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Alox8

  • Official Full Name

    arachidonate 8-lipoxygenase

  • Synonyms

    ALOX8;arachidonate 8-lipoxygenase;ENSMUSG00000020891;8-LOX;8S-LOX;Alox15b;11;11 B4;arachidonate 15-lipoxygenase B;arachidonate 15-lipoxygenase B;15-LOX-2;15-LOX-B;8S-lipoxygenase;15-lipoxygenase 2;arachidonate 15-lipoxygenase type II;arachidonate 15-lipoxygenase, second type;EC 1.13.11.33;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse ALOX8-1569M Recombinant Mouse ALOX8 Protein Mammalian Cell His
Mouse ALOX8-485M Recombinant Mouse ALOX8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALOX8-485M-B Recombinant Mouse ALOX8 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Alox8 Related Articles

Alox8 involved in several pathways and played different roles in them. We selected most pathways Alox8 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Alox8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismCBR2;GPX1A;PLA2G4AA;CYP4A11;EPHX2;GPX8;CYP2P7;PLA2G4F;CYP4F18
Metabolic pathwaysACSL4;ACADSB;KMO;FUT7;AMY2A4;COQ3;PCYT1A;AMPD2;ATP6V0C
Serotonergic synapsePLA2G4D;HTR6;TPH1;CYP2C38;MAPK3;ALOX5;ALOX12;ALOX12E;KCND2

Alox8 has several biochemical functions, for example, 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity, 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity, 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Alox8 itself. We selected most functions Alox8 had, and list some proteins which have the same functions with Alox8. You can find most of the proteins on our site.

Function Related Protein
1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity
1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity
1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
2-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
2,2,3-trihydroxybiphenyl dioxygenase activity
2,3-dihydroxy DDT 1,2-dioxygenase activity
2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
2,3-dihydroxy-p-cumate dioxygenase activity
2,3-dihydroxydiphenyl ether dioxygenase activity
2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
2-aminophenol 1,6-dioxygenase activity
2-mercaptobenzothiazole dioxygenase activity
3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity
3,4-dihydroxyphenanthrene dioxygenase activity
3,5-dichlorocatechol 1,2-dioxygenase activity
3-hydroxy-2-naphthoate 2,3-dioxygenase activity
4,5-dihydroxybenzo(a)pyrene dioxygenase activity
4,5-dihydroxypyrene dioxygenase activity
4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity
4-hydroxycatechol 1,2-dioxygenase activity
5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
5-aminosalicylate dioxygenase activity
7,8-dihydroxy benzo(a)pyrene dioxygenase activity
9,10-dihydroxybenzo(a)pyrene dioxygenase activity
arachidonate 15-lipoxygenase activityALOX15B;ALOX8;ALOX15
arachidonate 8(R)-lipoxygenase activity
arachidonate 8(S)-lipoxygenase activityALOX8;ALOX15B
benzo(a)pyrene 11,12-dioxygenase activity
benzo(a)pyrene 4,5-dioxygenase activity
benzo(a)pyrene 7,8-dioxygenase activity
benzo(a)pyrene 9,10-dioxygenase activity
calcium ion bindingNOTCH1;FBLN7;SYT5B;MCTP1;RAB11FIP3;ACTN3;PCDHB12;PCDH1G31;BGLAP-RS1
carbazole 1,9a-dioxygenase activity
catechol dioxygenase activity
chlorocatechol 1,2-dioxygenase activity
dihydroxydibenzothiophene dioxygenase activity
dihydroxyfluorene dioxygenase activity
dioxygenase activityALOX8;BCO2L;ASPHD1;ADOA;KDM3B;PHYHD1;ALOX12E;ALOX5B.2;ALKBH6
diphenyl ether 1,2-dioxygenase activity
hydroquinone 1,2-dioxygenase activity
iron ion bindingCYP2K6;JHDM1D;CYP4F12;P4HA1B;CYP2A12;CYP46A1.2;HBZ;CYP2C38;XDH
linoleate 13S-lipoxygenase activityALOX12;ALOX15B;ALOX8
lipid bindingPTEN;CADPS;FAM123C;DBIL5;FABP11B;ALOX8;BPIFB6;ATP5G3;EPN1
metal ion bindingZNF669;CSNK2B;ZFP13;ZMYND19;ACAP3;PITPNM1;IKZF1;CHN1;NT5DC3
oxidoreductase activityNOS2B;CYP2AA7;ALDH2.2;PHF2;AOC1;AKR1E1;ADOB;CYP2AD6;PRODH2
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenTMLHE;ALOX5A;ADOA;ALOX5B.3;P4HA1B;P4HA2;BCO2;ALOX12;ADOB
p-cumate 2,3-dioxygenase activity
phenanthrene dioxygenase activity
phenanthrene-4-carboxylate dioxygenase activity
protocatechuate 3,4-dioxygenase type II activity
pyrene dioxygenase activity
pyridine-3,4-diol dioxygenase activity
styrene dioxygenase activity
tetrachlorobenzene dioxygenase activity

Alox8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Alox8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Alox8.

Kawajiri, H; Piao, YS; et al. Synthesis of 8,9-leukotriene A(4) by murine 8-lipoxygenase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 338:144-148(2005).
Furstenberger, G; Marks, F; et al. Arachidonate 8(S)-lipoxygenase. PROSTAGLANDINS & OTHER LIPID MEDIATORS 68-9:235-243(2002).
  • Q&As
  • Reviews

Q&As (15)

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What factors regulate the ALOX8 gene? 02/12/2023

This gene is regulated by a variety of factors, including nutrients and hormones.

What other genes is the ALOX8 gene associated with? 01/30/2023

The ALOX8 gene is associated with genes related to the 5-LOX pathway of white blood cells such as CYSLTR1 and CYSLTR2.

Which diseases are linked to mutations in the ALOX8 gene? 11/02/2022

Mutations in the ALOX8 gene have been linked to respiratory diseases such as asthma and nasal polyps.

Which transcription factors regulate the expression of ALOX8 gene? 04/06/2022

The expression of ALOX8 gene is regulated by NF-κB, AP-1 and other transcription factors.

What does the ALOX8 gene have to do with tumors? 12/24/2021

This gene may play an important role in tumorigenesis and development and may be a potential tumor suppressor gene.

Which signaling pathways are involved in the ALOX8 gene? 11/04/2021

The ALOX8 gene is involved in the leukocyte 5-LOX pathway, which influences leukocyte infiltration and inflammatory response.

Which ATP levels are affected by the ALOX8 gene? 09/27/2021

The expression of ALOX8 gene may be regulated by ATP level.

What immune response is the ALOX8 gene involved in? 12/23/2020

ALOX8 gene is involved in chemotaxis and migration of monocytes and may play a role in immune response.

What is the effect of ALOX8 gene on neurotransmitter synthesis? 12/13/2020

ALOX8 gene is involved in arachidonic acid metabolism, affects leukocyte infiltration and inflammatory response, and may have a certain impact on neurotransmitter synthesis.

What biological processes is the ALOX8 gene involved in? 08/13/2020

The gene is involved in arachidonic acid metabolism, which affects leukocyte infiltration and inflammatory response.

What diseases are polymorphisms in the ALOX8 gene associated with? 06/22/2020

ALOX8 gene polymorphism may be associated with respiratory diseases such as asthma and nasal polyps.

What is the protein encoded by the ALOX8 gene? 04/22/2020

The ALOX8 gene encodes the protein 5-LOX (5-lipoxygenase).

What is the expression pattern of ALOX8 gene? 04/21/2020

The ALOX8 gene is mainly expressed in white blood cells and is expressed at low levels in a variety of tissues.

In what diseases is the ALOX8 gene involved? 12/01/2019

The ALOX8 gene is involved in the pathogenesis of diseases such as asthma and chronic obstructive pulmonary disease.

What external environment influences the expression of ALOX8 gene? 09/23/2019

The expression of ALOX8 gene may be affected by external environment such as oxygen concentration and oxidative stress.

Customer Reviews (3)

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Reviews
12/11/2020

    Catalytic activity is very strong, and it can perform excellent catalysis even at low concentrations, showing excellent catalytic performance.

    09/06/2020

      High purity can reduce the interference of impurities in the experiment and improve the accuracy of the experiment.

      12/15/2019

        The yield was high and the purity was high, which facilitated our large-scale experiments.

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