Alox8
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Official Full Name
arachidonate 8-lipoxygenase
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Synonyms
ALOX8;arachidonate 8-lipoxygenase;ENSMUSG00000020891;8-LOX;8S-LOX;Alox15b;11;11 B4;arachidonate 15-lipoxygenase B;arachidonate 15-lipoxygenase B;15-LOX-2;15-LOX-B;8S-lipoxygenase;15-lipoxygenase 2;arachidonate 15-lipoxygenase type II;arachidonate 15-lipoxygenase, second type;EC 1.13.11.33;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Mouse | ALOX8-1569M | Recombinant Mouse ALOX8 Protein | Mammalian Cell | His | ||
Mouse | ALOX8-485M | Recombinant Mouse ALOX8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ALOX8-485M-B | Recombinant Mouse ALOX8 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- Alox8 Related Articles
Alox8 involved in several pathways and played different roles in them. We selected most pathways Alox8 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Alox8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arachidonic acid metabolism | CBR2;GPX1A;PLA2G4AA;CYP4A11;EPHX2;GPX8;CYP2P7;PLA2G4F;CYP4F18 |
Metabolic pathways | ACSL4;ACADSB;KMO;FUT7;AMY2A4;COQ3;PCYT1A;AMPD2;ATP6V0C |
Serotonergic synapse | PLA2G4D;HTR6;TPH1;CYP2C38;MAPK3;ALOX5;ALOX12;ALOX12E;KCND2 |
Alox8 has several biochemical functions, for example, 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity, 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity, 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Alox8 itself. We selected most functions Alox8 had, and list some proteins which have the same functions with Alox8. You can find most of the proteins on our site.
Function | Related Protein |
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1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity | |
1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity | |
1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity | |
1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity | |
2-aminobiphenyl-2,3-diol 1,2-dioxygenase activity | |
2,2,3-trihydroxybiphenyl dioxygenase activity | |
2,3-dihydroxy DDT 1,2-dioxygenase activity | |
2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity | |
2,3-dihydroxy-p-cumate dioxygenase activity | |
2,3-dihydroxydiphenyl ether dioxygenase activity | |
2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity | |
2-aminophenol 1,6-dioxygenase activity | |
2-mercaptobenzothiazole dioxygenase activity | |
3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity | |
3,4-dihydroxyphenanthrene dioxygenase activity | |
3,5-dichlorocatechol 1,2-dioxygenase activity | |
3-hydroxy-2-naphthoate 2,3-dioxygenase activity | |
4,5-dihydroxybenzo(a)pyrene dioxygenase activity | |
4,5-dihydroxypyrene dioxygenase activity | |
4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity | |
4-hydroxycatechol 1,2-dioxygenase activity | |
5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity | |
5-aminosalicylate dioxygenase activity | |
7,8-dihydroxy benzo(a)pyrene dioxygenase activity | |
9,10-dihydroxybenzo(a)pyrene dioxygenase activity | |
arachidonate 15-lipoxygenase activity | ALOX15B;ALOX8;ALOX15 |
arachidonate 8(R)-lipoxygenase activity | |
arachidonate 8(S)-lipoxygenase activity | ALOX8;ALOX15B |
benzo(a)pyrene 11,12-dioxygenase activity | |
benzo(a)pyrene 4,5-dioxygenase activity | |
benzo(a)pyrene 7,8-dioxygenase activity | |
benzo(a)pyrene 9,10-dioxygenase activity | |
calcium ion binding | NOTCH1;FBLN7;SYT5B;MCTP1;RAB11FIP3;ACTN3;PCDHB12;PCDH1G31;BGLAP-RS1 |
carbazole 1,9a-dioxygenase activity | |
catechol dioxygenase activity | |
chlorocatechol 1,2-dioxygenase activity | |
dihydroxydibenzothiophene dioxygenase activity | |
dihydroxyfluorene dioxygenase activity | |
dioxygenase activity | ALOX8;BCO2L;ASPHD1;ADOA;KDM3B;PHYHD1;ALOX12E;ALOX5B.2;ALKBH6 |
diphenyl ether 1,2-dioxygenase activity | |
hydroquinone 1,2-dioxygenase activity | |
iron ion binding | CYP2K6;JHDM1D;CYP4F12;P4HA1B;CYP2A12;CYP46A1.2;HBZ;CYP2C38;XDH |
linoleate 13S-lipoxygenase activity | ALOX12;ALOX15B;ALOX8 |
lipid binding | PTEN;CADPS;FAM123C;DBIL5;FABP11B;ALOX8;BPIFB6;ATP5G3;EPN1 |
metal ion binding | ZNF669;CSNK2B;ZFP13;ZMYND19;ACAP3;PITPNM1;IKZF1;CHN1;NT5DC3 |
oxidoreductase activity | NOS2B;CYP2AA7;ALDH2.2;PHF2;AOC1;AKR1E1;ADOB;CYP2AD6;PRODH2 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | TMLHE;ALOX5A;ADOA;ALOX5B.3;P4HA1B;P4HA2;BCO2;ALOX12;ADOB |
p-cumate 2,3-dioxygenase activity | |
phenanthrene dioxygenase activity | |
phenanthrene-4-carboxylate dioxygenase activity | |
protocatechuate 3,4-dioxygenase type II activity | |
pyrene dioxygenase activity | |
pyridine-3,4-diol dioxygenase activity | |
styrene dioxygenase activity | |
tetrachlorobenzene dioxygenase activity |
Alox8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Alox8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Alox8.
- Q&As
- Reviews
Q&As (15)
Ask a questionThis gene is regulated by a variety of factors, including nutrients and hormones.
The ALOX8 gene is associated with genes related to the 5-LOX pathway of white blood cells such as CYSLTR1 and CYSLTR2.
Mutations in the ALOX8 gene have been linked to respiratory diseases such as asthma and nasal polyps.
The expression of ALOX8 gene is regulated by NF-κB, AP-1 and other transcription factors.
This gene may play an important role in tumorigenesis and development and may be a potential tumor suppressor gene.
The ALOX8 gene is involved in the leukocyte 5-LOX pathway, which influences leukocyte infiltration and inflammatory response.
The expression of ALOX8 gene may be regulated by ATP level.
ALOX8 gene is involved in chemotaxis and migration of monocytes and may play a role in immune response.
ALOX8 gene is involved in arachidonic acid metabolism, affects leukocyte infiltration and inflammatory response, and may have a certain impact on neurotransmitter synthesis.
The gene is involved in arachidonic acid metabolism, which affects leukocyte infiltration and inflammatory response.
ALOX8 gene polymorphism may be associated with respiratory diseases such as asthma and nasal polyps.
The ALOX8 gene encodes the protein 5-LOX (5-lipoxygenase).
The ALOX8 gene is mainly expressed in white blood cells and is expressed at low levels in a variety of tissues.
The ALOX8 gene is involved in the pathogenesis of diseases such as asthma and chronic obstructive pulmonary disease.
The expression of ALOX8 gene may be affected by external environment such as oxygen concentration and oxidative stress.
Customer Reviews (3)
Write a reviewCatalytic activity is very strong, and it can perform excellent catalysis even at low concentrations, showing excellent catalytic performance.
High purity can reduce the interference of impurities in the experiment and improve the accuracy of the experiment.
The yield was high and the purity was high, which facilitated our large-scale experiments.
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