AMBRA1
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Official Full Name
autophagy/beclin-1 regulator 1
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Synonyms
AMBRA1; autophagy/beclin-1 regulator 1; activating molecule in BECN1-regulated autophagy protein 1; DCAF3; DDB1 and CUL4 associated factor 3; FLJ20294; KIAA1736; WD repeat domain 94; WDR94; activating molecule in beclin-1-regulated autophagy; MGC33725;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AMBRA1 Related Articles
AMBRA1 involved in several pathways and played different roles in them. We selected most pathways AMBRA1 participated on our site, such as Cellular responses to stress, Macroautophagy, Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMBRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cellular responses to stress | NUPL2;RB1CC1;BMI1A;HIF1AL;GABARAP;UVRAG;SCMH1;H3F3D;RRAGB |
Macroautophagy | RB1CC1;MAP1LC3B;DYNLL2B;ATG9B;AMBRA1B;WDR45;WDR45L;ATG7;WIPI1 |
Senescence and Autophagy | UVRAG;MAP1LC3C;LC3;GABARAP;IFI16;RB1CC1;ING1;IL24;SLC39A3 |
AMBRA1 has several biochemical functions, for example, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMBRA1 itself. We selected most functions AMBRA1 had, and list some proteins which have the same functions with AMBRA1. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | VMP1;FTSJ3;ISOC1;DPM3;CREM;ASNS;KRT15;DDX11;SREK1 |
ubiquitin protein ligase binding | PML;HM13;CUL3A;ANKRD32;FBXW7;UBE2V2;UBE2KA;HSPA1B;EGR2 |
AMBRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMBRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AMBRA1.
BECN1; BCL2; vif
- Q&As
- Reviews
Q&As (10)
Ask a questionAMBRA1 undergoes post-translational modifications, including phosphorylation and ubiquitination, which regulate its interaction with other autophagy-related proteins and modulate its function in autophagy.
AMBRA1 participates in selective autophagy processes, such as mitophagy (selective clearance of damaged mitochondria) and aggrephagy (clearance of protein aggregates), contributing to cellular quality control mechanisms.
AMBRA1 plays a critical role in autophagy regulation by promoting autophagosome formation, facilitating cargo recognition and degradation, and coordinating the activity of other autophagy-related proteins.
AMBRA1 facilitates the clearance of protein aggregates and damaged organelles through autophagy, preventing their accumulation and mitigating cellular damage.
AMBRA1 expression is induced during autophagy by various signaling pathways, including nutrient deprivation, cellular stress, and growth factor signaling.
In addition to its role in autophagy, AMBRA1 interacts with other cellular processes, such as apoptosis and cell proliferation, forming intricate crosstalk that influences cellular fate and homeostasis.
AMBRA1 interacts with Beclin 1, ULK1, and ATG proteins through protein-protein interactions, forming complexes that regulate autophagy initiation and autophagosome formation.
Depletion of AMBRA1 leads to impaired autophagy activity, resulting in the accumulation of damaged proteins and organelles and compromised cellular homeostasis.
AMBRA1 promotes autophagosome formation by regulating the nucleation and elongation steps, ensuring proper assembly of the autophagy machinery and cargo sequestration.
The activity of AMBRA1 in autophagy is modulated by upstream signaling pathways, including mTORC1, AMPK, and MAPK pathways, which integrate nutrient availability and cellular stresses.
Customer Reviews (3)
Write a reviewEasy integration into multi-omics workflows for comprehensive analysis.
Wide dynamic range for accurate quantification of protein changes.
Low false-positive rate in target protein identification.
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