APCDD1
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Official Full Name
adenomatosis polyposis coli down-regulated 1
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Overview
This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis. -
Synonyms
APCDD1; adenomatosis polyposis coli down-regulated 1; protein APCDD1; B7323; Adenomatosis polyposis coli down regulated 1; Adenomatosis polyposis coli down regulated 1 protein; APCDD 1; DRAPC1; FP7019; adenomatosis polyposis coli down-regulated 1 protein; HHS; HTS;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Fc
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | APCDD1-672H | Recombinant Human APCDD1 protein, GST-tagged | Wheat Germ | GST | ||
Human | APCDD1-9733H | Recombinant Human APCDD1, His-tagged | E.coli | His | 141-496a.a. | |
Human | APCDD1-223H | Recombinant Human APCDD1, Fc-tagged | Human Cell | Fc | Met1-Gly486 | |
Human | APCDD1-001HCL | Recombinant Human APCDD1 cell lysate | Human Cell | N/A | ||
Human | APCDD1-4325H | Recombinant Human APCDD1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | APCDD1-2313H | Recombinant Human APCDD1 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | APCDD1-1383HF | Recombinant Full Length Human APCDD1 Protein, GST-tagged | In Vitro Cell Free System | GST | 514 amino acids | |
Mouse | APCDD1-1763M | Recombinant Mouse APCDD1 Protein | Mammalian Cell | His | ||
Mouse | APCDD1-616M | Recombinant Mouse APCDD1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | APCDD1-616M-B | Recombinant Mouse APCDD1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Apcdd1-1657M | Recombinant Mouse Apcdd1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Chicken | APCDD1-2153C | Recombinant Chicken APCDD1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
APCDD1 involved in several pathways and played different roles in them. We selected most pathways APCDD1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APCDD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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APCDD1 has several biochemical functions, for example, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APCDD1 itself. We selected most functions APCDD1 had, and list some proteins which have the same functions with APCDD1. You can find most of the proteins on our site.
Function | Related Protein |
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Wnt-protein binding | SFRP2;LRP6;FZD8A;FZD5;ROR2;FZD3;SETD6;GPR177;FZD7A |
APCDD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APCDD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APCDD1.
RXRB
- Q&As
- Reviews
Q&As (20)
Ask a questionAPCDD1 protein has not been shown to have a direct relationship with pneumonia-tuberculosis.
No clear relationship between APCDD1 protein and immune response has been found.
Studies have shown that the expression level of APCDD1 gene in liver cancer tissues is significantly decreased, and its deletion may be closely related to the occurrence and development of liver cancer.
The role of APCDD1 protein in hepatitis is not yet clear, but it may be related to hepatocyte dysfunction and apoptosis.
The APCDD1 protein is a member of the Wnt inhibitor family and mainly consists of an N-terminal signaling peptide and a C-terminal maturation peptide. The C-terminal peptide chain is mainly composed of multiple interlaced cysteine residues, forming a special domain.
The mechanism of action of APCDD1 protein is independent of the RNA splicing process.
APCDD1 protein may be involved in cardiomyocyte apoptosis, vascular endothelial cell proliferation and other processes in cardiovascular diseases.
The mechanism of action of APCDD1 protein makes it a potential targeted therapeutic molecule, but the relevant clinical studies are currently lacking.
The polymorphism of APCDD1 protein may affect its structure and function, but the exact extent of the impact needs more research.
The APCDD1 protein has not been shown to have a clear relationship with calcium ion regulation in the body.
The APCDD1 protein is a product of the Apcdd1 gene, and the mRNA encoding the protein is translated by the ribosome to produce the immature protein. The immature APCDD1 protein is processed through a ubiquitin-dependent degradation pathway to form the final mature protein.
The degradation pathway of APCDD1 protein mainly involves ubiquitination reactions catalyzed by protein ubiquitination enzymes.
APCDD1 protein is mainly associated with epithelial cells and mesenchymal cells.
APCDD1 protein expression pattern is tissue-specific, mainly expressed in gastrointestinal tract, breast, lung, liver and heart tissues.
The inhibitory effect of APCDD1 protein may provide certain reference significance for the treatment of other diseases, such as neuroblastoma.
APCDD1 protein can inhibit the activity of Wnt signaling pathway, thereby affecting cell proliferation, differentiation and apoptosis. Its mechanism is mainly through binding to the Wnt protein, making it inactive, thereby preventing the transmission of Wnt signals.
APCDD1 protein is associated with a variety of tumors, such as colon, breast, and esophageal cancer. In addition, APCDD1 protein is also associated with congenital heart disease, diabetes and other diseases.
APCDD1 protein has not yet been found to be useful in clinical diagnosis, but it may be a therapeutic target for some diseases.
APCDD1 protein may be associated with nutrient metabolism, but the specific mechanism remains to be further studied.
APCDD1 protein may be involved in tumor cell apoptosis and cell cycle control in tumor therapy, but the specific mechanism of action needs more research.
Customer Reviews (4)
Write a reviewRepeatability of APCDD1 is unmatched, and the results are very consistent in each experiment or application, making it ideal for experiments or applications that require a high degree of repeatability.
The reproducibility of APCDD1 is very good, which can ensure the reliability of the experimental results and facilitate the subsequent research and application.
APCDD1 produced by them has long activity retention time and good experimental effect.
After using APCDD1, the experimental time of Western blot was significantly shortened.
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