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AMBRA1

  • Official Full Name

    autophagy/beclin-1 regulator 1

  • Synonyms

    AMBRA1; autophagy/beclin-1 regulator 1; activating molecule in BECN1-regulated autophagy protein 1; DCAF3; DDB1 and CUL4 associated factor 3; FLJ20294; KIAA1736; WD repeat domain 94; WDR94; activating molecule in beclin-1-regulated autophagy; MGC33725;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AMBRA1-9609H Recombinant Human AMBRA1 protein, His-tagged E.coli His 906-1208 aa
Human AMBRA1-8887HCL Recombinant Human AMBRA1 293 Cell Lysate HEK293 N/A
Human AMBRA1-332H Recombinant Human AMBRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AMBRA1-5951H Recombinant Human AMBRA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AMBRA1-1736HFL Recombinant Full Length Human AMBRA1 Protein, C-Flag-tagged Mammalian cells Flag
Human AMBRA1-01H Active Recombinant Human AMBRA1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human AMBRA1-332H-B Recombinant Human AMBRA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse AMBRA1-1590M Recombinant Mouse AMBRA1 Protein Mammalian Cell His
Mouse Ambra1-3111M Recombinant Mouse Ambra1, His-tagged E.Coli or Yeast His 1209
Mouse AMBRA1-501M-B Recombinant Mouse AMBRA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ambra1-1608M Recombinant Mouse Ambra1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse AMBRA1-501M Recombinant Mouse AMBRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AMBRA1 Related Articles

AMBRA1 involved in several pathways and played different roles in them. We selected most pathways AMBRA1 participated on our site, such as Cellular responses to stress, Macroautophagy, Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMBRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular responses to stressNUPL2;RB1CC1;BMI1A;HIF1AL;GABARAP;UVRAG;SCMH1;H3F3D;RRAGB
MacroautophagyRB1CC1;MAP1LC3B;DYNLL2B;ATG9B;AMBRA1B;WDR45;WDR45L;ATG7;WIPI1
Senescence and AutophagyUVRAG;MAP1LC3C;LC3;GABARAP;IFI16;RB1CC1;ING1;IL24;SLC39A3

AMBRA1 has several biochemical functions, for example, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMBRA1 itself. We selected most functions AMBRA1 had, and list some proteins which have the same functions with AMBRA1. You can find most of the proteins on our site.

Function Related Protein
protein bindingVMP1;FTSJ3;ISOC1;DPM3;CREM;ASNS;KRT15;DDX11;SREK1
ubiquitin protein ligase bindingPML;HM13;CUL3A;ANKRD32;FBXW7;UBE2V2;UBE2KA;HSPA1B;EGR2

AMBRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMBRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AMBRA1.

BECN1; BCL2; vif

Men, RT; Wen, MY; et al. Nogo-B: A potential indicator for hepatic cirrhosis and regulator in hepatic stellate cell activation. HEPATOLOGY RESEARCH 45:113-122(2015).
Joseph, AM; Adhihetty, PJ; et al. Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (10)

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What are the post-translational modifications that regulate AMBRA1 function in autophagy? 11/26/2022

AMBRA1 undergoes post-translational modifications, including phosphorylation and ubiquitination, which regulate its interaction with other autophagy-related proteins and modulate its function in autophagy.

What role does AMBRA1 play in selective autophagy pathways, such as mitophagy and aggrephagy? 06/28/2022

AMBRA1 participates in selective autophagy processes, such as mitophagy (selective clearance of damaged mitochondria) and aggrephagy (clearance of protein aggregates), contributing to cellular quality control mechanisms.

What is the impact of AMBRA1 on autophagy regulation? 03/30/2021

AMBRA1 plays a critical role in autophagy regulation by promoting autophagosome formation, facilitating cargo recognition and degradation, and coordinating the activity of other autophagy-related proteins.

How does AMBRA1 influence the clearance of protein aggregates and damaged organelles through autophagy? 08/14/2020

AMBRA1 facilitates the clearance of protein aggregates and damaged organelles through autophagy, preventing their accumulation and mitigating cellular damage.

How is AMBRA1 expression regulated during autophagy induction? 01/14/2020

AMBRA1 expression is induced during autophagy by various signaling pathways, including nutrient deprivation, cellular stress, and growth factor signaling.

How does AMBRA1 interact with other cellular processes, such as apoptosis and cell proliferation, in coordination with autophagy? 12/18/2018

In addition to its role in autophagy, AMBRA1 interacts with other cellular processes, such as apoptosis and cell proliferation, forming intricate crosstalk that influences cellular fate and homeostasis.

How does AMBRA1 interact with Beclin 1, ULK1, and ATG proteins? 11/08/2018

AMBRA1 interacts with Beclin 1, ULK1, and ATG proteins through protein-protein interactions, forming complexes that regulate autophagy initiation and autophagosome formation.

What are the functional consequences of AMBRA1 depletion on autophagy activity? 11/03/2018

Depletion of AMBRA1 leads to impaired autophagy activity, resulting in the accumulation of damaged proteins and organelles and compromised cellular homeostasis.

How does AMBRA1 contribute to autophagosome formation and maturation? 04/19/2017

AMBRA1 promotes autophagosome formation by regulating the nucleation and elongation steps, ensuring proper assembly of the autophagy machinery and cargo sequestration.

What are the upstream signaling pathways that modulate AMBRA1 activity in autophagy? 02/18/2017

The activity of AMBRA1 in autophagy is modulated by upstream signaling pathways, including mTORC1, AMPK, and MAPK pathways, which integrate nutrient availability and cellular stresses.

Customer Reviews (3)

Write a review
Reviews
06/01/2019

    Easy integration into multi-omics workflows for comprehensive analysis.

    12/23/2018

      Wide dynamic range for accurate quantification of protein changes.

      11/18/2017

        Low false-positive rate in target protein identification.

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