ap1s1
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  • Official Full Name
  • adaptor-related protein complex 1, sigma 1 subunit
  • Background
  • The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle.
  • Synonyms
  • AP1S1; adaptor-related protein complex 1, sigma 1 subunit; CLAPS1; AP-1 complex subunit sigma-1A; AP 1 complex subunit sigma 1A; AP19; clathrin assembly protein complex 1 sigma 1A small chain; clathrin coat assembly protein AP19; clathrin associated/assembly/adaptor protein; small 1 (19kD); golgi adaptor HA1/AP1 adaptin sigma 1A subunit; HA1 19 kDa subunit; SIGMA1A; sigma1A subunit of AP 1 clathrin adaptor complex; sigma1A adaptin; WUGSC:H_DJ0747G18.2; Adapter related protein complex 1 sigma 1A subunit; Adapter-related protein complex 1 sigma-1A subunit; Adaptor protein complex AP-1 sigma-1A subunit; Adaptor protein complex AP1 sigma 1A subunit; AP1 complex subunit sigma 1A; AP1S1_HUMAN; Clathrin assembly protein complex 1 sigma-1A small chain; Golgi adaptor HA1/AP1 adaptin sigma-1A subunit; Sigma 1a subunit of AP-1 clathrin; Sigma 1a subunit of AP1 clathrin; Sigma adaptin 1A; Sigma-adaptin 1A; Sigma1A-adaptin; sigma1A subunit of AP-1 clathrin adaptor complex; clathrin-associated/assembly/adaptor protein, small 1 (19kD)
Cat.#:AP1S1-649HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AP1S1 protein, GST-tagged
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Cat.#:AP1S1-1735MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AP1S1 Protein
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Cat.#:Ap1s1-3529MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Ap1s1, His-tagged
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Cat.#:AP1S1-10638ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AP1S1
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Cat.#:AP1S1-8817HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AP1S1 293 Cell Lysate
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Involved Pathway

AP1S1 involved in several pathways and played different roles in them. We selected most pathways AP1S1 participated on our site, such as Adaptive Immune System, Clathrin derived vesicle budding, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP1S1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
CD200R4; KIF4A; BLMH; BLK; HUWE1; GRAP2A; UBA5; NRG4; SIGLEC11; RBCK1
Clathrin derived vesicle budding
TPD52; PPIAL4A; DTNBP1; TBC1D8B; CLINT1; CNO; APPB; SNX9A; PICALMB; BLOC1S4
Disease
SSRP1; GCKR; AP2B1; TTR; HDAC6; CHMP4C; HEY2; EPM2A; OPN1LW; PACS1
Golgi Associated Vesicle Biogenesis
TPD52; PPIAL4A; TPD52L1; AP4B1; YIPF6; DTNBP1B; CPD; BLOC1S6; HIP1RB; PICALM
HIV Infection
CHMP4C; DOCK2; PSTPIP2; NMT2; NPM1; RCC1; PSIP1; AP1S1; PACS1; NMT1
Host Interactions of HIV factors
DOCK2; RCC1; PPIAL4A; AP1M2; APOBEC3G; PSIP1; AP1B1; AP1S1; AP1G1; PACS1
Immune System
TXN; AGER; TRIM62; GRAP2B; TRIM50; LILRB3; IFIT2; FBXO27; GBP6; LILRA3
Infectious disease
KPNA4; AP1S1; CCDC167; AP1G1; ANTXR2; TAF1L; IPO5; LTF; PACS1; EEF2

Protein Function

AP1S1 has several biochemical functions, for example, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP1S1 itself. We selected most functions AP1S1 had, and list some proteins which have the same functions with AP1S1. You can find most of the proteins on our site.
Function
Related Protein
Function protein transporter activity
Related Protein IPO13; IPO8; L7RN6; CALCR; RANGRF; RAMP3; AP1G1; TIMM10; CALCRL; TNPO1

Interacting Protein

AP1S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP1S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP1S1.
AP1B1; Ap1g1; SLC16A1; AP1S2; RAB10; SEC61A1; IKBKE; ARMC6; EBLN2; pi3p; GTSE1

AP1S1 Related Articles

Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).