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ANTXR1

  • Official Full Name

    anthrax toxin receptor 1

  • Overview

    This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
  • Synonyms

    ANTXR1; anthrax toxin receptor 1; anthrax toxin receptor; ATR; FLJ10601; FLJ21776; TEM8; tumor endothelial marker 8 precursor; 2310008J16Rik; 2810405N18Rik; tumor endothelial marker 8; FLJ11298;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANTXR1-7358H Recombinant Human ANTXR1, Fc tagged Human Cell Fc
Human ANTXR1-625H Recombinant Human ANTXR1 protein, GST-tagged Wheat Germ GST
Human ANTXR1-38H Recombinant Human ANTXR1, His-tagged HEK293 His
Human ANTXR1-1463HCL Recombinant Human ANTXR1 cell lysate Human Cell N/A
Human ANTXR1-2158H Recombinant Human ANTXR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ANTXR1-2478H Recombinant Human ANTXR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ANTXR1-2117H Recombinant Human ANTXR1 Protein, His-tagged Yeast His
Human ANTXR1-5916H Recombinant Human ANTXR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ANTXR1-160H Recombinant Human ANTXR1 Protein, His-tagged E.coli N-His Glu33-Glu321
Human ANTXR1-1475HF Recombinant Full Length Human ANTXR1 Protein, GST-tagged In Vitro Cell Free System GST 368 amino acids
Human ANTXR1-0099H Recombinant Human ANTXR1 Protein (Glu33-Lys321), C-His-tagged Mammalian cells C-His Glu33-Lys321
Mouse ANTXR1-1707M Recombinant Mouse ANTXR1 Protein Mammalian Cell His
Mouse Antxr1-1646M Recombinant Mouse Antxr1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ANTXR1-2069M Recombinant Mouse ANTXR1 Protein (31-319 aa), His-tagged E.coli His 31-319 aa
Mouse ANTXR1-575M Recombinant Mouse ANTXR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ANTXR1-575M-B Recombinant Mouse ANTXR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Antxr1-4985M Recombinant Mouse Antxr1 protein, His-tagged HEK293 His 31-319aa
Mouse ANTXR1-2342M Recombinant Mouse ANTXR1 Protein (31-319 aa), His-tagged Yeast His 31-319 aa
Rat ANTXR1-687R Recombinant Rat ANTXR1 Protein Mammalian Cell His
Rat ANTXR1-343R-B Recombinant Rat ANTXR1 Protein Pre-coupled Magnetic Beads HEK293
Rat ANTXR1-343R Recombinant Rat ANTXR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ANTXR1 Related Research Area

ANTXR1 involved in several pathways and played different roles in them. We selected most pathways ANTXR1 participated on our site, such as Cellular roles of Anthrax toxin, Disease, Infectious disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANTXR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular roles of Anthrax toxinANTXR2;DEFA1;ANTXR1
DiseaseFGFR1OP;CDK9;NMT1;KPNA4;NMT2;TCEA1;gag;PRELP;CCDC59
Infectious diseaseCHMP4B;LTF;PACS1;IPO5;VPS37A;KPNA3;SYT2;APOBEC3G;CPSF4
Uptake and actions of bacterial toxinsANTXR2;SYT2;ANTXR1;PDCD6IP
Uptake and function of anthrax toxinsANTXR1;ANTXR2

ANTXR1 has several biochemical functions, for example, actin filament binding, collagen binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANTXR1 itself. We selected most functions ANTXR1 had, and list some proteins which have the same functions with ANTXR1. You can find most of the proteins on our site.

Function Related Protein
actin filament bindingSYNE1;EGFR;ADSSL1;TRIOBPB;TLN2A;PPP1R9A;TAGLN3A;EZR;NEBL
collagen bindingACHE;COMP;MRC2;SERPINH1B;PODN;ASPN;ITGA3;ITGA10;SPARC
metal ion bindingNT5DC1;CTCFL;ZBTB12.2;GALNTL1;ZFP458;CTDSPL;TRAFD1;CYP4A14;DRL
protein bindingSBDS;AKAP12;CCL3;TMEM115;TNIK;RWDD1;INADL;PPP1R2P9;SUV420H2
transmembrane signaling receptor activityOR6K3;LILRB5;THBD;IL27RA;NPR2;TLR2;CD27;BAI2;CR2

ANTXR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANTXR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANTXR1.

PCOLCE; LRP6; KLF8; SYN1; FLNA; GJB2; MYH9; Ppp1cb; Tecpr2; Bsdc1; Sidt2; MYO19

  • Q&As
  • Reviews

Q&As (35)

Ask a question
Is ANTXR1 expressed in all types of cells? 04/18/2023

ANTXR1 is expressed in a wide range of cell types, including endothelial cells, fibroblasts, macrophages, and various cancer cell lines. However, the level of expression may vary depending on the cell type and its physiological state.

Are there any known alternative splicing isoforms of ANTXR1? 12/23/2022

Yes, alternative splicing of ANTXR1 pre-mRNA results in the generation of multiple isoforms. These isoforms may differ in their tissue-specific expression patterns and functional properties, although their precise roles are not yet fully understood.

How is ANTXR2 regulated in the cell? 11/16/2022

The regulation of ANTXR2 expression and activity is not yet fully understood. However, studies suggest that ANTXR2 expression can be modulated by various factors, including growth factors, cytokines, and extracellular matrix proteins. Additionally, post-translational modifications may also impact ANTXR2 function and localization within the cell. Further research is needed to elucidate the precise regulatory mechanisms of ANTXR2.

What diseases are associated with ANTXR1 protein? 08/29/2022

ANTXR1 mutations have been associated with susceptibility to certain types of cancer, including angiosarcoma and basal cell carcinoma.

Is ANTXR2 expression regulated by any transcription factors? 05/27/2022

There is limited information available on the transcriptional regulation of ANTXR2. One study identified the transcription factor EGR1 as a potential regulator of ANTXR2 expression in lung cancer cells. However, more research is required to determine the specific transcription factors that control ANTXR2 expression in different contexts.

Can ANTXR2 be targeted for therapeutic purposes? 11/16/2021

Targeting ANTXR2 could have potential therapeutic applications, particularly in the context of anthrax toxin. Strategies to block the interaction between ANTXR2 and PA have been explored as a means to prevent anthrax toxin entry into cells. Additionally, further investigation of ANTXR2's role in angiogenesis and tissue remodeling may offer opportunities for therapeutic intervention in related diseases.

Can ANTXR1 be targeted for therapeutic purposes? 08/23/2021

Yes, ANTXR1 has been a target for the development of anthrax antitoxins to block the binding and internalization of anthrax toxin into cells, thereby preventing the toxin's damaging effects.

What are the downstream signaling pathways activated by ANTXR2? 07/27/2021

The exact downstream signaling pathways triggered by ANTXR2 are still being explored. However, it has been suggested that ANTXR2 may activate various intracellular signaling pathways, including those involving ERK1/2, Akt, and NF-κB. These pathways are involved in cell growth, survival, and inflammation, respectively.

Are there any other proteins that interact with ANTXR2? 05/21/2021

Yes, apart from its interaction with the PA component of anthrax toxin, ANTXR2 can interact with multiple extracellular matrix proteins such as collagen and fibronectin. It can also interact with other cell surface receptors and signaling molecules involved in various cellular processes.

Are there any genetic polymorphisms or mutations in ANTXR2 associated with diseases? 04/13/2021

Yes, mutations in ANTXR2 have been identified in individuals with diseases such as hyaline fibromatosis syndrome, infantile systemic hyalinosis, and juvenile hyaline fibromatosis. These mutations disrupt the normal function of ANTXR2 and lead to the accumulation of hyaline material in various tissues.

Are there any inhibitors or drugs targeting ANTXR1? 02/08/2021

Yes, there have been efforts to develop inhibitors or antibodies that can block the interaction between ANTXR1 and anthrax toxin, thereby preventing toxin entry into cells. These inhibitors are being explored as potential therapeutics for anthrax infection.

Can ANTXR1 be used as a biomarker for certain cancers? 01/27/2021

Yes, ANTXR1 has been identified as a biomarker for several types of cancer, including angiosarcoma and basal cell carcinoma. Its overexpression in these cancers may serve as a diagnostic or prognostic marker.

Does ANTXR2 have any role in cancer? 07/17/2020

Although ANTXR2 has not been extensively studied in the context of cancer, there is evidence suggesting its involvement in tumor growth and metastasis. For example, ANTXR2 expression has been observed to be upregulated in certain types of cancer, such as colorectal cancer and ovarian cancer. Additionally, ANTXR2 has been linked to increased invasive potential and angiogenesis in cancer cells.

Does ANTXR1 have any known physiological functions unrelated to disease? 03/20/2020

Yes, ANTXR1 has physiological functions unrelated to disease. It plays a role in embryonic development, particularly in cardiovascular development and angiogenesis. ANTXR1 is also involved in tissue homeostasis, wound healing, and vasculogenesis, contributing to normal physiological processes.

How does ANTXR2 interact with anthrax toxin? 12/01/2019

ANTXR2 binds to the PA component of anthrax toxin, allowing the toxin to be internalized into cells. Along with another protein called ANTXR1, it forms a receptor complex that facilitates the entry of the lethal factor (LF) and edema factor (EF) components of the toxin into cells.

Does ANTXR1 have any known functional partners or interacting proteins? 11/16/2019

Yes, ANTXR1 has been found to interact with other proteins, such as matrix metalloproteinases (MMPs) and integrins, which are involved in extracellular matrix remodeling and cell adhesion processes.

Can ANTXR1 be targeted for therapeutic purposes? 10/13/2019

Yes, ANTXR1 has been considered a potential therapeutic target not only for anthrax infection but also for certain cancers and other diseases where its expression or function is altered. Development of specific inhibitors or targeted therapies against ANTXR1 is an area of ongoing research.

How does ANTXR1 interact with anthrax toxin? 08/10/2019

ANTXR1 binds to the protective antigen (PA) component of anthrax toxin, forming a complex that is necessary for the internalization of the toxin into susceptible cells.

Can ANTXR1 interact with other proteins? 05/05/2019

Yes, ANTXR1 can interact with numerous proteins. For example, it can bind to collagen and fibronectin, components of the extracellular matrix, facilitating cell adhesion and migration. ANTXR1 can also interact with certain intracellular signaling proteins, influencing various cellular processes.

Is ANTXR1 involved in any other diseases or conditions? 10/05/2018

ANTXR1 has been implicated in other diseases and conditions, including cardiovascular diseases, inflammation, and certain types of cancer. Its involvement in angiogenesis and cell adhesion processes makes it relevant in these pathological conditions.

Does ANTXR1 have any role in immune responses? 08/09/2018

Yes, ANTXR1 plays a role in immune responses. It has been reported to regulate the activation and function of immune cells, such as macrophages and dendritic cells. ANTXR1 is involved in the expression of pro-inflammatory cytokines and the modulation of immune cell migration and antigen presentation.

Are there any drugs or therapies targeting ANTXR1? 03/24/2018

While there are currently no approved drugs specifically targeting ANTXR1, several studies have identified potential therapeutic agents that can inhibit ANTXR1 function or expression. Some examples include small molecule inhibitors, antibodies, and RNA interference-based approaches. These strategies are being investigated for their effectiveness in preclinical models.

What are the potential therapeutic implications of targeting ANTXR2 in hyaline fibromatosis syndrome? 01/12/2018

Since ANTXR2 mutations are associated with hyaline fibromatosis syndrome, targeting ANTXR2 could be a potential therapeutic strategy. This could involve developing therapies that restore or enhance the function of ANTXR2 in affected tissues. However, more research is needed to fully understand the molecular mechanisms underlying the disease and to identify specific therapeutic targets.

How is ANTXR2 involved in angiogenesis? 07/14/2017

ANTXR2 is expressed in endothelial cells and has been shown to play a role in angiogenesis, which is the formation of new blood vessels. It is involved in promoting the ability of endothelial cells to migrate and form capillary-like structures. ANTXR2 has also been implicated in the regulation of vascular permeability.

Are there any known ligands for ANTXR2? 07/03/2017

Yes, ANTXR2 is known to interact with several extracellular matrix proteins, including collagen, laminin, and fibronectin. These interactions facilitate the internalization and degradation of these proteins. ANTXR2 has also been reported to bind to certain bacterial toxins, such as anthrax lethal factor and anthrax edema factor.

Can ANTXR2 be targeted for therapeutic purposes in diseases other than hyaline fibromatosis syndrome? 05/24/2017

The potential therapeutic targeting of ANTXR2 in diseases other than hyaline fibromatosis syndrome is still not well-established. However, given its involvement in tumor growth, metastasis, and immune responses, it is possible that ANTXR2 could be explored as a therapeutic target in cancer and other inflammatory diseases. Further research is needed to evaluate the efficacy and safety of targeting ANTXR2 in these contexts.

Is ANTXR2 involved in any physiological processes other than disease-related conditions? 03/29/2017

While the majority of research on ANTXR2 has focused on its role in diseases, there is evidence suggesting its involvement in physiological processes as well. For example, ANTXR2 has been implicated in wound healing and tissue repair, as it regulates the turnover of extracellular matrix proteins. Additionally, ANTXR2 may play a role in normal development, as evidenced by its expression in various embryonic tissues.

Are there any diseases or conditions associated with ANTXR2 mutations? 03/24/2017

Yes, mutations in the ANTXR2 gene have been found to cause a rare genetic disorder known as Hyaline fibromatosis syndrome (HFS). HFS is characterized by the accumulation of hyaline material in various tissues and can lead to a range of symptoms including joint stiffness, skin abnormalities, and organ dysfunction.

Are there any genetic disorders associated with ANTXR1 mutations? 12/30/2016

Yes, mutations in the ANTXR1 gene have been implicated in a rare genetic disorder called infantile hemangioma. This disorder is characterized by the abnormal growth of blood vessels in the skin, causing a benign tumor-like growth.

Can ANTXR1 play a role in wound healing? 09/28/2016

Yes, ANTXR1 has been shown to play a role in wound healing and tissue repair processes. It is involved in the regulation of fibroblast migration and extracellular matrix deposition, which are essential for wound closure and tissue remodeling.

Are there any other functions of ANTXR1 besides being a receptor for anthrax toxin? 09/13/2016

Yes, ANTXR1 has been found to have other roles in cellular processes such as cell adhesion, signaling pathways, and angiogenesis. It has been implicated in various physiological and pathological processes.

Is ANTXR2 involved in any other diseases or conditions? 05/31/2016

Besides Hyaline fibromatosis syndrome, ANTXR2 has been implicated in other conditions as well. Mutations in ANTXR2 have been associated with juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH), which are rare genetic disorders characterized by the abnormal accumulation of hyaline material in various tissues.

How is ANTXR1 implicated in cancer? 02/12/2016

ANTXR1 has been found to be overexpressed in various types of cancer, including breast, lung, colon, and liver cancer. Its high expression levels are associated with tumor progression, angiogenesis, and metastasis. ANTXR1 has been suggested as a potential therapeutic target for cancer treatment.

Are there any known drugs or inhibitors that target ANTXR2? 02/07/2016

Currently, there are no FDA-approved drugs specifically targeting ANTXR2. However, research is ongoing to develop therapeutic agents that can interfere with ANTXR2 function or its interaction with anthrax toxin components. Experimental agents such as monoclonal antibodies and small molecule inhibitors have been explored for their potential to target ANTXR2.

Are there any therapeutic implications of ANTXR2? 01/08/2016

The understanding of ANTXR2's role in anthrax toxin uptake has led to the development of potential therapeutic agents that target this protein. Additionally, further research on ANTXR2 may provide insights into angiogenesis-related diseases and tissue remodeling.

Customer Reviews (5)

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Reviews
12/31/2020

    the manufacturer's support has been instrumental in assisting me throughout my work with the ANTXR1 protein.

    05/24/2019

      They have not only provided insightful guidance on experimental design but also helped troubleshoot any issues I encountered during the trials.

      12/21/2017

        Its exceptional quality ensures accurate data and supports the validity of my research findings.

        06/27/2017

          Its remarkable specificity and functionality have allowed me to investigate various cellular processes with precision and confidence.

          01/11/2016

            The technical team's expertise and promptness in addressing any queries or concerns have been extraordinary.

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