APH1A
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Official Full Name
anterior pharynx defective 1 homolog A
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Overview
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimers disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. -
Synonyms
APH1A; anterior pharynx defective 1 homolog A (C. elegans); gamma-secretase subunit APH-1A; APH 1A; CGI 78; aph-1alpha; presenilin-stabilization factor; APH-1; APH-1A; CGI-78; 6530402N02Rik;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | APH1A-2712H | Recombinant Human APH1A Full Length Transmembrane protein (1-247 aa), His-SUMO-tagged | In vitro E. coli expression system | His-SUMO | 1-247aa |
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| Mus musculus (Mouse) | RFL14744MF | Recombinant Full Length Mouse Gamma-Secretase Subunit Aph-1A(Aph1A) Protein, His-Tagged | E.coli expression system | His | Full Length (1-265) |
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| Rhesus Macaque | APH1A-355R | Recombinant Rhesus monkey APH1A Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | APH1A-184R-B | Recombinant Rhesus Macaque APH1A Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | APH1A-184R | Recombinant Rhesus Macaque APH1A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- APH1A Related Research Area
- APH1A Related Signal Pathway
APH1A involved in several pathways and played different roles in them. We selected most pathways APH1A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APH1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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APH1A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by APH1A itself. We selected most functions APH1A had, and list some proteins which have the same functions with APH1A. You can find most of the proteins on our site.
| Function | Related Protein |
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APH1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APH1A here. Most of them are supplied by our site. Hope this information will be useful for your research of APH1A.
- Q&As
- Reviews
Q&As (20)
Ask a questionAPH1A is related to Alzheimer's disease and other diseases, and has certain research and application prospects for the treatment of related diseases.
APH1A s are involved in the formation of gamma secretase complexes that regulate cell signaling pathways.
APH1A s interact with other gamma-secretase complex members, such as PS1 and Nct, to jointly regulate signaling in cells.
APH1A s, together with the gamma secretase complex, are involved in the production and metabolism of amyloid beta.
At present, the structural analysis of APH1A is relatively limited, but future studies may have important breakthroughs.
APH1A s are involved in the assembly of the gamma secretase complex, interacting with other members such as PS1 and Nct to achieve complex formation.
Studying the APH1A could help to understand how dysfunction of the gamma secretase complex contributes to the development of Alzheimer's disease.
The dysfunction of APH1A and γ-secretase complex is closely related to Alzheimer's disease.
The APH1A is a single membrane protein with a transmembrane structure.
The feasibility of functional loss repair depends on the specific degree and mechanism of loss, and the research is still in progress.
Yes, low APH1A expression is associated with some neurodegenerative diseases such as Alzheimer's disease.
APH1A can be synthesized by genetic engineering and purified by mass spectrometry, column chromatography and other techniques.
Antibodies to APH1A can be used to detect APH1A expression levels, which is helpful in the diagnosis of some neurodegenerative diseases.
APH1A participates in the function of γ-secreting enzyme complex, regulates the metabolism of amyloid beta, and is associated with memory function to some extent.
There are several subtypes of APH1A s, including APH1A-1 and APH1A-2.
APH1A s can be used to treat diseases associated with gamma secretase complexes, such as Alzheimer's disease.
Knockout models of APH1A s can be used to validate the role of APH1A in physiological and pathological processes and deepen our understanding of its function.
Yes, mutations in the APH1A may lead to dysfunction of the gamma secretase complex, leading to the development of related diseases.
APH1A plays an important role in regulating protein complex assembly and signaling in nervous system development.
Side effects of APH1A s include possible adverse reactions during treatment and other physiological changes associated with the gamma-secretase complex.
Customer Reviews (3)
Write a reviewAPH1A they produced were structurally stable and not prone to mutation.
The production process of APH1A is truly green and environmentally friendly, without any negative impact on the environment, and meets the requirements of environmental protection regulations.
This advantage of short half-life and high clearance allows APH1A to still act quickly in medical emergencies.
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