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AMPK

  • Official Full Name

    AMPK

Species Cat.# Product name Source (Host) Tag Protein Length Price
Kit-0088 AMPK Phosphorylation Assay Kit N/A
  • AMPK Related Research Area

AMPK involved in several pathways and played different roles in them. We selected most pathways AMPK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AMPK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AMPK has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by AMPK itself. We selected most functions AMPK had, and list some proteins which have the same functions with AMPK. You can find most of the proteins on our site.

Function Related Protein

AMPK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMPK here. Most of them are supplied by our site. Hope this information will be useful for your research of AMPK.

  • Q&As
  • Reviews

Q&As (15)

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Can AMPK activation protect against neurodegenerative diseases? 02/27/2023

AMPK activation has shown promise in protecting against neurodegenerative diseases. Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by the impaired clearance of misfolded proteins and mitochondrial dysfunction. AMPK activation has been found to enhance autophagy, a cellular process involved in removing damaged proteins and organelles, thereby reducing the accumulation of toxic aggregates associated with neurodegeneration.

Does AMPK activation have any impact on weight loss? 08/26/2022

AMPK activation has been suggested to play a role in weight loss. AMPK activation can stimulate fat burning and increase energy expenditure, which can potentially aid in weight loss. It promotes the breakdown of fatty acids in adipose tissue and increases the uptake and utilization of glucose in muscles, promoting the shift towards utilizing stored energy sources. Additionally, AMPK activation may promote satiety by modulating appetite-regulating hormones. However, the impact of AMPK activation on weight loss may vary among individuals and can be influenced by various factors, such as diet, exercise, and overall metabolic health.

How is the AMPK protein regulated? 01/01/2022

AMPK protein is regulated by a combination of allosteric activation and phosphorylation. Allosteric activation occurs when AMP or ADP bind to the regulatory region of AMPK, causing a conformational change that increases its activity. Phosphorylation of specific sites on AMPK by kinases, such as LKB1 and CAMKKβ, also leads to its activation. Additionally, other factors, such as changes in calcium levels and intracellular calcium signaling, can influence AMPK activity. The precise regulation of AMPK is still an active area of research.

How is AMPK protein activated? 07/13/2021

AMPK protein is activated by the binding of AMP (adenosine monophosphate) or ADP (adenosine diphosphate), which reflect low cellular energy levels. The presence of AMP or ADP allosterically activates AMPK by causing a conformational change that promotes phosphorylation of the protein on specific sites. Additionally, the kinase LKB1 and the tumor suppressor CAMKKβ can phosphorylate AMPK, leading to its activation.

What are the downstream signaling pathways of AMPK protein? 06/01/2021

Upon activation, AMPK protein phosphorylates a variety of downstream targets to mediate its effects on cellular metabolism. It can phosphorylate and inhibit acetyl-CoA carboxylase (ACC), reducing fatty acid synthesis and promoting fatty acid oxidation. AMPK also phosphorylates and activates enzymes involved in glucose uptake and glycolysis, as well as transcription factors such as PGC-1α involved in mitochondrial biogenesis.

Can AMPK protein be targeted for cancer treatment? 01/16/2020

Yes, AMPK protein can be targeted for cancer treatment. AMPK activation has been shown to inhibit cell growth and induce cell cycle arrest, making it a potential therapeutic target for cancer. However, the role of AMPK in cancer is complex, as its effects can vary depending on the tumor type and stage. Some studies suggest that AMPK activation may have anticancer effects by inhibiting cancer cell proliferation and promoting apoptosis. However, in certain cases, AMPK activation may also enhance tumor cell survival under metabolic stress. Further research is needed to fully understand the implications of AMPK modulation in cancer treatment.

Does AMPK activation play a role in inflammation? 09/13/2019

Yes, AMPK activation can play a role in inflammation. AMPK has been found to regulate inflammatory responses in various cell types. Activation of AMPK can suppress the production of pro-inflammatory molecules, such as cytokines and chemokines, and inhibit the activity of key inflammatory signaling pathways.

Are there any drugs that target AMPK protein? 07/25/2019

Yes, there are drugs that target AMPK protein directly or indirectly. For example, metformin, a commonly used antidiabetic drug, indirectly activates AMPK by inhibiting mitochondrial complex I and increasing AMP levels. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) is another compound that can activate AMPK by mimicking the effects of AMP. Additionally, several novel small-molecule compounds are being developed as direct AMPK activators, with the aim of modulating cellular energy metabolism for therapeutic purposes.

Are there any drugs that target AMPK? 10/03/2018

Yes, there are drugs available that target AMPK. For example, metformin, a widely used medication for type 2 diabetes, is known to activate AMPK. Metformin enhances AMPK activity in the liver, leading to decreased glucose production and improved insulin sensitivity. Another drug called AICAR (aminoimidazole carboxamide ribonucleotide) can directly activate AMPK and has been used in research studies to study AMPK signaling pathways. Additionally, there are ongoing efforts to develop specific AMPK activators or inhibitors as potential therapeutic agents for various diseases, including cancer, metabolic disorders, and neurodegenerative conditions.

Are there any natural compounds that can activate AMPK? 10/06/2017

Yes, there are several natural compounds that have been found to activate AMPK. One well-known compound is resveratrol, found in red grapes and red wine. Resveratrol has been shown to activate AMPK and mimic some of the beneficial effects of calorie restriction, such as increased insulin sensitivity and improved mitochondrial function.

Can AMPK activation impact cardiovascular health? 08/06/2017

Yes, AMPK activation can impact cardiovascular health. AMPK plays a crucial role in maintaining energy homeostasis in cardiovascular tissues, such as the heart and blood vessels. Activation of AMPK in the heart has been shown to protect against cardiac hypertrophy, reduce oxidative stress, and improve cardiac function. In blood vessels, AMPK activation can enhance nitric oxide production and promote vasodilation, which helps maintain vascular health and regulate blood pressure.

Does AMPK play a role in aging? 08/04/2017

Yes, AMPK is believed to play a role in aging. Aging is associated with a decline in cellular energy metabolism and an increase in metabolic dysfunction. AMPK activation has been shown to promote various cellular processes that are linked to aging, such as mitochondrial biogenesis, autophagy, and maintenance of cellular homeostasis.

Can AMPK activation improve exercise performance? 06/07/2017

There is evidence to suggest that AMPK activation can improve exercise performance. AMPK plays a role in regulating energy metabolism during exercise, helping to enhance glucose uptake and utilization, promote fatty acid oxidation, and maintain cellular energy balance. Activation of AMPK during exercise is thought to increase endurance and metabolic efficiency. However, it is important to note that the effects of AMPK activation on exercise performance can be influenced by various factors, including the intensity and duration of exercise, as well as individual differences in genetics and training status.

Are there any diseases where the activation of AMPK protein is beneficial? 01/12/2017

Activation of AMPK has shown potential benefits in various diseases. For example, in metabolic disorders like obesity and type 2 diabetes, AMPK activation improves glucose uptake, insulin sensitivity, and lipid metabolism. In cardiovascular diseases, AMPK activation can improve cardiac function and protect against ischemic injury.

What are the implications of AMPK dysfunction? 03/15/2016

Dysregulation of AMPK activity has been associated with various diseases, including metabolic disorders like obesity, type 2 diabetes, and cardiovascular diseases. Reduced AMPK activity can lead to impaired energy metabolism, insulin resistance, and accumulation of metabolic intermediates. On the other hand, excessive activation of AMPK can disrupt normal cellular processes and contribute to certain pathologies, such as neurodegenerative diseases.

Customer Reviews (4)

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Reviews
04/25/2023

    I am profoundly impressed by the technical support rendered by the manufacturer.

    09/30/2021

      the AMPK protein stands out for its exceptional quality, coupled with the outstanding technical support delivered by the manufacturer.

      10/21/2020

        Its unwavering stability and functionality have significantly contributed to the success and validity of my experimental outcomes.

        12/18/2018

          Trusting in its consistent results, I am able to embark on my research with assurance and optimism.

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