Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

APC2

  • Official Full Name

    adenomatosis polyposis coli 2

  • Overview

    APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor.
  • Synonyms

    APC2; adenomatosis polyposis coli 2; APCL; adenomatous polyposis coli protein 2; adenomatous polyposis coli like;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APC2-3154H Recombinant Human APC2, His-tagged E.Coli or Yeast His 2303
Chicken APC2-4062C Recombinant Chicken APC2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

APC2 involved in several pathways and played different roles in them. We selected most pathways APC2 participated on our site, such as Basal cell carcinoma, Colorectal cancer, Endometrial cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with APC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Basal cell carcinomaPTCH2;DVL1;GSK3B;APC;FZD7;WNT11;WNT3;GLI1;WNT5A
Colorectal cancerMAPK3;AXIN2;KRAS;AXIN1;TGFB1;PIK3CG;BRAF;SMAD3;APC
Endometrial cancerNRAS;ARAF;AXIN1;PIK3R1;SOS1;BAD;ELK1;BRAF;PTEN
HTLV-I infectionH2-AA;TBP;TLN1;WNT11;CREM;HLA-DOA;WNT5A;WNT7B;PPP3R2
Hippo signaling pathwayWNT4;RASSF1;DLG1;AREG;WTIP;YWHAZ;WWC1;TP73;TEAD1
MicroRNAs in cancerCYP24A1;TGFB2;BMPR2;PLAU;CDC25B;BCL2L2;TPM1;TP53;MAP2K2
Pathways in cancerMDM2;TGFBR2;NFKB1;MAP2K1;FLT3LG;SMAD4;RXRG;EGLN3;FOXO1
Regulation of actin cytoskeletonACTN1;SLC9A1;MYH9;DIAP3;ARPC5L;PDGFD;MYLPFA;FGF20B;PDGFC

APC2 has several biochemical functions, for example, beta-catenin binding, gamma-catenin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APC2 itself. We selected most functions APC2 had, and list some proteins which have the same functions with APC2. You can find most of the proteins on our site.

Function Related Protein
beta-catenin bindingESR1;VCL;PTPRJ;CXADR;KLF4;SLC9A3R2;DACT1;CTNNA1;GRIP1
gamma-catenin bindingLEF1;DSG1;CDH1;APC;PTBP3;CDH2;PTPRK;CTNNA1;PTPRJ
microtubule bindingNPSNL;ARHGEF2;CEP57L1;FGF13;VAPB;PAFAH1B1A;SPAG8;TRPV4;KIF12
protein bindingWAC;KPNA3;ARHGAP4;APOBEC3H;MRPS6;VAPA;STXBP4;ITPRIPL1;NONO

APC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APC2.

MAPRE3; TP53BP2; MAPRE1; TIMP2; YBX1

  • Q&As
  • Reviews

Q&As (20)

Ask a question
What is the effect of APC2 on tumor cell proliferation and metastasis? 09/10/2022

APC2 is considered to be a tumor suppressor gene, and its deletion or mutation may lead to enhanced proliferation and metastasis of tumor cells.

What are the structural characteristics of APC2? 06/11/2022

The structural characteristics of APC2 include multiple functional domains, involvement in signal transduction inside and outside the cell, and interaction with a variety of proteins.

Is there a polymorphic mutation in APC2? 01/20/2022

Polymorphic mutations exist in APC2, and the type and location of mutations may vary between individuals.

Is APC2 relevant to tumor immunotherapy? 01/19/2022

At present, no relevant studies have shown that APC2 has a direct relationship with tumor immunotherapy.

Can APC2 be used as a tumor marker? 01/18/2022

The presence of mutations in APC2 may lead to tumor cell proliferation, but whether it is used as a marker for specific tumors needs further study.

What is the role of APC2 in apoptosis? 11/24/2021

APC2 is antitumor by promoting apoptosis.

What is the effect of APC2 on tumor stem cells? 09/14/2021

APC2 may play a role in tumor inhibition by inhibiting the proliferation and differentiation of tumor stem cells.

What role does APC2 play in the development of tumor? 07/27/2021

APC2 plays a complex regulatory role in tumorigenesis and development, including the regulation of signaling pathways such as Wnt, the influence of cell proliferation and apoptosis, and the regulation of cell cycle. The exact mechanism still needs further study.

What is the relationship between APC2 and tumor prognosis? 05/20/2021

Deletion or mutation of APC2 may lead to enhanced proliferation and metastasis of tumor cells, which may adversely affect tumor prognosis.

What is the recent research progress of APC2? 12/23/2020

Recent studies have shown that APC2 also plays an important role in aspects such as cell polarity and angiogenesis, and related studies are ongoing.

How does the mutation rate of APC2 differ among different cancers? 12/21/2020

The mutation rate of APC2 varies widely among different cancers, such as colon and stomach cancer.

How does APC2 interact with other cytokines? 08/24/2020

APC2 can interact with receptors, signal transduction factors and other cytokines, including Wnt, β-catenin, TGF-β and so on.

How is APC2 applied in clinical diagnosis? 06/25/2020

APC2 has not yet been used in clinical diagnosis, but with further research, more applications may be possible.

Is APC2 associated with neurodegenerative diseases? 03/04/2020

Some studies have suggested that APC2 may be involved in neurodegenerative diseases such as Alzheimer's and Parkinson's, but the specific mechanism needs further study.

How can APC2 be used in drug design? 01/25/2020

The study of APC2 can provide references for drug design, such as finding new tumor therapeutic targets and designing new tumor drugs.

What are the expression and purification methods of the full-length of APC2? 01/17/2020

The expression and purification methods of the full-length of APC2 include prokaryotic and eukaryotic expression.

Are mutations in the subunits of APC2 substrates associated with certain cancers? 12/31/2019

Studies have shown that in patients with colon and stomach cancer, there is a higher probability of mutations in the subunit of APC2 substrate binding.

What is the relationship between APC2 and tumor pharmacology? 09/23/2019

The study of APC2 is of great significance for the development of tumor pharmacology and can provide reference for finding new anticancer therapeutic targets.

What is the relationship between the structure and function of APC2? 04/28/2019

There is a close relationship between the structure and function of APC2, and its different domains and functional areas can be involved in different cellular signal transduction and regulation processes.

What is the pro-apoptotic mechanism of APC2 on tumor cells? 02/20/2019

APC2 can play a role in promoting apoptosis by activating the apoptosis pathway in tumor cells, such as activating caspase.

Customer Reviews (5)

Write a review
Reviews
07/02/2022

    APC2 production process is truly green, environmentally friendly, and has almost no impact on the environment, demonstrating the concept of sustainable development.

    04/25/2021

      The stability of APC2 is very excellent, and its performance remains stable even after a long period of storage or multiple freeze-thaw cycles, which shows its excellent storage stability.

      08/29/2020

        Catalytic activity of APC2 is very powerful, and it can successfully complete difficult chemical reactions, and its breakthrough effect is admirable.

        01/25/2019

          Short half-life and high clearance characteristics of APC2 provide patients with more timely and effective treatment.

          01/17/2019

            The stability of APC2 is truly amazing, and the performance remains the same even after multiple uses, showing excellent product quality.

            Ask a Question for All APC2 Products

            Required fields are marked with *

            My Review for All APC2 Products

            Required fields are marked with *

            logo

            FOLLOW US

            Terms and Conditions        Privacy Policy

            Copyright © 2024 Creative BioMart. All Rights Reserved.

            Contact Us

            • /

            Stay Updated on the Latest Bioscience Trends