apbb1
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  • Official Full Name
  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
  • Background
  • The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the;nucleus. It interacts with the Alzheimers disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1;and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent;the gene products nuclear translocation. This encoded protein could play an important role in the pathogenesis of;Alzheimers disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by;downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different;isoforms have been described for this gene.
  • Synonyms
  • APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); RIR; amyloid beta A4 precursor protein-binding family B member 1; Fe65; stat-like protein; adaptor protein FE65a2; MGC:9072
Cat.#:APBB1-1655HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APBB1 protein, His & T7-tagged
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Cat.#:APBB1-668HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APBB1 protein, GST-tagged
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Cat.#:APBB1-1757MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse APBB1 Protein
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Cat.#:Apbb1-3437RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Apbb1, His-tagged
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Cat.#:APBB1-710RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat APBB1 Protein
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Cat.#:APBB1-8803HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human APBB1 293 Cell Lysate
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Cat.#:APBB1-8804HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human APBB1 293 Cell Lysate
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Involved Pathway

APBB1 involved in several pathways and played different roles in them. We selected most pathways APBB1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APBB1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alzheimers disease
FAS; NDUFA9; GRIN2C; COX4I1; COX7C; CASP7; NAE1; APH1B; GRIN2A; NDUFS5

Protein Function

APBB1 has several biochemical functions, for example, beta-amyloid binding, chromatin binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APBB1 itself. We selected most functions APBB1 had, and list some proteins which have the same functions with APBB1. You can find most of the proteins on our site.
Function
Related Protein
Function beta-amyloid binding
Related Protein APBA3; OLFM1; APOE; APBB3; APBB1; LDLRAD3; BACE1; TM2D1; BACE2; ITM2C
Function chromatin binding
Related Protein SALL1; KLF6A; PSIP1; MSL1A; RBPJ; HMGA1; HCFC1; MEIS3; TAF2; ZFP143
Function histone binding
Related Protein SUPT6H; HIST1H3C; JAK2; SIRT1; PRKCB; HIST1H4D; H3F3A; PHF21A; RNF168; USP49
Function proline-rich region binding
Related Protein GHR; NEDD4; YAP1; TCERG1; ABI2; ABL1; APBB1; FAM59A; CCND1; WBP4
Function protein binding
Related Protein HEMK1; PSMD2; KIRREL; VIPR1; YIPF4; IL1RN; ASCL3; KCNJ10; RAF1; CFH
Function transcription factor binding
Related Protein HEY1; RNF222; CAMTA2; KEAP1B; KAT6B; JUN; MED1; E2F4; NKX2-5; PBX2

Interacting Protein

APBB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APBB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APBB1.
APP; LRP1; APP; EGFR; ERBB2; CLSTN1; ANXA1; App; ATXN1