APC2
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Official Full Name
adenomatosis polyposis coli 2
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Overview
APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor. -
Synonyms
APC2; adenomatosis polyposis coli 2; APCL; adenomatous polyposis coli protein 2; adenomatous polyposis coli like;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | APC2-3154H | Recombinant Human APC2, His-tagged | E.Coli or Yeast | His | 2303 | |
Chicken | APC2-4062C | Recombinant Chicken APC2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
APC2 involved in several pathways and played different roles in them. We selected most pathways APC2 participated on our site, such as Basal cell carcinoma, Colorectal cancer, Endometrial cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with APC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Basal cell carcinoma | PTCH2;DVL1;GSK3B;APC;FZD7;WNT11;WNT3;GLI1;WNT5A |
Colorectal cancer | MAPK3;AXIN2;KRAS;AXIN1;TGFB1;PIK3CG;BRAF;SMAD3;APC |
Endometrial cancer | NRAS;ARAF;AXIN1;PIK3R1;SOS1;BAD;ELK1;BRAF;PTEN |
HTLV-I infection | H2-AA;TBP;TLN1;WNT11;CREM;HLA-DOA;WNT5A;WNT7B;PPP3R2 |
Hippo signaling pathway | WNT4;RASSF1;DLG1;AREG;WTIP;YWHAZ;WWC1;TP73;TEAD1 |
MicroRNAs in cancer | CYP24A1;TGFB2;BMPR2;PLAU;CDC25B;BCL2L2;TPM1;TP53;MAP2K2 |
Pathways in cancer | MDM2;TGFBR2;NFKB1;MAP2K1;FLT3LG;SMAD4;RXRG;EGLN3;FOXO1 |
Regulation of actin cytoskeleton | ACTN1;SLC9A1;MYH9;DIAP3;ARPC5L;PDGFD;MYLPFA;FGF20B;PDGFC |
APC2 has several biochemical functions, for example, beta-catenin binding, gamma-catenin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APC2 itself. We selected most functions APC2 had, and list some proteins which have the same functions with APC2. You can find most of the proteins on our site.
Function | Related Protein |
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beta-catenin binding | ESR1;VCL;PTPRJ;CXADR;KLF4;SLC9A3R2;DACT1;CTNNA1;GRIP1 |
gamma-catenin binding | LEF1;DSG1;CDH1;APC;PTBP3;CDH2;PTPRK;CTNNA1;PTPRJ |
microtubule binding | NPSNL;ARHGEF2;CEP57L1;FGF13;VAPB;PAFAH1B1A;SPAG8;TRPV4;KIF12 |
protein binding | WAC;KPNA3;ARHGAP4;APOBEC3H;MRPS6;VAPA;STXBP4;ITPRIPL1;NONO |
APC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APC2.
MAPRE3; TP53BP2; MAPRE1; TIMP2; YBX1
- Q&As
- Reviews
Q&As (20)
Ask a questionAPC2 is considered to be a tumor suppressor gene, and its deletion or mutation may lead to enhanced proliferation and metastasis of tumor cells.
The structural characteristics of APC2 include multiple functional domains, involvement in signal transduction inside and outside the cell, and interaction with a variety of proteins.
Polymorphic mutations exist in APC2, and the type and location of mutations may vary between individuals.
At present, no relevant studies have shown that APC2 has a direct relationship with tumor immunotherapy.
The presence of mutations in APC2 may lead to tumor cell proliferation, but whether it is used as a marker for specific tumors needs further study.
APC2 is antitumor by promoting apoptosis.
APC2 may play a role in tumor inhibition by inhibiting the proliferation and differentiation of tumor stem cells.
APC2 plays a complex regulatory role in tumorigenesis and development, including the regulation of signaling pathways such as Wnt, the influence of cell proliferation and apoptosis, and the regulation of cell cycle. The exact mechanism still needs further study.
Deletion or mutation of APC2 may lead to enhanced proliferation and metastasis of tumor cells, which may adversely affect tumor prognosis.
Recent studies have shown that APC2 also plays an important role in aspects such as cell polarity and angiogenesis, and related studies are ongoing.
The mutation rate of APC2 varies widely among different cancers, such as colon and stomach cancer.
APC2 can interact with receptors, signal transduction factors and other cytokines, including Wnt, β-catenin, TGF-β and so on.
APC2 has not yet been used in clinical diagnosis, but with further research, more applications may be possible.
Some studies have suggested that APC2 may be involved in neurodegenerative diseases such as Alzheimer's and Parkinson's, but the specific mechanism needs further study.
The study of APC2 can provide references for drug design, such as finding new tumor therapeutic targets and designing new tumor drugs.
The expression and purification methods of the full-length of APC2 include prokaryotic and eukaryotic expression.
Studies have shown that in patients with colon and stomach cancer, there is a higher probability of mutations in the subunit of APC2 substrate binding.
The study of APC2 is of great significance for the development of tumor pharmacology and can provide reference for finding new anticancer therapeutic targets.
There is a close relationship between the structure and function of APC2, and its different domains and functional areas can be involved in different cellular signal transduction and regulation processes.
APC2 can play a role in promoting apoptosis by activating the apoptosis pathway in tumor cells, such as activating caspase.
Customer Reviews (5)
Write a reviewAPC2 production process is truly green, environmentally friendly, and has almost no impact on the environment, demonstrating the concept of sustainable development.
The stability of APC2 is very excellent, and its performance remains stable even after a long period of storage or multiple freeze-thaw cycles, which shows its excellent storage stability.
Catalytic activity of APC2 is very powerful, and it can successfully complete difficult chemical reactions, and its breakthrough effect is admirable.
Short half-life and high clearance characteristics of APC2 provide patients with more timely and effective treatment.
The stability of APC2 is truly amazing, and the performance remains the same even after multiple uses, showing excellent product quality.
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