ap2b1
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  • Official Full Name
  • adaptor-related protein complex 2, beta 1 subunit
  • Background
  • Subunit of clathrin associated adaptor protein complex 1 that plays a role in protein sorting in the late Golgi/trans Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 1 (AP1) is an heterotetramer composed of two large adaptins (gamma type subunit AP1G1 and beta type subunit AP1B1), a medium adaptin (mu type subunit AP1M1 or AP1M2) and a small adaptin (sigma type subunit AP1S1 or AP1S2 or AP1S3).
  • Synonyms
  • AP2B1; adaptor-related protein complex 2, beta 1 subunit; AP-2 complex subunit beta; AP105B; beta1-adaptin; beta2-adaptin; beta-1-adaptin; beta-2-adaptin; beta-adaptin 1; AP-1 complex subunit beta-1; adaptor protein complex AP-2 subunit beta; golgi adapto
Cat.#:AP2B1-2317HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AP2B1 Protein, MYC/DDK-tagged
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Cat.#:AP2B1-652HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AP2B1 protein, GST-tagged
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Cat.#:Ap2b1-3534RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Ap2b1, His-tagged
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Cat.#:AP2B1-700RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AP2B1 Protein
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Cat.#:AP2B1-3533BTag:His
Source (Host):Mammalian CellsSpecies:Bovine
Product nameRecombinant Bovine AP2B1, His-tagged
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Cat.#:AP2B1-10288ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AP2B1
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Cat.#:AP2B1-8815HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AP2B1 293 Cell Lysate
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Involved Pathway

AP2B1 involved in several pathways and played different roles in them. We selected most pathways AP2B1 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
UBE2F; LAIR1; CTSO; KIF18A; ACTR1B; MGC174857; KLRB1F; KIF3C; CTS7; IFI30
Axon guidance
EFNA2; ARPC5; COL6A3; RGMB; UNC5C; GNAI1; NRG3; RHOD; SEMA3C; ABL1
Beta-catenin independent WNT signaling
PRICKLE1; RYK; AGO1; CLTC; PRICKLE1B; ROR2; AP2A2; AGO3; GNB5; CLTA
Developmental Biology
ADAM22; EFNA1; SCN3B; EFNA2A; RASGRP1; TCF3A; DUSP10; COL9A1; MED20; EPHB4B
Disease
AP2B1; PDCD6IP; KREMEN2; JAG1; GCKR; OPN1LW; PACS1; STX1B; NA; PSIP1
EGFR downregulation
AP2A1; SPRY2; STAM2; AP2B1; AP2A2; AP2S1; AP2M1; SPRY1; PTPRK
EPH-Ephrin signaling
MYL12B; ACTR2; EPHB4B; EFNA1A; ARPC3; KALRN; DNM1; EPHB3A; SDCBP; AP2B1
EPH-ephrin mediated repulsion of cells
AP2B1; EFNA3; EPHA2; EFNA2; EPHA4A; EFNA5; AP2S1; EFNB2; EFNA1A; EPHB3A

Protein Function

AP2B1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, clathrin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2B1 itself. We selected most functions AP2B1 had, and list some proteins which have the same functions with AP2B1. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to clathrin adaptor activity
Related Protein AP2M1; AP2S1; AP2A1; AP2B1; AP2A2
Function clathrin binding
Related Protein SYT16; TOM1; HIP1RB; SYT13; SYT3; SYTL2; AP2B1; SYT11A; SYT11; SYT2
Function protein binding
Related Protein FBXO4; UBE2I; HSP90AB1; HER11; SEPT1; SLC52A2; TCOF1; U2AF1; AIRE; FAM164C
Function protein complex binding
Related Protein AKAP5; MTHFR; MAPK8IP2; RANBP2; RPAIN; NRAS; KAT2B; CDK4; NDUFA9; THRA
Function protein transporter activity
Related Protein COX18; SEC61G; KPNA6; RAMP1; AP1G1; KPNB1; AP3S1; XPO1; TSNAX; KPNA4
Function signal sequence binding
Related Protein AP2B1; SRP68; AP2M1

Interacting Protein

AP2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2B1.
LDLRAP1; THAP1; AP1M2; Ap2m1; 10411; SLC25A6

AP2B1 Related Articles

Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).
Jones, ML; Murden, SL; et al. Disruption of AP3B1 by a chromosome 5 inversion: a new disease mechanism in Hermansky-Pudlak syndrome type 2. BMC MEDICAL GENETICS 14:-(2013).