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AMTN

  • Official Full Name

    amelotin

  • Synonyms

    AMTN;amelotin;33188;ENSG00000187689;UNQ689;4q13.3;MGC148132, MGC148133;amelotin;amelotin;RSTI689;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • mFc
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AMTN-221H Recombinant Human AMTN protein(Met1-Gln209), mFc-tagged HEK293 C-mFc Met1-Gln209
Human AMTN-390H Recombinant Human amelotin, His-tagged E.coli His
Human AMTN-532H Recombinant Human AMTN protein, GST-tagged Wheat Germ GST
Human AMTN-9627H Recombinant Human AMTN, GST-tagged E.coli GST 1-209a.a.
Human AMTN-1023H Recombinant Human AMTN Mammalian Cell His
Human AMTN-001HCL Recombinant Human AMTN cell lysate Human Cell N/A
Human AMTN-1317HF Recombinant Full Length Human AMTN Protein, GST-tagged In Vitro Cell Free System GST 209 amino acids
Human AMTN-2464H Recombinant Human AMTN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AMTN-2464H-B Recombinant Human AMTN Protein Pre-coupled Magnetic Beads HEK293
Mouse AMTN-1611M Recombinant Mouse AMTN Protein Mammalian Cell His
Mouse AMTN-513M Recombinant Mouse AMTN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AMTN-513M-B Recombinant Mouse AMTN Protein Pre-coupled Magnetic Beads HEK293
Rat AMTN-661R Recombinant Rat AMTN Protein Mammalian Cell His
Rat AMTN-317R-B Recombinant Rat AMTN Protein Pre-coupled Magnetic Beads HEK293
Rat AMTN-317R Recombinant Rat AMTN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AMTN Related Articles

AMTN involved in several pathways and played different roles in them. We selected most pathways AMTN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AMTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AMTN has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by AMTN itself. We selected most functions AMTN had, and list some proteins which have the same functions with AMTN. You can find most of the proteins on our site.

Function Related Protein
molecular_functionMYOZ1B;MXRA8B;PPFIBP2;TMEM179;GM11744;GM13298;PM20D1;TUSC2A;SIRP-BETA

AMTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMTN here. Most of them are supplied by our site. Hope this information will be useful for your research of AMTN.

Nakayama, Y; Takai, H; et al. Proinflammatory cytokines induce amelotin transcription in human gingival fibroblasts. JOURNAL OF ORAL SCIENCE 56:261-268(2014).
Moffatt, P; Wazen, RM; et al. Characterisation of secretory calcium-binding phosphoprotein-proline-glutamine-rich 1: a novel basal lamina component expressed at cell-tooth interfaces. CELL AND TISSUE RESEARCH 358:843-855(2014).
  • Q&As
  • Reviews

Q&As (11)

Ask a question
How is the AMTN protein synthesized and processed? 04/24/2023

The AMTN protein is synthesized in dental cells as a precursor molecule, known as preproamelotin. This precursor undergoes post-translational modifications within the endoplasmic reticulum and Golgi apparatus, including cleavage of the signal peptide, glycosylation, and phosphorylation, to form the mature AMTN protein. The mature AMTN protein is then secreted into the extracellular space where it functions in dental tissue development.

Are there any known interactions of the AMTN protein with other proteins? 01/21/2023

Several studies have identified potential interactions of the AMTN protein with other proteins involved in tooth development and mineralization. For example, AMTN has been reported to interact with the enamelin protein, which is another critical component of enamel formation.

Are there any genetic disorders associated with mutations in the AMTN gene? 05/07/2021

Yes, mutations in the AMTN gene have been linked to a rare genetic disorder called amelogenesis imperfecta. This condition affects the formation and mineralization of dental enamel, leading to abnormal tooth development, enamel defects, and dental abnormalities.

Are there any other tissues or organs where the AMTN protein is expressed? 02/16/2020

The AMTN protein is primarily expressed in dental tissues, including enamel, dentin, and cementum. However, there is emerging evidence to suggest some low-level expression of AMTN in other tissues. For example, studies have detected AMTN expression in salivary glands, oral mucosa, and certain types of cancer cells. Further research is needed to explore the extent of AMTN expression in non-dental tissues and its potential physiological significance.

What are some clinical implications of AMTN mutations? 07/17/2019

Mutations in the AMTN gene have been associated with various types of amelogenesis imperfecta, a group of inherited disorders characterized by defects in enamel formation. These mutations can lead to enamel abnormalities such as thin enamel, enamel loss, enamel hypoplasia (reduced enamel formation), and enamel that is prone to breakdown or staining.

What are the functions of the AMTN protein in dental tissue development? 07/03/2018

The AMTN protein plays a crucial role in dental tissue development, particularly in the formation and mineralization of enamel. Enamel is the outer layer of the tooth and is the hardest tissue in the human body. AMTN contributes to enamel development by regulating the growth and organization of enamel crystals, promoting their alignment and proper arrangement. AMTN also interacts with other enamel matrix proteins, facilitating their assembly and secretion, ultimately contributing to the formation of a strong and durable enamel layer.

How can AMTN mutations cause amelogenesis imperfecta? 06/20/2018

Mutations in the AMTN gene can lead to amelogenesis imperfecta, a condition characterized by abnormal enamel formation. These mutations often disrupt the structure or function of the AMTN protein, leading to impaired enamel maturation, decreased enamel thickness, or loss of enamel formation altogether. These defects can result in enamel that is poorly mineralized, softer than normal, or prone to chipping, resulting in the dental abnormalities observed in amelogenesis imperfecta patients.

Is the expression of AMTN regulated by any specific factors or signaling pathways? 04/19/2018

The expression of AMTN is regulated by multiple factors and signaling pathways involved in tooth development. Studies have shown that AMTN expression is influenced by transcription factors such as Runx2 and Osterix, which are key regulators of tooth mineralization. Additionally, various signaling pathways, including the Wnt and BMP pathways, appear to be involved in the regulation of AMTN expression.

What are the structural features of the AMTN protein? 01/07/2018

The AMTN protein is known to contain an N-terminal signal peptide that aids in its secretion from cells. It also has a conserved C-terminal domain known as the "ASAP1 domain" that is characteristic of AMTN proteins. This domain is thought to play a role in protein-protein interactions and the formation of protein complexes.

Can AMTN protein be used for diagnostic or therapeutic purposes? 09/18/2017

The AMTN protein has the potential to be used for diagnostic purposes, particularly in identifying genetic mutations associated with amelogenesis imperfecta. Genetic testing for AMTN mutations can help diagnose the condition and provide valuable information for personalized treatment planning.

Are there any known functional variations or polymorphisms in the AMTN gene? 09/02/2017

Several studies have identified functional variations and polymorphisms in the AMTN gene that may have implications for dental health and disease. For example, certain variations in the AMTN gene have been associated with an increased risk of dental caries (tooth decay) and susceptibility to periodontal disease. Additionally, some polymorphisms in the AMTN gene have been linked to variations in enamel thickness and tooth shape.

Customer Reviews (5)

Write a review
Reviews
04/23/2022

    AMTN protein is known for its stability and robustness, making it suitable for a wide range of experimental conditions.

    01/01/2021

      Its resistance to degradation and denaturation allows for longer storage times and repeated use without compromising its performance or functionality.

      11/07/2019

        This specificity enables precise quantification and characterization of AMTN and its interactions with other molecules or proteins of interest.

        05/06/2017

          When used in Western blotting experiments, the AMTN protein produces distinct protein bands, allowing for easy visualization and interpretation.

          10/05/2016

            The AMTN protein exhibits a high degree of specificity in various assays, ensuring accurate and reliable results.

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