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ALMS1

  • Official Full Name

    Alstrom syndrome 1

  • Overview

    This gene encodes a protein containing a large tandem-repeat domain. The mouse ortholog of this gene has been shown to function in ciliogenesis in inner medullary collecting duct cells. Mutations in this gene have been associated with Alstrom syndrome. Alternative splice variants have been described but their full length sequences have not been determined.
  • Synonyms

    ALMS1; Alstrom syndrome 1; Alstrom syndrome protein 1; KIAA0328; ALSS; DKFZp686A118; DKFZp686D1828;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALMS1-301491H Recombinant Human ALMS1 protein, GST-tagged E.coli GST Leu2881-His3000
Mouse ALMS1-1562M Recombinant Mouse ALMS1 Protein Mammalian Cell His
Mouse ALMS1-480M-B Recombinant Mouse ALMS1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ALMS1-480M Recombinant Mouse ALMS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ALMS1 involved in several pathways and played different roles in them. We selected most pathways ALMS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALMS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ALMS1 has several biochemical functions, for example, alpha-actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALMS1 itself. We selected most functions ALMS1 had, and list some proteins which have the same functions with ALMS1. You can find most of the proteins on our site.

Function Related Protein
alpha-actinin bindingXIRP2;MAGI1;ALMS1;RARA;PKD2L1;DAG1;ADORA2A;LRRC10;KCNA5

ALMS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALMS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALMS1.

Atp6v1a

  • Q&As
  • Reviews

Q&As (14)

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In which tissues and organs is ALMS1 gene expressed? 01/19/2023

The ALMS1 gene is expressed in several tissues and organs, including the retina, cerebral cortex, small intestine, kidney, and pancreas.

How is Alstrom syndrome inherited? 10/01/2022

Alstrom syndrome is an autosomal recessive disorder caused by a mutation in the ALMS1 gene.

Which cancers are linked to mutations in the ALMS1 gene? 06/24/2022

No studies have shown that ALMS1 mutations are associated with cancer.

How does ALMS1 mutation affect protein function? 02/11/2022

Mutations in the ALMS1 gene may lead to changes in the structure or function of the ALMS1 protein, which may affect its role in the cell as well as the metabolism and signaling processes of the entire cell.

What are the symptoms of Alstrom syndrome that are currently treated? 11/27/2021

There are treatments that address the symptoms of Alstrom syndrome, including vision rehabilitation training, diabetes treatment, and hearing tests.

What does the ALMS1 gene code for? 04/19/2021

The ALMS1 gene encodes the ALMS1 protein, the function of which is not fully understood.

Is there any research on the role of ALMS1 gene in nervous system development? 03/28/2021

Yes, some research suggests that the ALMS1 gene may also have a role in nervous system development.

Are ALMS1 mutations diverse? 01/26/2021

Yes, there is a great diversity of ALMS1 mutations.

Is ALMS1 gene mutation associated with congenital heart disease? 01/19/2021

There are few studies on the relationship between ALMS1 gene mutation and congenital heart disease, and there is no clear conclusion at present.

Are there any studies showing that ALMS1 gene mutations are associated with diseases related to the immune system? 03/01/2020

Some studies suggest that ALMS1 gene mutations may be associated with autoimmune diseases, rheumatoid arthritis, etc.

Does the ALMS1 gene mutation affect people's intelligence? 01/07/2020

Mutations in the ALMS1 gene may affect intellectual development, but the extent of the effect is less certain.

Is there a gene therapy method for ALMS1 gene mutation? 11/18/2019

There is currently no gene therapy for the ALMS1 gene mutation.

What symptoms and diseases do mutations in the ALMS1 gene cause? 09/04/2019

Mutations in the ALMS1 gene can cause Alstrom syndrome, which has symptoms including early blindness, obesity, diabetes, deafness and more.

Can the ALMS1 gene mutation be passed on to the next generation? 08/14/2019

Yes, because Alstrom syndrome is an autosomal recessive disorder, the ALMS1 gene mutation may be passed on to the next generation.

Customer Reviews (4)

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Reviews
07/24/2022

    Good stability under different temperature and humidity conditions.

    06/19/2022

      The effect of chemical modification, such as PEGylation or glycosylation, is small.

      03/27/2020

        Accurate localization and function in cells.

        07/24/2019

          ALMS1 was effective in removing impurities during purification.

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