ANAPC2
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Official Full Name
anaphase promoting complex subunit 2
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Overview
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. -
Synonyms
ANAPC2; anaphase promoting complex subunit 2; APC2; RP11-350O14.5; Anaphase-promoting complex subunit 2; Cyclosome subunit 2; KIAA1406; OTHUMP00000022692;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ANAPC2 Related Articles
ANAPC2 involved in several pathways and played different roles in them. We selected most pathways ANAPC2 participated on our site, such as Cell cycle, Oocyte meiosis, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANAPC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell cycle | BUB1;MDM2;RB1;GADD45AB;CCND3;TERF2IP;INCENP;GADD45A;PCM1 |
Oocyte meiosis | YWHAH;RPS6KA3A;IGF1RA;FBXW11B;CDC16;FBXO43;YWHABA;YWHAQB;INS2 |
Ubiquitin mediated proteolysis | UBOX5;ANAPC2;CUL3A;NEDD4;RNF7;KLHL9;UBE2B;UBE2Q1;UBE2G1A |
Progesterone-mediated oocyte maturation | MAPK8B;ANAPC13;PRKACA;HSP90AA1.1;MAPK12;CCNB1;INS;RAF1B;RPS6KA3A |
HTLV-I infection | PRKACG;NFYB;PPP3CC;AKT2;Il2;ANAPC7;RRAS2;FZD3;APC2 |
ANAPC2 has several biochemical functions, for example, contributes_to ubiquitin protein ligase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANAPC2 itself. We selected most functions ANAPC2 had, and list some proteins which have the same functions with ANAPC2. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to ubiquitin protein ligase activity | CUL3;FBXL3A;ANAPC2;FBXL14;CUL1B;FBXL5;CUL5A;FBXL3B;FBXL7 |
ubiquitin protein ligase binding | TCP1;C10orf46;ANAPC2;PINK1;HSPA1L;TRAF1;UBE2V1;IKBKG;TRP53 |
ANAPC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANAPC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANAPC2.
Cdc23; Cdc16; Cdc26; Cdc20; CDC27; CDC16; CDC23; MAGEB2
- Q&As
- Reviews
Q&As (20)
Ask a questionAs ANAPC2 plays a crucial role in cell cycle regulation, it has the potential to be targeted for therapeutic interventions. However, at present, there are no specific therapies that directly target ANAPC2. Research is ongoing to explore the potential of ANAPC2 as a therapeutic target for cancer and other diseases.
While the primary function of ANAPC2 is in cell cycle regulation, it indirectly influences DNA repair processes by ensuring proper cell cycle control and accurate chromosome segregation during mitosis. By preventing the accumulation of damaged DNA, ANAPC2 indirectly contributes to maintaining genome stability and integrity.
ANAPC2 is critical for cell viability. Studies using cell lines with ANAPC2 knockdown or knockout have shown severe defects in cell cycle progression, leading to cell cycle arrest and cell death. This highlights the essential role of ANAPC2 in cellular processes.
Studies have shown that dysregulation or mutations in ANAPC2 can have significant impacts on cell cycle control and genomic stability, which can contribute to the development of various diseases. For example, ANAPC2 mutations have been associated with colorectal cancer and hepatocellular carcinoma.
Loss-of-function mutations in ANAPC2 can have severe consequences on cell cycle regulation and genomic stability. Studies in animal models have shown that ANAPC2 deficiency leads to embryonic lethality due to disrupted cell proliferation and improper organ development. In human cells, ANAPC2 mutations can contribute to various diseases, including cancer, by disrupting the normal control mechanisms of the cell cycle.
ANAPC2 can undergo post-translational modifications, such as phosphorylation and acetylation, which can potentially regulate its stability and activity. These modifications can be critical for proper cell cycle control.
The dysregulation of the cell cycle machinery, including ANAPC2, is a hallmark of cancer. Targeting components of the cell cycle, including ANAPC2, is an area of active research for developing novel cancer therapies. Inhibitors of the APC/C complex or ANAPC2-specific molecules may hold potential for selectively targeting cancer cells and disrupting their cell cycle progression.
ANAPC2 is a subunit of the APC/C complex, which is one of the key regulators of the cell cycle progression. APC/C interacts with various proteins and pathways involved in cell cycle control, including cyclins, cyclin-dependent kinases (CDKs), E3 ligases, and checkpoint regulators. ANAPC2 interacts with other subunits of the APC/C complex to facilitate protein degradation and ensure proper cell cycle transitions.
ANAPC2 forms tight complexes with other subunits of the APC/C complex, including ANAPC3, ANAPC7, and ANAPC10. These interactions are necessary for the stability and activity of the complex.
ANAPC2 expression levels or genetic variations in ANAPC2 have been investigated as potential biomarkers for certain diseases, particularly cancer. Changes in ANAPC2 expression or mutations may be indicative of altered cell cycle regulation and genomic instability. However, more research is needed to establish ANAPC2 as a reliable biomarker.
ANAPC2 indirectly contributes to maintaining genome stability by ensuring proper cell cycle control and regulation of chromosome segregation during mitosis. By targeting proteins involved in DNA replication, repair, and cell division for degradation, ANAPC2 helps prevent errors in genome replication and segregation.
While ANAPC2's primary role is in cell cycle regulation, dysregulation of the APC/C complex, including ANAPC2, can have broader implications in other cellular pathways. For example, defects in APC/C function can lead to chromosomal instability, aberrant DNA repair, and altered cellular signaling. Understanding these interactions can provide insights into the role of ANAPC2 in various cellular processes.
While ANAPC2 is primarily studied in the context of cancer, its dysregulation and role in cell cycle control may have implications in other diseases. Further research is needed to determine if ANAPC2 can be targeted for therapeutic interventions in diseases like neurodegenerative disorders, autoimmune diseases, or developmental disorders.
There is limited research suggesting potential links between ANAPC2 and neurodegenerative disorders. ANAPC2 has been identified in genetic studies in relation to amyotrophic lateral sclerosis (ALS) and Parkinson's disease, but these associations require further investigation to clarify the exact role of ANAPC2 in neurodegeneration.
ANAPC2 mutations have the potential to impact drug response in cancer treatment. Dysregulation of the cell cycle machinery, including ANAPC2, can lead to uncontrolled cell growth and resistance to chemotherapy agents that target proliferating cells. Further research is needed to fully understand how ANAPC2 mutations may contribute to drug resistance and potential strategies to overcome it.
Genetic variations in ANAPC2 have been identified through genome sequencing studies. These variations can include single nucleotide polymorphisms (SNPs), insertions, deletions, or structural variations. Some of these genetic variations may have functional consequences and could be associated with disease susceptibility or progression.
ANAPC2 is essential for proper embryonic development. Studies in animal models have shown that loss of ANAPC2 function leads to embryonic lethality, indicating its critical role in early development. ANAPC2 is required for cell proliferation, differentiation, and normal organ formation during embryogenesis.
ANAPC2's direct interactions with the immune system are not well established. However, as ANAPC2 is involved in cell cycle regulation and genomic stability, dysregulation of ANAPC2 or APC/C complex function could potentially impact immune cell proliferation, differentiation, and response to infection or immunotherapy. Further studies are needed to understand the involvement of ANAPC2 in immune system regulation.
ANAPC2 is a large protein subunit composed of around 900 amino acids. It contains several functional domains, including an N-terminal TPR (tetratricopeptide repeat) domain involved in protein-protein interactions and a C-terminal domain responsible for the catalytic activity of the APC/C complex. The three-dimensional structure of ANAPC2 has been determined through research.
ANAPC2 primarily interacts with other subunits of the APC/C complex to carry out its functions in cell cycle regulation. However, dysregulation of the APC/C complex, including ANAPC2, can have broader implications in cellular pathways involved in DNA repair, chromosomal stability, and cell proliferation.
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Write a reviewthe manufacturer's commitment to scientific collaboration and knowledge sharing greatly enhances my research experience.
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