 |
linoleate 13S-lipoxygenase activity | ALOX15B;ALOX8;ALOX12 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ADOA;P4HA1;P4HA1B;ALOX5B.3;TMLHE;BCO2;ALOX5A;ALOX5B.2;ALOX8 |
protein binding | EFEMP1;GPR85;ETV1;PRKCB;NLGN4Y;ADM;GAS6;NBN;ZNF410 |
Alox12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Alox12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Alox12.
KRT5; LMNA; PLA2G2A; ITGB4; TRIB1
- Q&As
- Reviews
Q&As (13)
Ask a questionIt is involved in the pathological process of virus-induced hepatitis, which may be related to virus clearance and liver disease recovery.
This is associated with some signaling pathways, such as PI3K/AKT pathway and MAPK pathway.
ALOX12 is involved in several biological processes associated with obesity, such as adipocyte differentiation, glucose and lipid metabolism.
ALOX12 is involved in the occurrence and development of a variety of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.
ALOX12 is involved in endothelial cell function impairment and is associated with diabetic complications.
This is a membrane binding protein with a core membrane binding domain and an extramembrane catalytic domain.
The oxidizes linolenic acid to produce 12S-LOX and 15S-LOX metabolites by oxygenation.
This protein is mainly involved in the metabolic pathway of linolenic acid, catalyzing the synthesis of 12S-LOX and 15S-LOX metabolites.
ALOX12 catalyzes linolenic acid to produce 12S-LOX and 15S-LOX metabolites, which have biological activities, including participating in inflammatory responses, regulating platelet activation, and regulating T cell function.
It is expressed in a variety of tissues in the human body, such as the skin, heart, lungs, liver, kidneys, intestines, and nervous system.
The human ALOX12 gene has a variety of variants, including SNP and InDel, that can lead to its dysfunction or increased risk.
ALOX12 is involved in the process of myocardial cell damage after myocardial infarction, which may be related to myocardial regeneration and repair.
ALOX12 is believed to be associated with a variety of diseases, such as cancer, inflammation, neurodegenerative diseases, cardiovascular disease, and more.
Customer Reviews (4)
Write a reviewIt has good efficacy and high safety as an immunotherapy drug.
ALOX12 has a good inhibitory effect on cell proliferation and survival.
There is no interaction or influence with other drugs.
Functionally enhanced or altered by protein modification techniques.
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