ALPK2
-
Official Full Name
alpha-kinase 2
-
Synonyms
ALPK2; alpha-kinase 2; alpha-protein kinase 2; HAK; heart alpha kinase; heart alpha-kinase; heart alpha-protein kinase; FLJ34875; FLJ43253;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ALPK2-492H | Recombinant Human ALPK2 Protein, GST-tagged | Wheat Germ | GST |
|
|
| Mouse | ALPK2-1573M | Recombinant Mouse ALPK2 Protein | Mammalian Cell | His |
|
|
| Mouse | ALPK2-486M-B | Recombinant Mouse ALPK2 Protein Pre-coupled Magnetic Beads | HEK293 |
|
||
| Mouse | ALPK2-486M | Recombinant Mouse ALPK2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
|
- Involved Pathway
- Protein Function
- Interacting Protein
ALPK2 involved in several pathways and played different roles in them. We selected most pathways ALPK2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALPK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ALPK2 has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase activity, AMP-activated protein kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALPK2 itself. We selected most functions ALPK2 had, and list some proteins which have the same functions with ALPK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-phosphoinositide-dependent protein kinase activity | ALPK2;PDPK1 |
| AMP-activated protein kinase activity | PRKAA2;PRKAA1;PRKAB1;ALPK2;PRKAG2;PRKAG3 |
| ATP binding | ATP2A2A;MYO1D;DAK;MTHFD1L;MYO10;DNAJA2;DGKG;ZAK;RBKS |
| DNA-dependent protein kinase activity | XRCC6BP1;ATM;HMGA2;ALPK2;PRKDC |
| GTP-dependent protein kinase activity | ALPK2;LRRK2 |
| JUN kinase activity | MAPK10;ALPK2;MAPK9;MAPK8 |
| JUN kinase kinase activity | MAP2K4A;ALPK2;MAP2K4B |
| JUN kinase kinase kinase activity | ALPK2;MAP3K9;MAP3K1;MAP3K10;MAP3K11 |
| MAP kinase kinase activity | MAP2K3;PAK3;MAP2K2A;MAP2K2B;LRRK2;MAP2K2;MAP3K9;MAP3K14;MAPKAPK5 |
| MAP kinase kinase kinase activity | STK4;TAOK1;EGFR;MAP3K14;TAOK2;MAP3K6;MAP3K5;MAP3K4;STK3 |
| MAP kinase kinase kinase kinase activity | MAP4K1;ALPK2;MAP4K3;MAP4K2;MAP4K6;MAP4K5 |
| NF-kappaB-inducing kinase activity | PPP4C;ALK;RIPK3;IRAK1;IKBKE;MAP3K14;ALPK2 |
| SAP kinase activity | |
| calcium-dependent protein kinase C activity | ALPK2;PRKCG;CCL3;PRKCA |
| cyclic nucleotide-dependent protein kinase activity | |
| cyclin-dependent protein kinase activating kinase activity | ALPK2;CDKN1A |
| eukaryotic translation initiation factor 2alpha kinase activity | EIF2AK1;ALPK2;EIF2AK4;EIF2AK2;EIF2AK3 |
| kinase activity | FGGY;PKN2;PDXKB;RPS6KAL;TPK1;PRKACBB;PINK1;CAMK2B1;BSK146 |
| molecular_function | TIGD3;PPP1R8B;ATG2A;TMEM151B;JRK;SDR42E1;ZNF24;LRRC66;RPZ4 |
| protein serine/threonine kinase activity | ADCK2;SLC14A2;GM711;CLK3;ROCK2A;AKT1;SGK1;PRKACBB;CLK4 |
| receptor signaling protein serine/threonine kinase activity | TGFBR1B;AMHR2;STK25A;ACVRL1;STK26;ACVR1;BMPR2A;ACVR1B;PAK2B |
| ribosomal protein S6 kinase activity | RPS6KA3B;RPS6KA3A;RPS6KB2;RPS6KA2;RPS6KA6;RPS6KB1B;RPS6KA1;RPS6KB1;ALPK2 |
| transferase activity | ACVR1L;FUT9D;GRK7B;PKDCCA;CAMK2D1;4931440L10Rik;WNK2;UGT1B7;DNMT3AA |
| transmembrane receptor protein kinase activity | |
| transmembrane receptor protein serine/threonine kinase activity | ACVRL1;BMPR1B;ALPK2;BMPR2B;ACVR2AA;BMPR1BB;BMPR1AB;TGFBR1B;BMPR1BA |
ALPK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALPK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALPK2.
- Q&As
- Reviews
Q&As (10)
Ask a questionALPK2 is predominantly expressed in cardiac and skeletal muscle tissues, with lower expression levels observed in other tissues.
ALPK2 can potentially be targeted pharmacologically using specific inhibitors or activators to modulate its activity and downstream signaling pathways.
Mutations in ALPK2 can disrupt its kinase activity and alter downstream signaling pathways, leading to pathological conditions.
The mechanisms underlying ALPK2-mediated signal transduction involve complex intracellular signaling cascades, including protein phosphorylation, calcium signaling, and gene expression regulation.
Dysregulation of ALPK2 is associated with various cardiovascular diseases, including cardiomyopathies and arrhythmias, as well as genetic disorders such as familial cardiomyopathy.
ALPK2 is critical for proper cardiac function and cardiovascular development, and its dysregulation can lead to various cardiac disorders.
ALPK2 has several known substrates and downstream effectors involved in calcium handling, sarcomere organization, and signal transduction.
ALPK2 can interact with other proteins, such as ion channels, scaffolding proteins, and signaling molecules, forming protein complexes that modulate its activity and signaling specificity.
ALPK2 is involved in regulating cell cycle progression, apoptosis, and DNA damage response in specific cellular contexts, contributing to cellular homeostasis and disease development.
ALPK2 is implicated in the regulation of calcium homeostasis and ion channel function, particularly in cardiac muscle cells.
Customer Reviews (3)
Write a reviewExcellent crystal quality improvement in crystallization.
Accurate protein biomarker quantification in clinical samples.
Sensitive bioactivity assay performance.
Ask a Question for All ALPK2 Products
Required fields are marked with *
My Review for All ALPK2 Products
Required fields are marked with *
