AMELX
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Official Full Name
Amelogenin, X-Linked
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Overview
This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in;biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta.;Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
AMELX; AMG; AI1E; AIH1; ALGN; AMGL; AMGX; amelogenin, X isoform; amelogenesis imperfecta 1; amelogenin (amelogenesis imperfecta 1, X-linked); amelogenin (X chromosome, amelogenesis imperfecta 1);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Yeast
- (AFPn)
- His
- TEV
- GST
- His (Fc)
- Avi
- Myc
- SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
AMELX involved in several pathways and played different roles in them. We selected most pathways AMELX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AMELX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
AMELX has several biochemical functions, for example, growth factor activity, hydroxyapatite binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMELX itself. We selected most functions AMELX had, and list some proteins which have the same functions with AMELX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | Fgf15;PGF;IL9;BMP7B;TIMP1;FGF12A;FGF6B;FGF8;NTF3 |
| hydroxyapatite binding | BGLAP;PTPLA;HTN1;STATH;BGLAP2;AMELX |
| identical protein binding | CD28;SSNA1;ATG101;TRIP13;MAP3K13;DIAP1;NONO;SOX10;PRMT8 |
| protein binding | TMEM183A;CA8;RAB11FIP5;TOMM20;SREK1IP1;RIPK2;GLTP;NCK1;RFC2 |
| structural constituent of tooth enamel | AMELX;AMELY;STATH;TUFT1;AMBN |
AMELX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMELX here. Most of them are supplied by our site. Hope this information will be useful for your research of AMELX.
- Q&As
- Reviews
Q&As (10)
Ask a questionAMELX undergoes various post-translational modifications, including phosphorylation and glycosylation, which contribute to its proper folding, secretion, and enamel matrix assembly.
AMELX gene regulation during tooth development is orchestrated by a complex interplay of transcription factors, epigenetic modifications, and signaling pathways, ensuring precise spatiotemporal expression for enamel formation.
AMELX contributes to the mechanical properties of enamel, such as its hardness, resilience, and wear resistance, through its involvement in enamel crystal organization and interlocking.
Manipulating AMELX expression or activity holds potential for enamel regeneration strategies, such as promoting ameloblast differentiation from stem cells or developing biomimetic materials that mimic the composition and structure of natural enamel for tooth repair and restoration.
Mutations or deletions in the AMELX gene result in amelogenesis imperfecta, leading to enamel defects, such as hypoplasia or hypomineralization, and compromised tooth integrity.
AMELX interacts with other enamel matrix proteins, such as amelogenin and enamelin, as well as extracellular matrix components, facilitating enamel matrix assembly, organization, and mineralization.
Signaling pathways, including Wnt, BMP, and FGF signaling, regulate AMELX expression and function, coordinating ameloblast differentiation, enamel secretion, and mineralization processes.
AMELX is highly expressed in ameloblasts, the cells responsible for enamel formation, and its role involves the synthesis and secretion of enamel matrix proteins essential for enamel structure and hardness.
AMELX plays a critical role in enamel mineralization by participating in the nucleation and growth of hydroxyapatite crystals, influencing their size, orientation, and arrangement within the enamel matrix.
AMELX expression may change during tooth aging or in dental diseases, reflecting altered enamel turnover, enamel remineralization processes, or adaptive responses to pathological conditions.
Customer Reviews (3)
Write a reviewPrecise quantification of protein expression changes in disease states.
Reduced assay background noise for improved signal-to-noise ratio.
Wide range of available detection methods for versatility.
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