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ANAPC1

  • Official Full Name

    anaphase promoting complex subunit 1

  • Overview

    ANAPC1 is 1 of at least 10 subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.
  • Synonyms

    ANAPC1; anaphase promoting complex subunit 1; anaphase-promoting complex subunit 1; APC1; MCPR; TSG24; cyclosome subunit 1; mitotic checkpoint regulator; testis-specific gene 24 protein; anaphase-promoting complex 1 (meiotic checkpoint regulator);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANAPC1-9633H Recombinant Human ANAPC1, His-tagged E.coli His C-term-349a.a.
Human ANAPC1-540H Recombinant Human ANAPC1 protein, GST-tagged Wheat Germ GST
Mouse Anapc1-3448M Recombinant Mouse Anapc1, His-tagged E.Coli or Yeast His 1944
Mouse ANAPC1-1619M Recombinant Mouse ANAPC1 Protein Mammalian Cell His
Mouse ANAPC1-519M Recombinant Mouse ANAPC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ANAPC1-519M-B Recombinant Mouse ANAPC1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ANAPC1 Related Articles

ANAPC1 involved in several pathways and played different roles in them. We selected most pathways ANAPC1 participated on our site, such as Cell cycle, Oocyte meiosis, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANAPC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleYWHAE1;SFN;TUBGCP2;FZR1A;RAD1;PLK1;RB1;AKAP9;PKMYT1
Oocyte meiosisPGR;CCNE2;PPP3R2;CPEB4;PPP1CC;PTTG2;Ar;SPDYB;CALM1B
Ubiquitin mediated proteolysisPML;KLHL13;CUL2;BIRC8;ANAPC5;NHLRC1;UBE2E1;ANAPC13;UBE2N
Progesterone-mediated oocyte maturationRPS6KAL;PIK3CD;INS2;PRKACG;MAPK14B;CCNA2;MAPK3;ANAPC2;HSP90AA1
HTLV-I infectionVDAC2;STAT5A;RRAS2;TNF;HLA-G;HLA-DMB;MAP2K4;ATF3;PPP3CC

ANAPC1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ANAPC1 itself. We selected most functions ANAPC1 had, and list some proteins which have the same functions with ANAPC1. You can find most of the proteins on our site.

Function Related Protein

ANAPC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANAPC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANAPC1.

CDC16; Cdc23; Cdc16; Cdc26; Anapc16; Cdc20; Bub1b

Ho, AW; Garg, AV; et al. The Anaphase-Promoting Complex Protein 5 (AnapC5) Associates with A20 and Inhibits IL-17-Mediated Signal Transduction. PLOS ONE 8:-(2013).
Holzmann, J; Fuchs, J; et al. Lesson from the Stoichiometry Determination of the Cohesin Complex: A Short Protease Mediated Elution Increases the Recovery from Cross-Linked Antibody-Conjugated Beads. JOURNAL OF PROTEOME RESEARCH 10:780-789(2011).
  • Q&As
  • Reviews

Q&As (15)

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Are there any genetic variants of ANAPC1 associated with diseases? 01/26/2022

While mutations in the ANAPC1 gene have been linked to familial adenomatous polyposis (FAP), a genetic condition that predisposes individuals to the development of colorectal polyps, there are currently no other known disease-associated genetic variants of ANAPC1. More extensive research is needed to determine if ANAPC1 mutations or genetic variations are associated with other diseases.

Are there any specific drugs or compounds that target ANAPC1? 11/06/2021

As of now, there are no specific drugs or compounds that directly target ANAPC1. However, research is ongoing to identify small molecules or inhibitors that can modulate the activity of the APC/C complex, which could indirectly affect ANAPC1 function.

Are there any known interacting partners of ANAPC1? 07/14/2021

ANAPC1 interacts with various other proteins to form the APC/C complex. Some known interacting partners include ANAPC2, ANAPC3, ANAPC4, and ANAPC5, which are subunits of the complex. Additionally, ANAPC1 interacts with other regulatory proteins and co-factors involved in the control of APC/C activity.

Is ANAPC1 protein expressed in all cell types? 11/12/2020

ANAPC1 is widely expressed in various cell types and tissues throughout the body. Its presence is essential for normal cell cycle progression in all dividing cells.

How does ANAPC1 regulate the cell cycle? 06/25/2020

ANAPC1, along with other subunits of the APC/C complex, targets specific proteins for degradation by attaching ubiquitin molecules to them. This ubiquitination process marks these proteins for destruction by the proteasome, leading to the orderly progression of the cell cycle.

Are there any known regulatory mechanisms that control ANAPC1 expression or activity? 06/19/2019

ANAPC1 expression and activity can be regulated by factors such as phosphorylation, interaction with other proteins, or cell cycle checkpoints. The precise regulatory mechanisms of ANAPC1 are still being elucidated.

Are there any other diseases or conditions associated with ANAPC1? 02/25/2019

Apart from cancer, ANAPC1 has been implicated in other diseases as well. For example, mutations in ANAPC1 have been linked to familial adenomatous polyposis (FAP), an inherited disorder characterized by the development of numerous polyps in the colon. These mutations likely disrupt the normal function of the APC/C complex, leading to abnormal cell proliferation and polyp formation.

Is ANAPC1 protein conserved across different species? 02/14/2019

Yes, ANAPC1 is a highly conserved protein across various species, ranging from yeast to humans. The conservation of ANAPC1 highlights its importance in fundamental cell cycle processes that are essential for the development and survival of organisms.

How is ANAPC1 protein regulated during the cell cycle? 01/28/2019

ANAPC1 expression levels and activity are tightly regulated during the cell cycle. Its levels are generally low during the G1 phase but increase as cells progress through the S, G2, and M phases. ANAPC1 activity is regulated by post-translational modifications, such as phosphorylation and acetylation, which can affect its interaction with other subunits of the APC/C complex and its binding to specific substrates.

Can ANAPC1 be targeted for therapeutic interventions? 01/06/2019

Given its role in the cell cycle regulation and its involvement in cancer, ANAPC1 has emerged as a potential target for therapeutic interventions. However, more research is needed to fully understand the implications and feasibility of targeting ANAPC1 for various diseases.

Are there any known mutations in ANAPC1 associated with diseases? 05/26/2018

Mutations in ANAPC1 have been found in certain types of cancer, including colorectal and gastric cancer. These mutations can disrupt the normal function of the APC/C complex, leading to aberrant cell cycle regulation and promoting tumor growth.

Does ANAPC1 play a role in DNA repair? 03/29/2018

Emerging evidence suggests that ANAPC1 may have a role in DNA repair mechanisms. It has been found to interact with proteins involved in DNA repair pathways, such as BRCA1 and RAD51, indicating a potential role in maintaining genomic stability. However, further studies are needed to fully understand the significance of ANAPC1 in DNA repair processes.

Does ANAPC1 have any other cellular functions besides cell cycle regulation? 03/17/2017

ANAPC1 primarily functions as a core component of the APC/C complex, which is responsible for cell cycle progression. However, recent studies have suggested that ANAPC1 may also have additional roles in transcriptional regulation and chromatin organization, indicating its involvement in other cellular processes beyond cell cycle regulation.

Does ANAPC1 have any non-cell cycle related functions? 12/15/2016

While the main function of ANAPC1 is cell cycle regulation, emerging research suggests that it may have additional roles in processes like DNA repair and maintenance of genomic stability. However, further investigation is needed to fully understand these potential non-cell cycle related functions of ANAPC1.

Can ANAPC1 be targeted for therapeutic interventions? 05/02/2016

As ANAPC1 plays a crucial role in cell cycle regulation, targeting it therapeutically could potentially be beneficial for certain diseases, especially cancer. However, developing specific inhibitors or modulators that specifically target ANAPC1 or the APC/C complex is not straightforward and requires further research.

Customer Reviews (5)

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Reviews
10/21/2022

    The protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.

    10/05/2020

      As a researcher utilizing ANAPC1 protein in my trials, I can highlight its advantages and the valuable support provided by the manufacturer in facilitating my research.

      07/07/2020

        The protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.

        12/06/2016

          By using ANAPC1 protein, I can explore the mechanisms underlying cell division, cell cycle control, and the molecular pathways associated with these processes.

          11/12/2016

            One major advantage of ANAPC1 protein is its ability to contribute to the understanding of diseases related to aberrant cell cycle regulation, including cancer.

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