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APBA2

  • Official Full Name

    amyloid beta (A4) precursor protein-binding, family A, member 2

  • Overview

    Amyloid beta A4 precursor protein-binding family A member 2 (APBA2) is a neuronal adaptor protein that interacts with the amyloid beta precursor protein (APP). The amyloid beta-protein (Abeta), is the principal component of amyloid plaques, a pathological
  • Synonyms

    APBA2; amyloid beta (A4) precursor protein-binding, family A, member 2; amyloid beta (A4) precursor protein binding, family A, member 2 (X11 like) , MINT2, X11 like , X11L; amyloid beta A4 precursor protein-binding family A member 2; D15S1518E; HsT16821;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APBA2-9728H Recombinant Human APBA2, GST-tagged E.coli GST 1-66a.a.
Human APBA2-8171H Recombinant Human APBA2 protein, His & T7-tagged E.coli His/T7 Tyr459~Asn722 (Accession # Q99767)
Human APBA2-667H Recombinant Human APBA2 protein, GST-tagged Wheat Germ GST
Human APBA2-8805HCL Recombinant Human APBA2 293 Cell Lysate HEK293 N/A
Human APBA2-108H Recombinant Human APBA2 protein, His&Myc-tagged E.coli His&Myc 1-749aa
Human APBA2-1078HF Recombinant Full Length Human APBA2 Protein, GST-tagged In Vitro Cell Free System GST 244 amino acids
Human APBA2-198H Recombinant Human APBA2 protein, His&Myc-tagged Mammalian cell His&Myc 1-749aa
Human APBA2-0463H Recombinant Human APBA2 Protein (Tyr459-Asn722), N-His-tagged E.coli N-His Tyr459-Asn722
Mouse APBA2-1755M Recombinant Mouse APBA2 Protein Mammalian Cell His
Mouse APBA2-613M-B Recombinant Mouse APBA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse APBA2-613M Recombinant Mouse APBA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat APBA2-708R Recombinant Rat APBA2 Protein Mammalian Cell His
Rat Apba2-3435R Recombinant Rat Apba2, His-tagged E.Coli or Yeast His 750
Rat APBA2-364R Recombinant Rat APBA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat APBA2-364R-B Recombinant Rat APBA2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APBA2 Related Articles
  • APBA2 Related Research Area

APBA2 involved in several pathways and played different roles in them. We selected most pathways APBA2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APBA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

APBA2 has several biochemical functions, for example, beta-amyloid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APBA2 itself. We selected most functions APBA2 had, and list some proteins which have the same functions with APBA2. You can find most of the proteins on our site.

Function Related Protein
beta-amyloid bindingARMCX5-GPRASP2;BACE2;TM2D1;IDE;SORL1;LDLRAP1;Apba1;LDLRAD3;BACE1
protein bindingVIPAS39;RBM10;CRYBA4;EEF1D;NCLN;CPNE6;PIM3;HOXA5;PRPS2

APBA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APBA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APBA2.

CLSTN1; USP20; App; yscK; MAPK6

Nensa, FM; Neumann, MHD; et al. Amyloid Beta A4 Precursor Protein-binding Family B Member 1 (FE65) Interactomics Revealed Synaptic Vesicle Glycoprotein 2A (SV2A) and Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 (SERCA2) as New Binding Proteins in the Human Brain. MOLECULAR & CELLULAR PROTEOMICS 13:475-488(2014).
Hao, Y; Chai, KH; et al. Promoter characterization and genomic organization of the human X11 beta gene APBA2. NEUROREPORT 23:146-151(2012).
  • Q&As
  • Reviews

Q&As (17)

Ask a question
In what diseases may recombinant APBA2 have potential medical applications? 11/12/2022

Current studies have found that the APBA2 may have a promising application in neurosystem-related diseases such as Alzheimer's disease, Parkinson's disease, and epilepsy.

What are the applications of APBA2 in drug screening? 10/26/2022

Recombinant APBA2 protein can be used in drug screening to evaluate the activity and effectiveness of various drug candidates by detecting the binding ability and affinity of different compounds to it.

What is the research significance of APBA2 ? 09/26/2022

As a protein regulating neuronal signaling, APBA2 has potential application prospects in the prevention and treatment of nervous system-related diseases, and is also of great significance for the study of the development, function and pathological mechanism of the nervous system.

How to evaluate the efficacy and safety of APBA2 ? 09/03/2022

The efficacy and safety of APBA2 can be evaluated through in vitro and in vivo pharmacological experiments, toxicity tests, clinical studies and other methods.

What is the relationship between APBA2 and synaptic plasticity? 08/15/2022

The APBA2 can promote the connection between neurons and the formation and stability of synapses, and increase the plasticity of synapses.

What is the antigenicity of APBA2 ? 03/14/2022

At present, no relevant studies have reported the specific antigenicity of APBA2 .

What is the application prospect of APBA2 in neuroethology? 10/13/2021

Recombinant APBA2 protein can be used as an indicator in neurobehavioral experiments to evaluate learning and memory ability in mice and rats.

How to realize the protective effect of APBA2 on neurons? 07/06/2021

The APBA2 can promote the formation and stability of neuronal synapses and strengthen the connections between neurons, thereby protecting neurons from damage.

How to prepare APBA2 efficiently? 03/30/2021

APBA2 protein can be expressed in cells by molecular cloning technology, and the can be purified.

What are the application prospects of recombinant APBA2 in Alzheimer's disease? 03/14/2021

APBA2 plays an important role in regulating neuronal signaling and synaptic function, so it has potential application prospects in neurosystem-related diseases such as Alzheimer's disease.

How can APBA2 be further optimized and improved? 12/30/2020

The performance of APBA2 protein in clinical and scientific applications can be further optimized and improved by changing its structure, enzymolysis site and affinity.

What is the molecular mechanism of APBA2 ? 11/27/2020

APBA2 is a key protein regulating nerve cell signal transmission, which can bind to neurotransmitter receptors, promote neurotransmitter signal transmission, increase synaptic plasticity and promote neuronal differentiation and maturation.

What is the structure of APBA2 ? 08/21/2020

The APBA2 is a protein containing multiple domains, and the three-dimensional structure of some of its structures has been analyzed, including the domain where it binds to the transmitter receptor.

In which experiments is APBA2 widely used? 05/20/2020

Recombinant APBA2 protein has been widely used in experiments of nervous system development, neurodegenerative diseases, synaptic plasticity, drug screening and so on.

How to quantify the binding capacity of APBA2 ? 01/13/2020

Binding quantitative detection of APBA2 can be performed based on in vitro hybridization, molecular crosslinking, biosensor and other technologies.

How does APBA2 bind to neurotransmitter receptors? 07/25/2019

The recombinant APBA2 protein can bind to the intrinsic domain of neurotransmitter receptors, regulating neurotransmitter signaling and synaptic plasticity.

Can APBA2 be obtained through bioengineering? 06/26/2019

Recombinant APBA2 protein can be obtained by molecular cloning technology and cell engineering technology.

Customer Reviews (4)

Write a review
Reviews
12/13/2022

    APBA2 is really amazing, and the results are very consistent every time, you can see that the production process is very careful.

    07/07/2021

      APBA2 they produced has good solubility and can dissolve easily.

      12/14/2020

        After using this recombinant protein, the quantitative accuracy of Western blot was significantly improved.

        11/18/2019

          The catalytic activity of APBA2 is excellent, and it can make tedious chemical reactions simple, and its simplification is to be appreciated.

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